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Chris H. Senanayake

Chris H. Senanayake

D-Index & Metrics

Chemistry

D-Index
77
Citations
18670
World Ranking
4097
National Ranking
1296

Overview

Chris H. Senanayake is affiliated with TCG GreenChem Inc. in the United States and has contributed extensively to the field of chemistry, with a focus on organic chemistry. Their publication record includes 55 works in chemistry, with subfields spanning organic chemistry, materials chemistry, inorganic chemistry, molecular biology, and biomedical engineering.

Their research topics cover several specialized areas, including:

  • Asymmetric Hydrogenation and Catalysis
  • Chemical Synthesis and Analysis
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Innovative Microfluidic and Catalytic Techniques Innovation
  • Asymmetric Synthesis and Catalysis
  • Catalytic Cross-Coupling Reactions

Senanayake has published in a variety of scientific journals, with recurring presentations in these venues:

  • Organic Process Research & Development
  • The Journal of Organic Chemistry
  • The Cambridge Structural Database
  • Organic Letters
  • Journal of Liquid Chromatography & Related Technologies

Frequent collaborators include:

  • Bo Qu
  • Carl A. Busacca
  • Jinhua J. Song
  • Gopal Sirasani
  • Nizar Haddad

Recent publications illustrate a focus on synthetic methodology and chemical process development:

  • "Progress Toward a Large-Scale Synthesis of Molnupiravir (MK-4482, EIDD-2801) from Cytidine," 2021, ACS Omega
  • "Nickel-Catalyzed Cross-Electrophile Reductive Couplings of Neopentyl Bromides with Aryl Bromides," 2020, The Journal of Organic Chemistry
  • "Atom-Economical Cross-Coupling of Internal and Terminal Alkynes to Access 1,3-Enynes," 2021, Journal of the American Chemical Society
  • "Toward a Practical, Nonenzymatic Process for Investigational COVID-19 Antiviral Molnupiravir from Cytidine: Supply-Centered Synthesis," 2021, Organic Process Research & Development
  • "Recent advances and application of liquid chromatography in pharmaceutical industry," 2025, Journal of Liquid Chromatography & Related Technologies

Best Publications

  • Asymmetric Synthesis of Active Pharmaceutical Ingredients

    Vittorio Farina;Jonathan T Reeves;Chris H Senanayake;Jinhua J Song

  • The Growing Impact of Catalysis in the Pharmaceutical Industry

    Carl A. Busacca;Daniel R. Fandrick;Jinhua J. Song;Chris H. Senanayake

  • Overcoming barriers to green chemistry in the pharmaceutical industry – the Green Aspiration Level™ concept

    F. Roschangar;R. A. Sheldon;C. H. Senanayake

  • P-Chiral Phosphorus Ligands Based on a 2,3-Dihydrobenzo[d][1,3]oxaphosphole Motif for Asymmetric Catalysis

    Guangqing Xu;Chris H. Senanayake;Wenjun Tang

  • Efficient Syntheses of Korupensamines A, B and Michellamine B by Asymmetric Suzuki-Miyaura Coupling Reactions

    Guangqing Xu;Wenzhen Fu;Guodu Liu;Chris H. Senanayake

  • Derivatives of venlafaxine and methods of preparing and using the same

    Thomas P. Jerussi;Chrisantha H. Senanayake

  • A general and special catalyst for Suzuki-Miyaura coupling processes.

    Wenjun Tang;Andrew G. Capacci;Xudong Wei;Wenjie Li

  • Organometallic methods for the synthesis and functionalization of azaindoles

    Jinhua J. Song;Jonathan T. Reeves;Fabrice Gallou;Zhulin Tan

  • Activation of TMSCN by N-heterocyclic carbenes for facile cyanosilylation of carbonyl compounds.

    Jinhua J. Song;Fabrice Gallou;Jonathan T. Reeves;Zhulin Tan

  • A Superior Method for the Reduction of Secondary Phosphine Oxides

    Carl A Busacca;Jon C Lorenz;Nelu Grinberg;Nizar Haddad

  • Efficient Chiral Monophosphorus Ligands for Asymmetric Suzuki–Miyaura Coupling Reactions

    Wenjun Tang;Nitinchandra D. Patel;Guangqing Xu;Xiaobing Xu

  • Improved Fischer Indole Reaction for the Preparation of N,N-Dimethyltryptamines: Synthesis of L-695,894, a Potent 5-HT1D Receptor Agonist

    Cheng yi Chen;Chris H. Senanayake;Timothy J. Bill;Robert D. Larsen

  • Nickel-Catalyzed Esterification of Aliphatic Amides.

    Liana Hie;Emma L. Baker;Sarah M. Anthony;Jean-Nicolas Desrosiers

  • The First Regioselective Palladium-Catalyzed Indolization of 2-Bromo- or 2-Chloroanilines with Internal Alkynes: A New Approach to 2,3-Disubstituted Indoles

    Ming Shen;Guisheng Li;Bruce Z. Lu;Azad Hossain

  • N-Heterocyclic Carbene Catalyzed Trifluoromethylation of Carbonyl Compounds

    Jinhua J. Song;Zhulin Tan;Jonathan T. Reeves;Fabrice Gallou

  • Efficient asymmetric synthesis of P-chiral phosphine oxides via properly designed and activated benzoxazaphosphinine-2-oxide agents

    Zhengxu S Han;Navneet Goyal;Melissa A Herbage;Joshua D Sieber

  • Novel, tunable, and efficient chiral bisdihydrobenzooxaphosphole ligands for asymmetric hydrogenation.

    Wenjun Tang;Bo Qu;Andrew G. Capacci;Sonia Rodriguez

  • A practical mild, one-pot, regiospecific synthesis of 2,3-disubstituted indoles via consecutive Sonogashira and Cacchi reactions.

    Bruce Z. Lu;Wenyi Zhao;Han-Xun Wei;Marine Dufour

  • The reaction of Grignard reagents with Bunte salts: a thiol-free synthesis of sulfides.

    Jonathan T. Reeves;Kaddy Camara;Zhengxu S. Han;Yibo Xu

  • RCM macrocyclization made practical: an efficient synthesis of HCV protease inhibitor BILN 2061.

    Chutian Shu;Xingzhong Zeng;Ming-Hong Hao;Xudong Wei

  • The behavior of indene oxide in the ritter reaction: A simple route to cis-aminoindanol

    Chris H. Senanayake;F.Edward Roberts;Lisa M. DiMichele;Kenneth M. Ryan

Frequent Co-Authors

Wenjun Tang
Wenjun Tang Chinese Academy of Sciences
Paul J. Reider
Paul J. Reider Princeton University
Fabrice Gallou
Fabrice Gallou Novartis (Switzerland)
Marisa C. Kozlowski
Marisa C. Kozlowski University of Pennsylvania
Matthias Eckhardt
Matthias Eckhardt Boehringer Ingelheim (Germany)
Frank Himmelsbach
Frank Himmelsbach Boehringer Ingelheim (Germany)
Robert A. Reamer
Robert A. Reamer MSD (United States)
Peter Wipf
Peter Wipf University of Pittsburgh
Herbert Nar
Herbert Nar Boehringer Ingelheim (Germany)
Ian W. Davies
Ian W. Davies Princeton University

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