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Kum Kum Khanna

Kum Kum Khanna

D-Index & Metrics

Molecular Biology

D-Index
91
Citations
28941
World Ranking
722
National Ranking
19

Overview

Kum Kum Khanna is affiliated with the QIMR Berghofer Medical Research Institute in Australia. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with specific concentration in Medicine. Within these domains, they have contributed extensively to subfields such as Molecular Biology, Oncology, Cell Biology, Cancer Research, and Pulmonary and Respiratory Medicine.

Themes central to their work include DNA Repair Mechanisms, Microtubule and mitosis dynamics, RNA Research and Splicing, PARP inhibition in cancer therapy, Cancer Genomics and Diagnostics, Epigenetics and DNA Methylation, and RNA modifications and cancer.

Among their recent publications are the following papers:

  • CX-5461 activates the DNA damage response and demonstrates therapeutic efficacy in high-grade serous ovarian cancer, 2020, Nature Communications
  • Chromosome arm aneuploidies shape tumour evolution and drug response, 2020, Nature Communications
  • RNA-binding protein NONO contributes to cancer cell growth and confers drug resistance as a theranostic target in TNBC, 2020, Theranostics
  • Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition, 2020, Theranostics
  • Cep55 overexpression promotes genomic instability and tumorigenesis in mice, 2020, Communications Biology

The frequent coauthors who have collaborated with Kum Kum Khanna include Murugan Kalimutho, Pascal H. G. Duijf, Prahlad V. Raninga, Behnam Rashidieh, and Amanda L. Bain.

Their work has appeared in several publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Trends in Pharmacological Sciences
  • Nature Communications
  • Theranostics
  • Communications Biology

Best Publications

  • DNA double-strand breaks: signaling, repair and the cancer connection.

    Kum Kum Khanna;Stephen P. Jackson

  • From selenium to selenoproteins: Synthesis, identity, and their role in human health

    Laura Vanda Papp;Jun Lu;Arne Holmgren;Kum Kum Khanna

  • Whole-genome landscape of pancreatic neuroendocrine tumours

    Aldo Scarpa;David K. Chang;Katia Nones;Katia Nones;Vincenzo Corbo

  • Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A

    Claus Storgaard Sørensen;Randi G. Syljuåsen;Jacob Falck;Tine Schroeder

  • ATM associates with and phosphorylates p53: mapping the region of interaction

    Kum Kum Khanna.;Katherine E. Keating;Sergei Kozlov;Shaun Scott

  • A Comprehensive Review on Current Advances in Peptide Drug Development and Design.

    Andy Chi-Lung Lee;Janelle Louise Harris;Kum Kum Khanna;Ji-Hong Hong

  • ATM-dependent phosphorylation of nibrin in response to radiation exposure

    Magtouf Gatei;David Young;Karen M. Cerosaletti;Ami Desai-Mehta

  • Interaction between ATM protein and c-Abl in response to DNA damage

    T Shafman;K K Khanna;P Kedar;K Spring

  • DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

    Q Song;S P Lees-Miller;S Kumar;Z Zhang

  • Dominant Negative ATM Mutations in Breast Cancer Families

    Georgia Chenevix-Trench;Amanda B. Spurdle;Magtouf Gatei;Helena Kelly

  • Ataxia-telangiectasia-mutated (ATM) and NBS1-dependent phosphorylation of Chk1 on Ser-317 in response to ionizing radiation.

    Magtouf Gatei;Katie Sloper;Claus Sörensen;Randi Syljuäsen

  • Cdk1/Erk2- and Plk1-dependent phosphorylation of a centrosome protein, Cep55, is required for its recruitment to midbody and cytokinesis

    Megan Fabbro;Bin-Bing Zhou;Mikiko Takahashi;Boris Sarcevic

  • Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity *

    Bin-Bing S. Zhou;Priya Chaturvedi;Kevin Spring;Shaun P. Scott

  • Role for ATM in DNA damage-induced phosphorylation of BRCA1.

    Magtouf Gatei;Shaun P. Scott;Igor Filippovitch;Natasha Soronika

  • Ionizing radiation and UV induction of p53 protein by different pathways in ataxia-telangiectasia cells.

    Kum Kum Khanna;M. F. Lavin

  • ATM, a central controller of cellular responses to DNA damage

    KK Khanna;MF Lavin;SP Jackson;TD Mulhern

  • Autophosphorylation of ataxia-telangiectasia mutated is regulated by protein phosphatase 2A

    Aaron A Goodarzi;Jyoti C Jonnalagadda;Pauline Douglas;David Young

  • Mutations in the selenocysteine insertion sequence–binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

    Erik Schoenmakers;Maura Agostini;Catherine Mitchell;Nadia Schoenmakers

  • A Cytoplasmic ATM-TRAF6-cIAP1 Module Links Nuclear DNA Damage Signaling to Ubiquitin-Mediated NF-κB Activation

    Michael Hinz;Michael Stilmann;Seda Çöl Arslan;Seda Çöl Arslan;Kum Kum Khanna

  • ATM associates with and phosphorylates p53 Mapping the region of interaction

    K. K. m Khanna;K. E. Keating;S. Kozlov;S. P. Lees Miller

Frequent Co-Authors

Martin F. Lavin
Martin F. Lavin University of Queensland
Sunil R. Lakhani
Sunil R. Lakhani University of Queensland
Georgia Chenevix-Trench
Georgia Chenevix-Trench QIMR Berghofer Medical Research Institute
Tej K. Pandita
Tej K. Pandita Houston Methodist
Nicola Waddell
Nicola Waddell QIMR Berghofer Medical Research Institute
Mark A. Ragan
Mark A. Ragan University of Queensland
Amanda B. Spurdle
Amanda B. Spurdle QIMR Berghofer Medical Research Institute
Raj K. Pandita
Raj K. Pandita Houston Methodist
Sean M. Grimmond
Sean M. Grimmond University of Melbourne
Clare L. Scott
Clare L. Scott Walter and Eliza Hall Institute of Medical Research

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