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Biology and Biochemistry
China
2023

D-Index & Metrics

Chemistry

D-Index
106
Citations
58994
World Ranking
930
National Ranking
167

Biology and Biochemistry

D-Index
108
Citations
59038
World Ranking
1031
National Ranking
20

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in China Leader Award

Overview

Hualiang Jiang was affiliated with the Chinese Academy of Sciences in China. Their research primarily focused on the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Within these broad areas, Jiang contributed substantially to Molecular Biology, Infectious Diseases, Computational Theory and Mathematics, Cellular and Molecular Neuroscience, and Immunology.

The scientist's work covered diverse topics, including:

  • Computational Drug Discovery Methods
  • Receptor Mechanisms and Signaling
  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • Protein Degradation and Inhibitors
  • Protein Structure and Dynamics
  • Machine Learning in Materials Science

Jiang was a frequent contributor to several key scientific journals, with multiple publications appearing in:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Medicinal Chemistry
  • Nature Communications
  • Acta Pharmacologica Sinica
  • Science China Life Sciences

Among recent papers that Jiang was associated with are:

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors, 2020, Nature
  • Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, 2020, Science
  • Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir, 2020, Science
  • TransformerCPI: improving compound-protein interaction prediction by sequence-based deep learning with self-attention mechanism and label reversal experiments, 2020, Bioinformatics
  • Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody, 2022, Science

They collaborated frequently with a number of researchers, including:

  • Mingyue Zheng
  • Kaixian Chen
  • H. Eric Xu
  • Yi Jiang
  • Cheng Luo

Their research involved a combination of experimental and computational approaches. Jiang's work contributed to understanding molecular mechanisms relevant to infectious diseases, especially concerning SARS-CoV-2 and COVID-19. This included studies on viral proteins, antiviral drug candidates, and protein interactions informed by machine learning techniques.

Best Publications

  • Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

    Zhenming Jin;Zhenming Jin;Xiaoyu Du;Yechun Xu;Yongqiang Deng

  • Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.

    Wenhao Dai;Wenhao Dai;Bing Zhang;Xia Ming Jiang;Haixia Su

  • Structural basis for inhibition of the RNA-dependent RNA polymerase from SARS-CoV-2 by remdesivir.

    Wanchao Yin;Wanchao Yin;Chunyou Mao;Xiaodong Luan;Xiaodong Luan;Dan Dan Shen

  • Predicting protein-protein interactions based only on sequences information.

    Juwen Shen;Jian Zhang;Xiaomin Luo;Weiliang Zhu

  • PharmMapper server: a web server for potential drug target identification using pharmacophore mapping approach

    Xiaofeng Liu;Sisheng Ouyang;Biao Yu;Yabo Liu

  • Pushing the Boundaries of Molecular Representation for Drug Discovery with the Graph Attention Mechanism.

    Zhaoping Xiong;Zhaoping Xiong;Dingyan Wang;Xiaohong Liu;Xiaohong Liu;Feisheng Zhong

  • Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

    Sergio E. Alvarez;Kuzhuvelil B. Harikumar;Nitai C. Hait;Jeremy Allegood

  • Structure of the CCR5 Chemokine Receptor–HIV Entry Inhibitor Maraviroc Complex

    Qiuxiang Tan;Ya Zhu;Jian Li;Zhuxi Chen

  • Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia.

    Yue Huang;Rui Su;Yue Sheng;Lei Dong;Lei Dong

  • Halogen bonding--a novel interaction for rational drug design?

    Yunxiang Lu;Ting Shi;Yong Wang;Huaiyu Yang

  • Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser

    Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He

  • Molecular Mimicry Regulates ABA Signaling by SnRK2 Kinases and PP2C Phosphatases

    Fen Fen Soon;Fen Fen Soon;Ley Moy Ng;Ley Moy Ng;X. Edward Zhou;Graham M. West

  • Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

    Yue Huang;Jingli Yan;Qi Li;Jiafei Li

  • Structural Basis for Molecular Recognition at Serotonin Receptors

    Chong Wang;Yi Jiang;Yi Jiang;Jinming Ma;Jinming Ma;Huixian Wu

  • TarFisDock: a web server for identifying drug targets with docking approach

    Honglin Li;Zhenting Gao;Ling Kang;Hailei Zhang

  • TransformerCPI: improving compound-protein interaction prediction by sequence-based deep learning with self-attention mechanism and label reversal experiments.

    Lifan Chen;Xiaoqin Tan;Dingyan Wang;Feisheng Zhong

  • Structures of the Omicron Spike trimer with ACE2 and an anti-Omicron antibody

    Unknown

  • Structure of the human P2Y12 receptor in complex with an antithrombotic drug

    Kaihua Zhang;Jin Zhang;Zhan-Guo Gao;Dandan Zhang

  • Development of Cell-Active N6-Methyladenosine RNA Demethylase FTO Inhibitor

    Baoen Chen;Fei Ye;Lu Yu;Guifang Jia

  • Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients.

    Hai xia Su;Sheng Yao;Wen feng Zhao;Min jun Li

  • Chemoprevention by lipoxygenase and leukotriene pathway inhibitors of vinyl carbamate-induced lung tumors in mice.

    Chul Ho Jeong;Ann M. Bode;Angelo Pugliese;Yong Yeon Cho

  • Computational drug discovery

    Si-sheng Ou-Yang;Jun-yan Lu;Xiang-qian Kong;Zhong-jie Liang

Frequent Co-Authors

Kaixian Chen
Kaixian Chen Chinese Academy of Sciences
Hong Liu
Hong Liu Shandong University
Xu Shen
Xu Shen Nanjing University of Chinese Medicine
Cheng Luo
Cheng Luo Chinese Academy of Sciences
Xiaomin Luo
Xiaomin Luo Chinese Academy of Sciences
Weiliang Zhu
Weiliang Zhu Chinese Academy of Sciences
Mingyue Zheng
Mingyue Zheng Chinese Academy of Sciences
Yu Zhou
Yu Zhou Chinese Academy of Sciences
Deju Ye
Deju Ye Nanjing University
Yun Tang
Yun Tang East China University of Science and Technology

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