Frank Himmelsbach

Overview

Best Publications

• BIBW2992, an irreversible EGFR/HER2 inhibitor highly effective in preclinical lung cancer models.

  D Li;L Ambrogio;L Ambrogio;T Shimamura;S Kubo

  1703
  Citations

• Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker.

  Flavio Solca;Goeran Dahl;Andreas Zoephel;Gerd Bader

  1112
  Citations

• Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitors.

  R. Grempler;L. Thomas;M. Eckhardt;F. Himmelsbach

  764
  Citations

• (R)-8-(3-amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors.

  Leo Thomas;Matthias Eckhardt;Elke Langkopf;Moh Tadayyon

  458
  Citations

• 8-(3-(R)-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes.

  Matthias Eckhardt;Elke Langkopf;Michael Mark;Moh Tadayyon

  429
  Citations

• The p-nitrophenylethyl (NPE) group: A versatile new blocking group for phosphate and aglycone protection in nucleosides and nucleotides

  Frank Himmelsbach;Bernd S. Schulz;Thomas Trichtinger;Ramamurthy Charubala

  291
  Citations

• 8-[3-amino-piperidin-1-yl]-xanthines, the production thereof and the use of the same as medicaments

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Michael Mark

  231
  Citations

• Glucopyranosyl-substituted phenyl derivatives, medicaments containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Peter Eickelmann;Frank Himmelsbach;Edward Leon Barsoumian

  224
  Citations

• 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Michael Mark

  201
  Citations

• Glucopyranosyl-substituted benzyl-benzene derivatives, medicaments containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Frank Himmelsbach;Peter Eickelmann;Leo Thomas

  197
  Citations

• Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions

  Frank Himmelsbach;Michael Mark;Matthias Eckhardt;Elke Langkopf

  165
  Citations

• Glucopyranosyl-substituted benzonitrile derivatives, pharmaceutical compositions containing such compounds, their use and process for their manufacture

  Matthias Eckhardt;Frank Himmelsbach;Peter Eickelmann;Achim Sauer

  165
  Citations

• Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof

  Frank Himmelsbach;Matthias Eckhardt;Peter Eickelmann;Edward Leon Barsoumian

  164
  Citations

• 5-membered heterocyclic compounds, processes for preparing them and pharmaceutical compositions containing these compounds

  Volkhard Austel;Helmut Pieper;Frank Himmelsbach;Guenter Linz

  163
  Citations

• 8-[3-amino-piperidin-1-yl]-xanthine, the production thereof and the use in the form of a ddp-iv inhibitor

  Frank Himmelsbach;Elke Langkopf;Matthias Eckhardt;Mohammad Tadayyon

  145
  Citations

• Uses of DPP-IV inhibitors

  Klaus Dugi;Frank Himmelsbach;Michael Mark

  144
  Citations

• Krystallinsk form av 1-klor-4-(B-D-glukopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloksy)-benzyl]-benzen, metode for fremstilling, samt anvendelse for fremstilling av medikamenter for behandling av sykdom

  Himmelsbach Frank;Eckhardt Matthias;Schmid Sandra;Schuehle Martin

  142
  Citations

• Bicyclic heterocycles, medicaments containing these compounds, their use and methods for the production thereof

  Frank Himmelsbach;Elke Langkopf;Birgit Jung;Stefan Blech

  132
  Citations

• Novel 3-methyl-7-butinyl-xanthines, production thereof, and use thereof as medicaments

  Elke Langkopf;Matthias Eckhardt;Frank Himmelsbach;Mohammad Tadayyon

  129
  Citations

• Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them

  Frank Himmelsbach;Elke Langkopf;Thomas Metz;Flavio Solca

  128
  Citations