What is he best known for?
The fields of study he is best known for:
- Enzyme
- Organic chemistry
- Gene
His primary areas of study are Stereochemistry, Biochemistry, Topoisomerase, Topoisomerase-I Inhibitor and Camptothecin.
His Stereochemistry research incorporates elements of Enzyme inhibitor, Enzyme, Biological activity, Structure–activity relationship and Chemical synthesis.
His Biochemistry research integrates issues from Cancer cell, Cell culture and Tubulin.
His work carried out in the field of Topoisomerase brings together such families of science as Lactam, Cleavage, Isoquinoline and Cytotoxicity.
His Topoisomerase-I Inhibitor study integrates concerns from other disciplines, such as Combinatorial chemistry, Base pair, Molecular model and Hydrogen bond.
His Camptothecin study combines topics from a wide range of disciplines, such as DNA damage and Point mutation.
His most cited work include:
- Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex (327 citations)
- Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization. (304 citations)
- Synthesis and evaluation of analogues of (Z)-1-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)ethene as potential cytotoxic and antimitotic agents. (210 citations)
What are the main themes of his work throughout his whole career to date?
Mark Cushman mainly investigates Stereochemistry, Biochemistry, Topoisomerase, Cytotoxicity and Topoisomerase-I Inhibitor.
The Stereochemistry study combines topics in areas such as Lumazine synthase, Enzyme, Riboflavin synthase, Structure–activity relationship and Chemical synthesis.
His work in Biochemistry addresses issues such as Cancer cell, which are connected to fields such as Cancer research.
His Topoisomerase research integrates issues from Camptothecin, Cleavage, Lactam and Isoquinoline.
The study incorporates disciplines such as Cell culture and Biological activity in addition to Cytotoxicity.
His research in Topoisomerase-I Inhibitor intersects with topics in Combinatorial chemistry and Molecular model.
He most often published in these fields:
- Stereochemistry (48.24%)
- Biochemistry (22.72%)
- Topoisomerase (20.14%)
What were the highlights of his more recent work (between 2012-2021)?
- Topoisomerase (20.14%)
- Stereochemistry (48.24%)
- Pharmacology (7.03%)
In recent papers he was focusing on the following fields of study:
His main research concerns Topoisomerase, Stereochemistry, Pharmacology, Biochemistry and Cancer research.
Mark Cushman has included themes like Camptothecin, Cancer cell and Cytotoxicity in his Topoisomerase study.
Mark Cushman combines subjects such as Lactam and Cell culture with his study of Cytotoxicity.
His work carried out in the field of Stereochemistry brings together such families of science as Telithromycin, Biological activity, Staphylococcus aureus, Ketolide and Structure–activity relationship.
His DNA, DNA damage and Coenzyme A study in the realm of Biochemistry connects with subjects such as Methylenedioxy.
The concepts of his Topoisomerase-I Inhibitor study are interwoven with issues in Side chain and Mechanism of action.
Between 2012 and 2021, his most popular works were:
- Discovery and Characterization of Potent Thiazoles versus Methicillin- and Vancomycin-Resistant Staphylococcus aureus (64 citations)
- MAIT Recognition of a Stimulatory Bacterial Antigen Bound to MR1 (61 citations)
- Anti-biofilm activity and synergism of novel thiazole compounds with glycopeptide antibiotics against multidrug-resistant Staphylococci (53 citations)
In his most recent research, the most cited papers focused on:
- Enzyme
- Organic chemistry
- Gene
The scientist’s investigation covers issues in Topoisomerase, Cytotoxicity, Biochemistry, Topoisomerase-I Inhibitor and Stereochemistry.
Topoisomerase connects with themes related to Pharmacology in his study.
His Cytotoxicity research is multidisciplinary, relying on both Lactam, Cell culture, DNA, DNA damage and Cancer cell.
His Biochemistry research incorporates themes from Triazine and Antibacterial activity.
His research integrates issues of Camptothecin, IC50, Cancer research and Structure–activity relationship in his study of Topoisomerase-I Inhibitor.
His Stereochemistry study incorporates themes from Biological activity, Dna cleavage, Cleavage, Tyrosyl-DNA phosphodiesterase and Side chain.
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