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Molecular Biology
USA
2026
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Genetics and Molecular Biology
USA
2024

D-Index & Metrics

Molecular Biology

D-Index
160
Citations
92127
World Ranking
64
National Ranking
43

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2017 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Yves Pommier is affiliated with the National Institutes of Health in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with 311 publications, as well as Medicine, with 199 publications. Within these domains, Pommier has contributed extensively to subfields including Molecular Biology, Oncology, Cancer Research, Organic Chemistry, and Epidemiology.

Their main research topics cover a range of areas related to cancer biology and cellular processes, notably:

  • Cancer therapeutics and mechanisms
  • DNA Repair Mechanisms
  • Lung Cancer Research Studies
  • PARP inhibition in cancer therapy
  • Cancer Genomics and Diagnostics
  • Neuroendocrine Tumor Research Advances
  • Epigenetics and DNA Methylation

Pommier's recent papers include the following publications:

  • Human topoisomerases and their roles in genome stability and organization, 2022, Nature Reviews Molecular Cell Biology
  • MGMT Status as a Clinical Biomarker in Glioblastoma, 2020, Trends in cancer
  • Genomic and evolutionary classification of lung cancer in never smokers, 2021, Nature Genetics
  • CellMiner Cross-Database (CellMinerCDB) version 1.2: Exploration of patient-derived cancer cell line pharmacogenomics, 2020, Nucleic Acids Research
  • New Approaches to SCLC Therapy: From the Laboratory to the Clinic, 2020, Journal of Thoracic Oncology

Frequent co-authors collaborating with Pommier include:

  • Anish Thomas (38 joint publications)
  • Yilun Sun (38 joint publications)
  • Mirit I. Aladjem (33 joint publications)
  • William C. Reinhold (30 joint publications)
  • Ukhyun Jo (27 joint publications)

Major venues where their work has been published frequently are:

  • Cancer Research (16 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (16 publications)
  • Molecular Cancer Therapeutics (11 publications)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature (10 publications)
  • Nature Communications (7 publications)

Yves Pommier has been recognized as a Fellow of the American Association for the Advancement of Science (AAAS) in 2017.

Best Publications

  • DNA topoisomerases and their poisoning by anticancer and antibacterial drugs.

    Yves Pommier;Elisabetta Leo;HongLiang Zhang;Christophe Marchand

  • γH2AX and cancer

    William M. Bonner;Christophe E. Redon;Jennifer S. Dickey;Asako J. Nakamura

  • Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

    Junko Murai;Shar Yin N. Huang;Benu Brata Das;Amelie Renaud

  • A gene expression database for the molecular pharmacology of cancer

    Uwe Scherf;Douglas T. Ross;Mark Waltham;Lawrence H. Smith

  • Drugging Topoisomerases: Lessons and Challenges

    Yves Pommier

  • CellMiner: a web-based suite of genomic and pharmacologic tools to explore transcript and drug patterns in the NCI-60 cell line set

    William C. Reinhold;Margot Sunshine;Margot Sunshine;Hongfang Liu;Sudhir Varma

  • DNA Topoisomerase I Inhibitors: Chemistry, Biology and Interfacial Inhibition

    Yves Pommier

  • Initiation of DNA Fragmentation during Apoptosis Induces Phosphorylation of H2AX Histone at Serine 139

    Emmy P. Rogakou;Wilberto Nieves-Neira;Chye Boon;Yves Pommier

  • Roles of eukaryotic topoisomerases in transcription, replication and genomic stability

    Yves Pommier;Yilun Sun;Shar Yin N Huang;John L. Nitiss

  • MECHANISM OF ACTION OF EUKARYOTIC DNA TOPOISOMERASE I AND DRUGS TARGETED TO THE ENZYME

    Yves Pommier;Philippe Pourquier;Yi Fan;Dirk Strumberg

  • Stereospecific PARP Trapping by BMN 673 and Comparison with Olaparib and Rucaparib

    Junko Murai;Shar-yin N. Huang;Amèlie Renaud;Yiping Zhang

  • Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks

    Yves Pommier;Olivier Sordet;Smitha Antony;Richard L Hayward

  • Structure-Activity Study of the Actions of Camptothecin Derivatives on Mammalian Topoisomerase I: Evidence for a Specific Receptor Site and a Relation to Antitumor Activity

    Christine Jaxel;Kurt W. Kohn;Mansukh C. Wani;Monroe E. Wall

  • Induction of a common pathway of apoptosis by staurosporine

    Richard Bertrand;Eric Solary;Patrick O'Connor;Kurt W. Kohn

  • Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action

    Yves Pommier;Mark J. O’Connor;Johann de Bono

  • Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA

    Myoung Sook Kim;Mellissa Blake;Jin Hyen Baek;Glenda Kohlhagen

  • Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes

    Takahisa Furuta;Haruyuki Takemura;Zhi Yong Liao;Gregory J. Aune

  • Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

    Bart L. Staker;Michael D. Feese;Mark Cushman;Yves Pommier

  • Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

    Sandie Tuduri;Sandie Tuduri;Laure Crabbé;Chiara Conti;Hélène Tourrière

  • Differential Requirement of DNA Replication for the Cytotoxicity of DNA Topoisomerase I and II Inhibitors in Chinese Hamster DC3F Cells

    Christine Holm;Joseph M. Covey;Donna Kerrigan;Yves Pommier

Frequent Co-Authors

Christophe Marchand
Christophe Marchand National Institutes of Health
Kurt W. Kohn
Kurt W. Kohn National Institutes of Health
William C. Reinhold
William C. Reinhold National Institutes of Health
Glenda Kohlhagen
Glenda Kohlhagen National Institutes of Health
Mark Cushman
Mark Cushman Purdue University West Lafayette
James H. Doroshow
James H. Doroshow National Institutes of Health
Terrence R. Burke
Terrence R. Burke National Institutes of Health
John N. Weinstein
John N. Weinstein The University of Texas MD Anderson Cancer Center
Mirit I. Aladjem
Mirit I. Aladjem National Institutes of Health
Christophe E. Redon
Christophe E. Redon National Institutes of Health

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