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Thomas Helleday

Thomas Helleday

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Genetics and Molecular Biology
Sweden
2024
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Molecular Biology
Sweden
2023

D-Index & Metrics

Molecular Biology

D-Index
93
Citations
43601
World Ranking
666
National Ranking
14

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Sweden Leader Award
  • 2023 - Research.com Molecular Biology in Sweden Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Sweden Leader Award
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thomas Helleday is affiliated with the Karolinska Institute in Sweden and has a significant research output primarily within biochemistry, genetics, and molecular biology as well as medicine. Their work spans various subfields, notably molecular biology, oncology, pulmonary and respiratory medicine, cancer research, and immunology.

The scientist's research focuses on areas such as DNA repair mechanisms, biochemical and molecular research, cancer genomics and diagnostics, PARP inhibition in cancer therapy, cancer therapeutics and mechanisms, RNA modifications and cancer, and epigenetics and DNA methylation.

Recent papers by Thomas Helleday include the following:

  • Spatially resolved clonal copy number alterations in benign and malignant tissue, 2022, Nature
  • Managing COVID-19 in the oncology clinic and avoiding the distraction effect, 2020, Annals of Oncology
  • Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress, 2022, Nature Cancer
  • Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model, 2023, Nature Communications
  • Small-molecule activation of OGG1 increases oxidative DNA damage repair by gaining a new function, 2022, Science

Thomas Helleday frequently publishes in several venues, including:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Nature Communications
  • Annals of Oncology

Frequent co-authors collaborating with Thomas Helleday are:

  • Ulrika Warpman Berglund
  • Pål Stenmark
  • Ann-Sofie Jemth
  • Evert Homan
  • Olov Wallner

Thomas Helleday has been recognized as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

    Helen E. Bryant;Nilklas Schultz;Huw D. Thomas;Kayan M. Parker

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

  • DNA repair pathways as targets for cancer therapy

    Thomas Helleday;Eva Petermann;Cecilia Lundin;Ben Hodgson

  • Replication stress links structural and numerical cancer chromosomal instability

    Rebecca A. Burrell;Sarah E. McClelland;David Endesfelder;Petra Groth

  • Mechanisms underlying mutational signatures in human cancers

    Thomas Helleday;Saeed Eshtad;Serena Nik-Zainal

  • Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

    Eva Petermann;Manuel Luís Orta;Manuel Luís Orta;Natalia Issaeva;Niklas Schultz

  • The underlying mechanism for the PARP and BRCA synthetic lethality: Clearing up the misunderstandings

    Thomas Helleday;Thomas Helleday;Thomas Helleday

  • DNA double-strand break repair: from mechanistic understanding to cancer treatment.

    Thomas Helleday;Justin Lo;Dik C. van Gent;Bevin P. Engelward

  • The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

    Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Jaroslaw Dziegielewski;Randi G. Syljuåsen

  • Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)

    RA Burrell;SE McClelland;D Endesfelder;P Groth

  • PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination.

    Helen E Bryant;Eva Petermann;Niklas Schultz;Ann-Sofie Jemth

  • Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

    Randi G. Syljuåsen;Claus Storgaard Sørensen;Lasse Tengbjerg Hansen;Kasper Fugger

  • Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity

    Emelie Berglund;Jonas Maaskola;Niklas Schultz;Stefanie Friedrich

  • MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool

    Helge Gad;Tobias Koolmeister;Ann-Sofie Jemth;Saeed Eshtad

  • miR-182-Mediated Downregulation of BRCA1 Impacts DNA Repair and Sensitivity to PARP Inhibitors

    Patryk Moskwa;Francesca M. Buffa;Yunfeng Pan;Rohit Panchakshari

  • DNA double-strand breaks associated with replication forks are predominantly repaired by homologous recombination involving an exchange mechanism in mammalian cells.

    Catherine Arnaudeau;Cecilia Lundin;Thomas Helleday;Thomas Helleday

  • Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

    Lorenzo Costantino;Sotirios K. Sotiriou;Juha K. Rantala;Simon Magin

  • Methyl methanesulfonate (MMS) produces heat-labile DNA damage but no detectable in vivo DNA double-strand breaks

    Cecilia Lundin;Matthew North;Klaus Erixon;Kevin Walters

  • Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1

    Sherif F. El-Khamisy;Gulam M. Saifi;Michael Weinfeld;Fredrik Johansson

  • Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage

    Jirina Bartkova;Nousin Rezaei;Michalis Liontos;Panagiotis Karakaidos

Frequent Co-Authors

Per Artursson
Per Artursson Uppsala University
Vassilis G. Gorgoulis
Vassilis G. Gorgoulis National and Kapodistrian University of Athens
Mark Meuth
Mark Meuth University of Sheffield
Nicola J. Curtin
Nicola J. Curtin Newcastle University
Claus Storgaard Sørensen
Claus Storgaard Sørensen University of Copenhagen
Erik L. L. Sonnhammer
Erik L. L. Sonnhammer Stockholm University
Robert G. Bristow
Robert G. Bristow University of Manchester
Jiri Bartek
Jiri Bartek Karolinska Institute
Roman A. Zubarev
Roman A. Zubarev Karolinska Institute
Jan-Inge Henter
Jan-Inge Henter Karolinska University Hospital

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