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Molecular Biology

D-Index
64
Citations
21337
World Ranking
1710
National Ranking
119

Overview

Markus Löbrich is affiliated with the Technical University of Darmstadt in Germany. Their research primarily focuses on fields related to Biochemistry, Genetics, and Molecular Biology, with additional contributions in Medicine. Their specialized subfields include Molecular Biology, Oncology, Cancer Research, Radiology, Nuclear Medicine and Imaging, and Pediatrics, Perinatology and Child Health.

Löbrich's scientific work encompasses a variety of topics, notably DNA Repair Mechanisms, PARP inhibition in cancer therapy, CRISPR and Genetic Engineering, Genomics and Chromatin Dynamics, Childhood Cancer Survivors' Quality of Life, Acute Lymphoblastic Leukemia research, and Carcinogens and Genotoxicity Assessment.

Frequent publication venues for their work include Nature Cell Biology and Cells, each featuring two of their publications. Other venues include Frontiers in Oncology, British Journal of Radiology, and Frontiers in Genetics.

Recent papers authored or coauthored by Löbrich include:

  • POLθ-mediated end joining is restricted by RAD52 and BRCA2 until the onset of mitosis, 2021, Nature Cell Biology
  • One end to rule them all: Non-homologous end-joining and homologous recombination at DNA double-strand breaks, 2020, British Journal of Radiology
  • Homologous Recombination Subpathways: A Tangle to Resolve, 2021, Frontiers in Genetics
  • ATRX and RECQ5 define distinct homologous recombination subpathways, 2021, Proceedings of the National Academy of Sciences
  • An Assessment of Radiation Doses From Radon Exposures Using a Mouse Model System, 2020, International Journal of Radiation Oncology*Biology*Physics

Löbrich collaborates regularly with several researchers, including Michael Ensminger, Marta Llorens-Agost, Hang Phuong Le, Wolf-Dietrich Heyer, and Anugrah Gawai. These coauthors appear frequently alongside Löbrich in publications.

Best Publications

  • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

    Kai Rothkamm;Markus Löbrich

  • Pathways of DNA double-strand break repair during the mammalian cell cycle.

    Kai Rothkamm;Ines Krüger;Larry H. Thompson;Markus Löbrich

  • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.

    Tom Stiff;Mark O’Driscoll;Nicole Rief;Kuniyoshi Iwabuchi

  • A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci.

    Enriqueta Riballo;Martin Kühne;Nicole Rief;Aidan Doherty

  • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.

    Aaron A. Goodarzi;Angela T. Noon;Dorothee Deckbar;Yael Ziv

  • The impact of a negligent G2/M checkpoint on genomic instability and cancer induction.

    Markus Löbrich;Penny A. Jeggo

  • γH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization

    Markus Löbrich;Atsushi Shibata;Andrea Beucher;Anna Fisher

  • ATM and Artemis promote homologous recombination of radiation-induced DNA double-strand breaks in G2.

    Andrea Beucher;Julie Birraux;Leopoldine Tchouandong;Olivia Barton

  • In vivo formation and repair of DNA double-strand breaks after computed tomography examinations

    Markus Löbrich;Nicole Rief;Martin Kühne;Martina Heckmann

  • Factors determining DNA double-strand break repair pathway choice in G2 phase.

    Atsushi Shibata;Sandro Conrad;Julie Birraux;Verena Geuting

  • A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity

    Martin Kühne;Enriqueta Riballo;Nicole Rief;Kai Rothkamm

  • Ataxia telangiectasia mutated (ATM) is essential for DNA-PKcs phosphorylations at the Thr-2609 cluster upon DNA double strand break.

    Benjamin P.C. Chen;Naoya Uematsu;Junya Kobayashi;Yaniv Lerenthal

  • 53BP1-dependent robust localized KAP-1 phosphorylation is essential for heterochromatic DNA double-strand break repair

    Angela T Noon;Atsushi Shibata;Nicole Rief;Markus Lobrich

  • The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax

    Aaron A. Goodarzi;Penny Jeggo;Markus Lobrich

  • Chromosome breakage after G2 checkpoint release

    Dorothee Deckbar;Julie Birraux;Andrea Krempler;Leopoldine Tchouandong

  • DNA double-strand breaks in heterochromatin elicit fast repair protein recruitment, histone H2AX phosphorylation and relocation to euchromatin

    Burkhard Jakob;Jörn Splinter;Sandro Conrad;Kay-Obbe Voss

  • Non-random distribution of DNA double-strand breaks induced by particle irradiation

    M. Lobrich;P. K. Cooper;B. Rydberg

  • DNA double-strand breaks: their cellular and clinical impact?

    P A Jeggo;M Löbrich

  • Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends

    Markus Lobrich;Bjorn Rydberg;Priscilla K. Cooper

  • Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin

    Andreas Kakarougkas;Amani Ismail;Anna L. Chambers;Enriqueta Riballo

Frequent Co-Authors

Penny A. Jeggo
Penny A. Jeggo University of Sussex
Stephan Achenbach
Stephan Achenbach University of Erlangen-Nuremberg
Tanya T. Paull
Tanya T. Paull The University of Texas at Austin
Paul G. Layer
Paul G. Layer Technical University of Darmstadt
Tej K. Pandita
Tej K. Pandita Houston Methodist
Junjie Chen
Junjie Chen The University of Texas MD Anderson Cancer Center
Benjamin P C Chen
Benjamin P C Chen The University of Texas Southwestern Medical Center
Raj K. Pandita
Raj K. Pandita Houston Methodist
David J. Chen
David J. Chen The University of Texas Southwestern Medical Center
Yosef Shiloh
Yosef Shiloh Tel Aviv University

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