World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
76
Citations
17843
World Ranking
4324
National Ranking
1365

Research.com Recognitions

  • 2018 - Fellow, National Academy of Inventors

Overview

Mark Cushman is affiliated with Purdue University West Lafayette in the United States. Their research primarily focuses on the fields of biochemistry, genetics, and molecular biology, with significant contributions in molecular biology, organic chemistry, infectious diseases, toxicology, and molecular medicine. The main topics addressed in their work include cancer therapeutics and mechanisms, DNA and nucleic acid chemistry, bioactive compounds and antitumor agents, synthesis and biological activity, antibiotic resistance in bacteria, antimicrobial resistance in Staphylococcus, and HIV/AIDS drug development and treatment.

Recent papers published by Mark Cushman include:

  • Design and Synthesis of Indenoisoquinolines Targeting Topoisomerase I and Other Biological Macromolecules for Cancer Chemotherapy (2021, Journal of Medicinal Chemistry)
  • Design, synthesis and structure-activity relationships of novel 15-membered macrolides: Quinolone/quinoline-containing sidechains tethered to the C-6 position of azithromycin acylides (2020, European Journal of Medicinal Chemistry)
  • Design, Synthesis, and Investigation of the Pharmacokinetics and Anticancer Activities of Indenoisoquinoline Derivatives That Stabilize the G-Quadruplex in the MYC Promoter and Inhibit Topoisomerase I (2024, Journal of Medicinal Chemistry)
  • Design and synthesis of novel macrolones bridged with linkers from 11,12-positions of macrolides (2022, Bioorganic & Medicinal Chemistry Letters)
  • Abstract 3103: Dual targeting MYC G-quadruplex and topoisomerase I by indenoisoquinolines for cancer therapy (2023, Cancer Research)

Mark Cushman has published frequently in the following venues:

  • Journal of Medicinal Chemistry
  • Cancer Research
  • European Journal of Medicinal Chemistry
  • Bioorganic & Medicinal Chemistry Letters

Their frequent co-authors include:

  • Danzhou Yang
  • Wei Lv
  • Jian-Hua Liang
  • Yichen Han
  • Adam J. Buric

Mark Cushman was named a Fellow of the National Academy of Inventors in 2018.

Best Publications

  • Structures of three classes of anticancer agents bound to the human topoisomerase I-DNA covalent complex

    Bart L. Staker;Michael D. Feese;Mark Cushman;Yves Pommier

  • Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization.

    Mark Cushman;Dhanapalan Nagarathnam;D. Gopal;Asit K. Chakraborti

  • Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

    Mark Cushman;Hu Ming He;John A. Katzenellenbogen;Chii M. Lin

  • Selective Synthesis and Biological Evaluation of Sulfate-Conjugated Resveratrol Metabolites

    Juma Hoshino;Eun Jung Park;Tamara P. Kondratyuk;Laura Marler

  • Synthesis and protein-tyrosine kinase inhibitory activity of polyhydroxylated stilbene analogues of piceatannol.

    Kshitij Thakkar;Robert L. Geahlen;Mark Cushman

  • Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

    Glenda Kohlhagen;Kenneth D. Paull;Mark Cushman;Pamela Nagafuji

  • Synthesis of new indeno[1,2-c]isoquinolines: cytotoxic non-camptothecin topoisomerase I inhibitors.

    Mark Cushman;Muthusamy Jayaraman;Jeffrey A. Vroman;Anna K. Fukunaga

  • The indenoisoquinoline noncamptothecin topoisomerase I inhibitors: update and perspectives.

    Yves Pommier;Mark Cushman

  • A novel norindenoisoquinoline structure reveals a common interfacial inhibitor paradigm for ternary trapping of the topoisomerase I-DNA covalent complex

    Christophe Marchand;Smitha Antony;Kurt W. Kohn;Mark Cushman

  • Condensation of imines with homophthalic anhydrides. A convergent synthesis of cis- and trans-13-methyltetrahydroprotoberberines.

    Mark Cushman;John Gentry;Frederick W. Dekow

  • Synthesis of Cytotoxic Indenoisoquinoline Topoisomerase I Poisons

    Dirk Strumberg;Yves Pommier;Kenneth Paull;Muthusamy Jayaraman

  • Design, Synthesis, and Biological Evaluation of Indenoisoquinoline Topoisomerase I Inhibitors Featuring Polyamine Side Chains on the Lactam Nitrogen

    Muthukaman Nagarajan;Xiangshu Xiao;Smitha Antony;Glenda Kohlhagen

  • Synergistic effects of peloruside A and laulimalide with taxoid site drugs, but not with each other, on tubulin assembly.

    Ernest Hamel;Billy W. Day;John H. Miller;M. Katherine Jung

  • Synthesis and anticancer activity of simplified indenoisoquinoline topoisomerase I inhibitors lacking substituents on the aromatic rings.

    Muthukaman Nagarajan;Andrew Morrell;Brian C Fort;Marintha Rae Meckley

  • Differential Induction of Topoisomerase I-DNA Cleavage Complexes by the Indenoisoquinoline MJ-III-65 (NSC 706744) and Camptothecin: Base Sequence Analysis and Activity against Camptothecin- Resistant Topoisomerases I

    Smitha Antony;Muthusamy Jayaraman;Gary Laco;Glenda Kohlhagen

  • Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogues: direct correlation of antiviral potency with molecular weight.

    Mark Cushman;Pinglang Wang;Steve H. Chang;Carl Wild

  • Synthesis and Mechanism of Action Studies of a Series of Norindenoisoquinoline Topoisomerase I Poisons Reveal an Inhibitor with a Flipped Orientation in the Ternary DNA-Enzyme-Inhibitor Complex As Determined by X-ray Crystallographic Analysis

    Alexandra Ioanoviciu;Smitha Antony;Yves Pommier;Bart L. Staker

  • Design, Synthesis, and Biological Evaluation of Antiviral Agents Targeting Flavivirus Envelope Proteins

    Ze Li;Mansoora Khaliq;Zhigang Zhou;Carol Beth Post

  • Novel Indenoisoquinolines NSC 725776 and NSC 724998 Produce Persistent Topoisomerase I Cleavage Complexes and Overcome Multidrug Resistance

    Smitha Antony;Keli K. Agama;Ze-Hong Miao;Kazutaka Takagi

  • Synthesis and biochemical evaluation of a series of aminoflavones as potential inhibitors of protein-tyrosine kinases p56lck, EGFr, and p60v-src.

    Mark Cushman;Helen Zhu;Robert L. Geahlen;Alan J. Kraker

Frequent Co-Authors

Yves Pommier
Yves Pommier National Institutes of Health
Adelbert Bacher
Adelbert Bacher Technical University of Munich
Markus Fischer
Markus Fischer Universität Hamburg
John M. Pezzuto
John M. Pezzuto Western New England University
Christophe Pannecouque
Christophe Pannecouque Rega Institute for Medical Research
Erik De Clercq
Erik De Clercq Rega Institute for Medical Research
Ernest Hamel
Ernest Hamel National Institutes of Health
Glenda Kohlhagen
Glenda Kohlhagen National Institutes of Health
Robert Huber
Robert Huber University of Duisburg-Essen
Robert W. Buckheit
Robert W. Buckheit ImQuest BioSciences (United States)

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

For students studying Chemistry in the USA, exploring related online degrees can open up diverse career pathways. For example, obtaining a paralegal studies associate degree can provide a solid foundation if you're interested in legal aspects of chemical patents or regulatory compliance.

Another promising avenue is the pharmaceutical industry, where roles like pharmaceutical sales representatives combine scientific knowledge with business skills. Understanding the pharmaceutical sales salary can help gauge the financial benefits of this career path.

If you wish to advance further, becoming a pharmacist requires substantial education and investment. Knowing how much does it cost to become a pharmacist is crucial for planning your academic journey and financial commitment.

For those interested in forensic science, careers like an autopsy technician offer unique opportunities to apply chemistry in medical investigations. Learning how to become an autopsy technician can provide insight into the education and career outlook requirements in this specialized field.

Best Scientists Citing Mark Cushman

Trending Scientists