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Chemistry

D-Index
55
Citations
11209
World Ranking
12094
National Ranking
3241

Research.com Recognitions

  • 2018 - Fellow, National Academy of Inventors

Overview

Edmond J. LaVoie is affiliated with Rutgers, The State University of New Jersey in the United States. Their research primarily focuses on Biochemistry, Genetics, and Molecular Biology, with particular attention to subfields such as Molecular Medicine, Genetics, Molecular Biology, and Infectious Diseases.

The main topics of their scholarly work include:

  • Antibiotic Resistance in Bacteria
  • Bacterial Genetics and Biotechnology
  • Bacterial biofilms and quorum sensing
  • Antimicrobial Resistance in Staphylococcus
  • Cancer therapeutics and mechanisms
  • Advanced biosensing and bioanalysis techniques

Edmond J. LaVoie has authored multiple papers, with recent publications spanning from 2022 to 2024. Notable papers include:

  • "TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens" (2022, Antibiotics)
  • "Structural and Antibacterial Characterization of a New Benzamide FtsZ Inhibitor with Superior Bactericidal Activity and In Vivo Efficacy Against Multidrug-Resistant Staphylococcus aureus" (2023, ACS Chemical Biology)
  • "Combination with a FtsZ inhibitor potentiates the in vivo efficacy of oxacillin against methicillin-resistant Staphylococcus aureus" (2022, Medicinal Chemistry Research)
  • "A FtsZ Inhibitor That Can Utilize Siderophore-Ferric Iron Uptake Transporter Systems for Activity against Gram-Negative Bacterial Pathogens" (2024, Antibiotics)
  • "Novel MreB inhibitors with antibacterial activity against Gram (-) bacteria" (2022, Medicinal Chemistry Research)

Frequent co-authors collaborating with Edmond J. LaVoie include:

  • Daniel S. Pilch
  • Eric J. Bryan
  • H.-Y. Sagong
  • Ajit K. Parhi
  • Edgar Ferrer-González

Their work has been published primarily in the journals:

  • Antibiotics
  • Medicinal Chemistry Research
  • ACS Chemical Biology

Edmond J. LaVoie was recognized as a Fellow of the National Academy of Inventors in 2018.

Best Publications

  • Bioisosterism: A Rational Approach in Drug Design.

    George A. Patani;Edmond J. LaVoie

  • Antioxidative Phenolic Compounds from Sage (Salvia officinalis)

    Mingfu Wang;Jiangang Li;Meera Rangarajan;Yu Shao

  • Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.

    Jung Sun Kim;Barbara Gatto;Chiang Yu;Angela Liu

  • Identification of Topoisomerase I as the Cytotoxic Target of the Protoberberine Alkaloid Coralyne

    Barbara Gatto;Marilyn M. Sanders;Chiang Yu;Hong Yan Wu

  • Stimulation of topoisomerase II-mediated DNA damage via a mechanism involving protein thiolation.

    Huimin Wang;Yong Mao;Allan Y. Chen;Nai Zhou

  • Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons

    Jung Sun Kim;Qun Sun;Barbara Gatto;Chiang Yu

  • Antibacterial activity of quinoxalines, quinazolines, and 1,5-naphthyridines

    Ajit K. Parhi;Yongzheng Zhang;Kurt W. Saionz;Padmanava Pradhan

  • 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance.

    Alexander L. Ruchelman;Peter J. Houghton;Nai Zhou;Angela Liu

  • Antioxidative phenolic glycosides from sage (Salvia officinalis).

    Mingfu Wang;Yu Shao;Jiangang Li;Nanqun Zhu

  • Minor groove-directed and intercalative ligand-DNA interactions in the poisoning of human DNA topoisomerase I by protoberberine analogs

    Daniel S. Pilch;Chiang Yu;Darshan Makhey;Edmond J. LaVoie

  • TXA709, an FtsZ-Targeting Benzamide Prodrug with Improved Pharmacokinetics and Enhanced In Vivo Efficacy against Methicillin-Resistant Staphylococcus aureus

    Malvika Kaul;Lilly Mark;Yongzheng Zhang;Ajit K. Parhi

  • Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

    Darshan Makhey;Barbara Gatto;Chiang Yu;Angela Liu

  • Synthesis and evaluation of terbenzimidazoles as topoisomerase I inhibitors

    Qun Sun;Barbara Gatto;Chiang Yu;Angela Liu

  • Human topoisomerase I poisoning by protoberberines: potential roles for both drug-DNA and drug-enzyme interactions.

    Tsai K. Li;Eleanor Bathory;Edmond J. LaVoie;A. R. Srinivasan

  • 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-Targeting anticancer agents with potent cytotoxic activity

    Alexander L. Ruchelman;Sudhir K. Singh;Abhijit Ray;Xiao Hua Wu

  • Characterization of ARC-111 as a Novel Topoisomerase I-Targeting Anticancer Drug

    Tsai Kun Li;Peter J. Houghton;Shyamal D. Desai;Parima Daroui

  • Determination of the Predominant Catechins in Acacia catechu by Liquid Chromatography/Electrospray Ionization−Mass Spectrometry

    Diandian Shen;Qingli Wu;Mingfu Wang;Yonghong Yang

  • Substituted dibenzo[c, h]cinnolines: Topoisomerase I-targeting anticancer agents

    Younong Yu;Sudhir K. Singh;Angela Liu;Tsai Kun Li

  • ANTIOXIDATIVE FLAVONOID GLYCOSIDES FROM QUINOA SEEDS (CHENOPODIUM QUINOA WILLD)

    Nanqun Zhu;Shuqun Sheng;Dajie Li;Edmond J. Lavoie

  • Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

    Gurpreet Singh Minhas;Daniel S. Pilch;John E. Kerrigan;Edmond J. LaVoie

Frequent Co-Authors

Leroy F. Liu
Leroy F. Liu Taipei Medical University
Daniel S. Pilch
Daniel S. Pilch Rutgers, The State University of New Jersey
Eddy Arnold
Eddy Arnold Rutgers, The State University of New Jersey
Kalyan Das
Kalyan Das Rega Institute for Medical Research
Chi-Tang Ho
Chi-Tang Ho Rutgers, The State University of New Jersey
Kenneth J. Breslauer
Kenneth J. Breslauer Rutgers, The State University of New Jersey
Mingfu Wang
Mingfu Wang University of Hong Kong
Robert T. Rosen
Robert T. Rosen Rutgers, The State University of New Jersey
Wilma K. Olson
Wilma K. Olson Rutgers, The State University of New Jersey
Luis Martínez-Sobrido
Luis Martínez-Sobrido Texas Biomedical Research Institute

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