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Molecular Biology

D-Index
71
Citations
23228
World Ranking
1356
National Ranking
687

Overview

Tanya T. Paull is affiliated with The University of Texas at Austin in the United States. Their research spans multiple fields, primarily focusing on Biochemistry, Genetics and Molecular Biology, with additional work in Medicine. Within these areas, their contributions concentrate on Molecular Biology, Oncology, Cellular and Molecular Neuroscience, Cancer Research, and Cell Biology.

The scientist's work covers several main research topics, including DNA Repair Mechanisms, CRISPR and Genetic Engineering, PARP inhibition in cancer therapy, Genomics and Chromatin Dynamics, Mitochondrial Function and Pathology, Genetic Neurodegenerative Diseases, and Epigenetics and DNA Methylation.

Frequent publication venues for Tanya T. Paull include bioRxiv (Cold Spring Harbor Laboratory), where they have published five papers, followed by Cell Reports with four publications. Their research also appears in Nature Communications, DNA Repair, and Methods in Molecular Biology.

Selected recent papers by Tanya T. Paull are:

  • Cellular functions of the protein kinase ATM and their relevance to human disease, 2021, Nature Reviews Molecular Cell Biology
  • DNA-dependent protein kinase promotes DNA end processing by MRN and CtIP, 2020, Science Advances
  • ATM and PRDM9 regulate SPO11-bound recombination intermediates during meiosis, 2020, Nature Communications
  • Mitochondria at the crossroads of ATM-mediated stress signaling and regulation of reactive oxygen species, 2020, Redox Biology
  • Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells, 2020, PLoS Biology

Tanya T. Paull collaborates frequently with a core group of co-authors, including Ji-Hoon Lee and Rajashree A. Deshpande, both contributing to numerous works alongside Paull. Other notable co-authors are Nicolette A. Ender, Phillip R. Woolley, and Seung Woo Ryu.

Best Publications

  • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage.

    Tanya T Paull;Emmy P Rogakou;Vikky Yamazaki;Cordula U Kirchgessner

  • ATM Activation by DNA Double-Strand Breaks Through the Mre11-Rad50-Nbs1 Complex

    Ji-Hoon Lee;Tanya T. Paull

  • The 3′ to 5′ Exonuclease Activity of Mre11 Facilitates Repair of DNA Double-Strand Breaks

    Tanya T. Paull;Martin Gellert

  • ATM Activation by Oxidative Stress

    Zhi Guo;Sergei Kozlov;Martin F. Lavin;Maria D. Person

  • Direct Activation of the ATM Protein Kinase by the Mre11/Rad50/Nbs1 Complex

    Ji-Hoon Lee;Tanya T. Paull

  • MDC1 Maintains Genomic Stability by Participating in the Amplification of ATM-Dependent DNA Damage Signals

    Zhenkun Lou;Katherine Minter-Dykhouse;Sonia Franco;Monica Gostissa

  • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex

    Tanya T. Paull;Martin Gellert

  • Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

    J. H. Lee;Tanya T Paull

  • Mechanisms of ATM Activation

    Tanya T Paull

  • A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex

    Aude Dupré;Louise Boyer-Chatenet;Louise Boyer-Chatenet;Rose M Sattler;Ami P Modi

  • ATM functions at the peroxisome to induce pexophagy in response to ROS

    Jiangwei Zhang;Durga Nand Tripathi;Ji Jing;Angela Alexander

  • The nonspecific DNA-binding and -bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures.

    Tanya T. Paull;Michael J. Haykinson;Reid C. Johnson

  • The ATM protein kinase and cellular redox signaling: Beyond the DNA damage response

    Scott Ditch;Tanya T. Paull

  • Direct DNA binding by Brca1

    Tanya T. Paull;David Cortez;Blair Bowers;Stephen J. Elledge

  • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex

    Bettina M. Lengsfeld;Alison J. Rattray;Venugopal Bhaskara;Rodolfo Ghirlando

  • Stimulation of V(D)J cleavage by high mobility group proteins

    Dik C. van Gent;Kevin Hiom;Tanya T. Paull;Martin Gellert

  • Involvement of human MOF in ATM function

    Arun Gupta;Girdhar G. Sharma;Charles S H Young;Manjula Agarwal

  • Single-stranded DNA-binding protein hSSB1 is critical for genomic stability

    Derek J. Richard;Emma Bolderson;Liza Cubeddu;Liza Cubeddu;Ross I. M. Wadsworth

  • Mre11–Rad50–Xrs2 and Sae2 promote 5′ strand resection of DNA double-strand breaks

    Matthew L Nicolette;Kihoon Lee;Zhi Guo;Mridula Rani

  • Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

    Eun Yong Shim;Woo Hyun Chung;Matthew L. Nicolette;Yu Zhang

Frequent Co-Authors

Martin Gellert
Martin Gellert National Institute of Diabetes and Digestive and Kidney Diseases
Shunichi Takeda
Shunichi Takeda Shenzhen University
André Nussenzweig
André Nussenzweig National Institutes of Health
Jean Gautier
Jean Gautier Columbia University
John A. Tainer
John A. Tainer The University of Texas MD Anderson Cancer Center
Tej K. Pandita
Tej K. Pandita Houston Methodist
Kum Kum Khanna
Kum Kum Khanna Mater Research
Martin F. Lavin
Martin F. Lavin University of Queensland
Richard Baer
Richard Baer Columbia University
Markus Löbrich
Markus Löbrich Technical University of Darmstadt

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