2023 - Research.com Molecular Biology in Sweden Leader Award
2022 - Research.com Genetics and Molecular Biology in Sweden Leader Award
Member of the European Molecular Biology Organization (EMBO)
His scientific interests lie mostly in DNA repair, Molecular biology, DNA replication, Homologous recombination and DNA damage. His DNA repair study integrates concerns from other disciplines, such as Replication protein A, Cancer research and Poly ADP ribose polymerase, PARP1. His Molecular biology study combines topics from a wide range of disciplines, such as Base excision repair, Genetic recombination, Histone code, Histone H2A and Gene conversion.
His DNA replication research includes themes of Cell cycle, Chromosome instability, Aneuploidy and Cell biology. Thomas Helleday has researched Homologous recombination in several fields, including Gene duplication, Homology directed repair, Postreplication repair and Poly Polymerase Inhibitor. His biological study spans a wide range of topics, including Cancer cell, Senescence, DNA fragmentation and Pharmacology.
DNA repair, DNA damage, Cancer research, Molecular biology and DNA are his primary areas of study. His research integrates issues of Poly ADP ribose polymerase and Poly Polymerase Inhibitor in his study of DNA repair. His DNA damage research integrates issues from G2-M DNA damage checkpoint, DNA mismatch repair, DNA replication and Cell biology.
The study incorporates disciplines such as Cancer cell, Cancer, Apoptosis, Programmed cell death and Downregulation and upregulation in addition to Cancer research. The various areas that Thomas Helleday examines in his Molecular biology study include Replication protein A, Nucleotide excision repair, Homologous recombination and Proliferating cell nuclear antigen. His Homologous recombination research focuses on Genetic recombination and how it connects with High-mobility group.
The scientist’s investigation covers issues in Cancer research, DNA, DNA damage, Cancer cell and Biochemistry. Thomas Helleday interconnects Base excision repair, DNA repair, Cancer and Apoptosis in the investigation of issues within Cancer research. His work carried out in the field of DNA repair brings together such families of science as Polymerase, Poly ADP ribose polymerase, Homologous recombination, Proteomics and Messenger RNA.
He combines subjects such as Nucleotide and Cell biology with his study of DNA. DNA damage is frequently linked to Protein subunit in his study. His studies in Mitosis integrate themes in fields like Cell cycle and DNA replication.
Thomas Helleday mostly deals with Cancer research, DNA, DNA repair, DNA damage and Cancer cell. His work deals with themes such as Cancer, Chemotherapy induced, Immunotherapy and Cell culture, which intersect with Cancer research. As a part of the same scientific family, Thomas Helleday mostly works in the field of DNA, focusing on Cell biology and, on occasion, In vitro and Mechanism of action.
Thomas Helleday performs multidisciplinary study on DNA repair and Somatic hypermutation in his works. Thomas Helleday has included themes like Poly ADP ribose polymerase and Pharmacology in his DNA damage study. His Cancer cell study integrates concerns from other disciplines, such as Polymerase, Homologous recombination, Transcriptome, Proteomics and Messenger RNA.
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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
Helen E. Bryant;Nilklas Schultz;Huw D. Thomas;Kayan M. Parker.
Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints
Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos.
DNA repair pathways as targets for cancer therapy
Thomas Helleday;Eva Petermann;Cecilia Lundin;Ben Hodgson.
Nature Reviews Cancer (2008)
DNA double-strand break repair: from mechanistic understanding to cancer treatment.
Thomas Helleday;Justin Lo;Dik C. van Gent;Bevin P. Engelward.
DNA Repair (2007)
Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair
Eva Petermann;Manuel Luís Orta;Manuel Luís Orta;Natalia Issaeva;Niklas Schultz.
Molecular Cell (2010)
Mechanisms underlying mutational signatures in human cancers
Thomas Helleday;Saeed Eshtad;Serena Nik-Zainal.
Nature Reviews Genetics (2014)
Replication stress links structural and numerical cancer chromosomal instability
Rebecca A. Burrell;Sarah E. McClelland;David Endesfelder;Petra Groth.
The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings
Thomas Helleday;Thomas Helleday;Thomas Helleday.
Molecular Oncology (2011)
Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)
RA Burrell;SE McClelland;D Endesfelder;P Groth.
The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair
Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Jaroslaw Dziegielewski;Randi G. Syljuåsen.
Nature Cell Biology (2005)
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