2018 - Fellow, National Academy of Inventors
The scientist’s investigation covers issues in Stereochemistry, Topoisomerase, Cytotoxicity, DNA and Biochemistry. He works on Stereochemistry which deals in particular with Moiety. His Topoisomerase research is under the purview of Enzyme.
His Cytotoxicity research includes themes of Camptothecin, Cytotoxic T cell, Relative potency and Enzyme inhibitor. His research in the fields of A-DNA overlaps with other disciplines such as Ligand and Type II topoisomerase. His research integrates issues of Cell culture and Lymphoblast in his study of Biochemistry.
Edmond J. LaVoie spends much of his time researching Stereochemistry, Topoisomerase, Biochemistry, Cytotoxicity and DNA. His Stereochemistry study incorporates themes from G-quadruplex, Biological activity, Chemical synthesis and Enzyme. His studies in Chemical synthesis integrate themes in fields like Lactam, Methylenedioxy and Carboxamide.
In his study, Pharmacology is inextricably linked to Camptothecin, which falls within the broad field of Topoisomerase. His Biochemistry research is multidisciplinary, incorporating elements of Ratón and Staphylococcus aureus. His Cytotoxicity study frequently draws connections to other fields, such as In vivo.
His primary areas of investigation include Stereochemistry, FtsZ, Staphylococcus aureus, Biochemistry and Antibiotics. The concepts of his Stereochemistry study are interwoven with issues in Enzyme, Endonuclease, Active site, Combinatorial chemistry and Structure–activity relationship. His FtsZ research incorporates themes from Antibacterial activity, Bacterial cell structure, Bacteria and Enterococcus faecalis.
His Biochemistry study frequently links to other fields, such as Gram. His Antibiotics study combines topics in areas such as Skin infection, Pharmacology and In vivo. His research investigates the connection with Pharmacology and areas like Cancer which intersect with concerns in Oncology, Biomedical engineering, Phenanthridine and Topoisomerase.
His main research concerns Stereochemistry, Antibiotics, FtsZ, Staphylococcus aureus and Pharmacology. Edmond J. LaVoie has researched Stereochemistry in several fields, including Enzyme, Biochemistry, Endonuclease and Active site. His Biochemistry research incorporates elements of Cell culture and Moiety.
His Antibiotics study integrates concerns from other disciplines, such as Combinatorial chemistry and Quinoxaline. His FtsZ research focuses on subjects like Antibacterial activity, which are linked to Enterococcus faecalis, Bacterial cell structure, Sanguinarine, Methicillin resistance and Gram-positive bacterial infections. His Pharmacology research is multidisciplinary, incorporating perspectives in Camptothecin and In vivo.
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Bioisosterism: A Rational Approach in Drug Design.
George A. Patani;Edmond J. LaVoie.
Chemical Reviews (1996)
Antioxidative Phenolic Compounds from Sage (Salvia officinalis)
Mingfu Wang;Jiangang Li;Meera Rangarajan;Yu Shao.
Journal of Agricultural and Food Chemistry (1998)
Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.
Jung Sun Kim;Barbara Gatto;Chiang Yu;Angela Liu.
Journal of Medicinal Chemistry (1996)
Identification of Topoisomerase I as the Cytotoxic Target of the Protoberberine Alkaloid Coralyne
Barbara Gatto;Marilyn M. Sanders;Chiang Yu;Hong Yan Wu.
Cancer Research (1996)
Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.
Huimin Wang;Yong Mao;Allan Y. Chen;Nai Zhou.
Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons
Jung Sun Kim;Qun Sun;Barbara Gatto;Chiang Yu.
Bioorganic & Medicinal Chemistry (1996)
Antioxidative phenolic glycosides from sage (Salvia officinalis).
Mingfu Wang;Yu Shao;Jiangang Li;Nanqun Zhu.
Journal of Natural Products (1999)
5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.
Alexander L. Ruchelman;Peter J. Houghton;Nai Zhou;Angela Liu.
Journal of Medicinal Chemistry (2005)
Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines
Ajit K. Parhi;Yongzheng Zhang;Kurt W. Saionz;Padmanava Pradhan.
Bioorganic & Medicinal Chemistry Letters (2013)
Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs
Daniel S. Pilch;Chiang Yu;Darshan Makhey;Edmond J. LaVoie.
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