What is he best known for?
The fields of study he is best known for:
- Organic chemistry
- Enzyme
- Hydrogen
His scientific interests lie mostly in Tautomer, Organic chemistry, Enzyme, Stereochemistry and Xanthine.
His Tautomer study combines topics in areas such as Combinatorial chemistry and Prodrug.
His work in the fields of Organic chemistry, such as Scientific method, overlaps with other areas such as Benzene derivatives.
His work deals with themes such as Enantiomer, Inhibitory effect and Diastereomer, which intersect with Enzyme.
His Stereochemistry research integrates issues from Oral administration and Stereoisomerism.
Matthias Eckhardt has included themes like Enzyme assay, Linagliptin and Enzyme inhibitor in his Xanthine study.
His most cited work include:
- Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. (361 citations)
- (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors. (268 citations)
- 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes. (239 citations)
What are the main themes of his work throughout his whole career to date?
Matthias Eckhardt focuses on Tautomer, Stereochemistry, Organic chemistry, Xanthine and Enantiomer.
His biological study spans a wide range of topics, including Diastereomer, Enzyme, Prodrug, Combinatorial chemistry and Inhibitory effect.
His Enzyme research is multidisciplinary, incorporating elements of Salt and Diabetes mellitus.
In his research, Medicinal chemistry is intimately related to Alkyl, which falls under the overarching field of Stereochemistry.
His Scientific method, Imidazole and Benzonitrile study in the realm of Organic chemistry connects with subjects such as Benzene derivatives.
His study in Xanthine is interdisciplinary in nature, drawing from both Substituent, Dipeptidylpeptidase iv and Dipeptidyl peptidase.
He most often published in these fields:
- Tautomer (42.15%)
- Stereochemistry (37.19%)
- Organic chemistry (26.45%)
What were the highlights of his more recent work (between 2010-2020)?
- Combinatorial chemistry (16.53%)
- Receptor (4.13%)
- Stereochemistry (37.19%)
In recent papers he was focusing on the following fields of study:
His main research concerns Combinatorial chemistry, Receptor, Stereochemistry, Free fatty acid receptor 1 and Tautomer.
His Scientific method research extends to the thematically linked field of Combinatorial chemistry.
His Stereochemistry study incorporates themes from Amino acid, Benzene and Enzyme.
His work in the fields of Dehydrogenase overlaps with other areas such as Biological activity.
His Tautomer research is multidisciplinary, incorporating perspectives in Prodrug, Enzyme assay, Inhibitory effect and Xanthine.
In his research on the topic of Xanthine, Medicinal chemistry is strongly related with Salt.
Between 2010 and 2020, his most popular works were:
- Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors. (361 citations)
- Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats. (42 citations)
- Sequential C-H Arylation and Enantioselective Hydrogenation Enables Ideal Asymmetric Entry to the Indenopiperidine Core of an 11β-HSD-1 Inhibitor. (19 citations)
In his most recent research, the most cited papers focused on:
- Organic chemistry
- Enzyme
- Diabetes mellitus
His primary areas of investigation include Receptor, Stereochemistry, Diabetes mellitus, Free fatty acid receptor 1 and Organic chemistry.
His research on Receptor often connects related topics like Combinatorial chemistry.
His studies deal with areas such as Dehydrogenase, Enzyme and Dyslipidemia as well as Stereochemistry.
His work carried out in the field of Diabetes mellitus brings together such families of science as Urinary system and Excretion.
His research ties Amino acid and Organic chemistry together.
His Salt study combines topics from a wide range of disciplines, such as Organic acid, Prodrug, Enantiomer and Tautomer.
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