World's Best Scientists 2026 revealed!
Thomas Helleday

Thomas Helleday

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Genetics and Molecular Biology
Sweden
2024
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Molecular Biology
Sweden
2023

D-Index & Metrics

Molecular Biology

D-Index
93
Citations
43601
World Ranking
666
National Ranking
14

Thomas Helleday publication distribution in Molecular Biology in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Molecular Biology in 2026. The highlighted bar marks where Thomas Helleday sits on this spectrum.

47–56 publications: 7 scientists 57–66 publications: 17 scientists 67–76 publications: 65 scientists 77–86 publications: 90 scientists 87–96 publications: 125 scientists 97–106 publications: 131 scientists 107–116 publications: 162 scientists 117–126 publications: 177 scientists 127–136 publications: 158 scientists 137–146 publications: 158 scientists 147–156 publications: 146 scientists 157–166 publications: 159 scientists 167–176 publications: 131 scientists 177–186 publications: 110 scientists 187–196 publications: 112 scientists 197–206 publications: 100 scientists 207–216 publications: 89 scientists 217–226 publications: 98 scientists 227–236 publications: 74 scientists 237–246 publications: 72 scientists 247–256 publications: 63 scientists 257–266 publications: 53 scientists 267–276 publications: 54 scientists 277–286 publications: 49 scientists 287–296 publications: 52 scientists 297–306 publications: 43 scientists 307–316 publications: 46 scientists 317–326 publications: 41 scientists 327–336 publications: 42 scientists 337–346 publications: 31 scientists 347–356 publications: 28 scientists 357–366 publications: 29 scientists 367–376 publications: 26 scientists 377–386 publications: 24 scientists 387–396 publications: 24 scientists 397–406 publications: 14 scientists 407–416 publications: 13 scientists 417–426 publications: 20 scientists 427–436 publications: 12 scientists 437–446 publications: 20 scientists 447–456 publications: 11 scientists 457–466 publications: 10 scientists 467–476 publications: 14 scientists 477–486 publications: 14 scientists 487–496 publications: 10 scientists 497–506 publications: 13 scientists 507–516 publications: 13 scientists 517–526 publications: 2 scientists 527–536 publications: 4 scientists 537–546 publications: 6 scientists 547–556 publications: 8 scientists 557–563 publications: 6 scientists 564+ publications: 100 scientists
47 publications 564+

This scientist: 360 publications — 88th percentile

88% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 564 publications or more.

Thomas Helleday D-index placement in Molecular Biology in 2026

The chart shows the D-index (discipline H-index) distribution of Molecular Biology scientists ranked by Research.com in 2026. The highlighted bar marks where Thomas Helleday sits on this spectrum.

40–41 D-Index: 36 scientists 42–43 D-Index: 101 scientists 44–45 D-Index: 115 scientists 46–47 D-Index: 121 scientists 48–49 D-Index: 118 scientists 50–51 D-Index: 130 scientists 52–53 D-Index: 106 scientists 54–55 D-Index: 116 scientists 56–57 D-Index: 113 scientists 58–59 D-Index: 129 scientists 60–61 D-Index: 120 scientists 62–63 D-Index: 105 scientists 64–65 D-Index: 131 scientists 66–67 D-Index: 95 scientists 68–69 D-Index: 97 scientists 70–71 D-Index: 106 scientists 72–73 D-Index: 83 scientists 74–75 D-Index: 89 scientists 76–77 D-Index: 77 scientists 78–79 D-Index: 70 scientists 80–81 D-Index: 73 scientists 82–83 D-Index: 60 scientists 84–85 D-Index: 48 scientists 86–87 D-Index: 45 scientists 88–89 D-Index: 50 scientists 90–91 D-Index: 31 scientists 92–93 D-Index: 51 scientists 94–95 D-Index: 43 scientists 96–97 D-Index: 38 scientists 98–99 D-Index: 39 scientists 100–101 D-Index: 41 scientists 102–103 D-Index: 29 scientists 104–105 D-Index: 33 scientists 106–107 D-Index: 35 scientists 108–109 D-Index: 20 scientists 110–111 D-Index: 38 scientists 112–113 D-Index: 19 scientists 114–115 D-Index: 28 scientists 116–117 D-Index: 13 scientists 118–119 D-Index: 23 scientists 120–121 D-Index: 16 scientists 122–123 D-Index: 15 scientists 124–125 D-Index: 11 scientists 126–127 D-Index: 21 scientists 128–129 D-Index: 7 scientists 130–131 D-Index: 13 scientists 132–133 D-Index: 14 scientists 134–135 D-Index: 17 scientists 136–137 D-Index: 9 scientists 138–139 D-Index: 8 scientists 140–141 D-Index: 16 scientists 142–143 D-Index: 7 scientists 144 D-Index: 7 scientists 145+ D-Index: 100 scientists
40 D-Index 145+

This scientist: 93 D-Index — 79th percentile

79% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 145 D-Index or more.

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Sweden Leader Award
  • 2023 - Research.com Molecular Biology in Sweden Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Sweden Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thomas Helleday is affiliated with the Karolinska Institute in Sweden and has a significant research output primarily within biochemistry, genetics, and molecular biology as well as medicine. Their work spans various subfields, notably molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and immunology.

The scientist's research focuses on areas such as DNA repair mechanisms, biochemical and molecular research, cancer genomics and diagnostics, PARP inhibition in cancer therapy, cancer therapeutics and mechanisms, RNA modifications and cancer, and epigenetics and DNA methylation.

Recent papers by Thomas Helleday include the following:

  • Spatially resolved clonal copy number alterations in benign and malignant tissue, 2022, Nature
  • Managing COVID-19 in the oncology clinic and avoiding the distraction effect, 2020, Annals of Oncology
  • Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress, 2022, Nature Cancer
  • Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model, 2023, Nature Communications
  • Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function, 2022, Science

Thomas Helleday frequently publishes in several venues, including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Nature Communications
  • Annals of Oncology

Frequent co-authors collaborating with Thomas Helleday are:

  • Ulrika Warpman Berglund
  • Pål Stenmark
  • Ann-Sofie Jemth
  • Evert Homan
  • Olov Wallner

Thomas Helleday has been recognized as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

    Helen E. Bryant;Nilklas Schultz;Huw D. Thomas;Kayan M. Parker

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

  • DNA repair pathways as targets for cancer therapy

    Thomas Helleday;Eva Petermann;Cecilia Lundin;Ben Hodgson

  • Replication stress links structural and numerical cancer chromosomal instability

    Rebecca A. Burrell;Sarah E. McClelland;David Endesfelder;Petra Groth

  • Mechanisms underlying mutational signatures in human cancers

    Thomas Helleday;Saeed Eshtad;Serena Nik-Zainal

  • Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

    Eva Petermann;Manuel Luís Orta;Manuel Luís Orta;Natalia Issaeva;Niklas Schultz

  • The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

    Thomas Helleday;Thomas Helleday;Thomas Helleday

  • DNA double-strand break repair: from mechanistic understanding to cancer treatment.

    Thomas Helleday;Justin Lo;Dik C. van Gent;Bevin P. Engelward

  • The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

    Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Jaroslaw Dziegielewski;Randi G. Syljuåsen

  • Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)

    RA Burrell;SE McClelland;D Endesfelder;P Groth

  • PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

    Helen E Bryant;Eva Petermann;Niklas Schultz;Ann-Sofie Jemth

  • Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

    Randi G. Syljuåsen;Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Kasper Fugger

  • Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

    Emelie Berglund;Jonas Maaskola;Niklas Schultz;Stefanie Friedrich

  • MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

    Helge Gad;Tobias Koolmeister;Ann-Sofie Jemth;Saeed Eshtad

  • miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

    Patryk Moskwa;Francesca M. Buffa;Yunfeng Pan;Rohit Panchakshari

  • DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells.

    Catherine Arnaudeau;Cecilia Lundin;Thomas Helleday;Thomas Helleday

  • Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

    Lorenzo Costantino;Sotirios K. Sotiriou;Juha K. Rantala;Simon Magin

  • Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

    Cecilia Lundin;Matthew North;Klaus Erixon;Kevin Walters

  • Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

    Sherif F. El-Khamisy;Gulam M. Saifi;Michael Weinfeld;Fredrik Johansson

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

Frequent Co-Authors

Per Artursson
Per Artursson Uppsala University
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Mark Meuth
Mark Meuth University of Sheffield
Nicola J. Curtin
Nicola J. Curtin Newcastle University
Claus Storgaard Sørensen
Claus Storgaard Sørensen University of Copenhagen
Erik L. L. Sonnhammer
Erik L. L. Sonnhammer Stockholm University
Robert G. Bristow
Robert G. Bristow University of Manchester
Jiri Bartek
Jiri Bartek Karolinska Institute
Roman A. Zubarev
Roman A. Zubarev Karolinska Institute
Jan-Inge Henter
Jan-Inge Henter Karolinska University Hospital

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