Matthias Eckhardt

Overview

Best Publications

• Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.

  R. Grempler;L. Thomas;M. Eckhardt;F. Himmelsbach

  764
  Citations

• (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors.

  Leo Thomas;Matthias Eckhardt;Elke Langkopf;Moh Tadayyon

  458
  Citations

• 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.

  Matthias Eckhardt;Elke Langkopf;Michael Mark;Moh Tadayyon

  429
  Citations

• Molecular characterization of eukaryotic polysialyltransferase-1.

  Matthias Eckhardt;Martina Mühlenhoff;Andrea Bethe;Jaap Koopman

  419
  Citations

• Polysialic acid: three-dimensional structure, biosynthesis and function

  Martina Mühlenhoff;Matthias Eckhardt;Rita Gerardy-Schahn

  246
  Citations

• 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Michael Mark

  231
  Citations

• Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Peter Eickelmann;Frank Himmelsbach;Edward Leon Barsoumian

  224
  Citations

• The Role and Metabolism of Sulfatide in the Nervous System

  Unknown

  213
  Citations

• 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Michael Mark

  201
  Citations

• Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Frank Himmelsbach;Peter Eickelmann;Leo Thomas

  197
  Citations

• Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions

  Frank Himmelsbach;Michael Mark;Matthias Eckhardt;Elke Langkopf

  165
  Citations

• Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Frank Himmelsbach;Peter Eickelmann;Achim Sauer

  165
  Citations

• Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof

  Frank Himmelsbach;Matthias Eckhardt;Peter Eickelmann;Edward Leon Barsoumian

  164
  Citations

• Membrane topology of the mammalian CMP-sialic acid transporter.

  Matthias Eckhardt;Birgit Gotza;Rita Gerardy-Schahn

  162
  Citations

• Mutants of the CMP-sialic Acid Transporter Causing the Lec2 Phenotype

  Matthias Eckhardt;Birgit Gotza;Rita Gerardy-Schahn

  157
  Citations

• Ablation of Neuronal Ceramide Synthase 1 in Mice Decreases Ganglioside Levels and Expression of Myelin-associated Glycoprotein in Oligodendrocytes

  Christina Ginkel;Dieter Hartmann;Katharina vom Dorp;Armin Zlomuzica

  155
  Citations

• Autocatalytic polysialylation of polysialyltransferase-1.

  M Mühlenhoff;M Eckhardt;A Bethe;M Frosch

  154
  Citations

• 8-[3-amino-piperidin-1-yl]-xanthine, the production thereof and the use in the form of a ddp-iv inhibitor

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Mohammad Tadayyon

  145
  Citations

• COUPLING OF GLYCAL DERIVED THIOETHYL GLYCOSYL DONORS WITH GLYCAL ACCEPTORS. AN ADVANCE IN THE SCOPE OF THE GLYCAL ASSEMBLY

  Peter H. Seeberger;Matthias Eckhardt;Clare E. Gutteridge;Samuel J. Danishefsky

  143
  Citations

• Krystallinsk form av 1-klor-4-(B-D-glukopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloksy)-benzyl]-benzen, metode for fremstilling, samt anvendelse for fremstilling av medikamenter for behandling av sykdom

  Himmelsbach Frank;Eckhardt Matthias;Schmid Sandra;Schuehle Martin

  142
  Citations

• Novel 3-methyl-7-butinyl-xanthines, production thereof, and use thereof as medicaments

  Elke Langkopf;Matthias Eckhardt;Frank Himmelsbach;Mohammad Tadayyon

  129
  Citations

• Novel 2-(piperazin-1-yl)- and 2-([1,4]diazepan-1-yl)- imidazo[4,5-d]pyridazin-4-one, production and use thereof as medicament for the treatment of diabetes mellitus

  Frank Himmelsbach;Norbert Hauel;Elke Langkopf;Matthias Eckhardt

  124
  Citations

• Xanthine derivatives, production thereof and use thereof as medicines

  Matthias Eckhardt;Michael Mark;Frank Himmelsbach;Elke Langkopf

  123
  Citations

• Preparation and reactivity of chiral β-amido-alkylzinc iodides and related configurationally stable zinc organometallics

  Rajagopal Duddu;Matthias Eckhardt;Michael Furlong;H.Peter Knoess

  123
  Citations

• D-xylopyranosyl-phenyl-substituted cycles, medicaments containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Frank Himmelsbach;Peter Eickelmann;Leo Thomas

  112
  Citations

• Novel 8-(piperazine-1-yl)- and 8-( 1,4|diazepan-1-yl)-xanthine, the production and use thereof in the from of a drug

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Mohammad Tadayyon

  108
  Citations

• Bicyclic imidazole compounds, the production thereof and their use as medicaments

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Norbert Hauel

  107
  Citations