His primary areas of investigation include Arrestin, Arrestin beta 2, Arrestin beta 1, Cell biology and Rhodopsin. His Arrestin research integrates issues from Biophysics and Phosphorylation. In his research, Rhodopsin-like receptors, Protein kinase A, Agonist and Intrinsic activity is intimately related to G protein, which falls under the overarching field of Arrestin beta 2.
His Cell biology research includes elements of Endocytosis and Clathrin. He combines subjects such as Rhodopsin kinase, Visual phototransduction and Binding selectivity with his study of Rhodopsin. His Beta-Arrestins study in the realm of G protein-coupled receptor interacts with subjects such as Beta-2 adrenergic receptor.
His primary areas of study are Arrestin, Cell biology, G protein-coupled receptor, Rhodopsin and Receptor. Vsevolod V. Gurevich has researched Arrestin in several fields, including Biophysics and Phosphorylation. Vsevolod V. Gurevich interconnects Internalization and Clathrin in the investigation of issues within Cell biology.
His G protein-coupled receptor research is multidisciplinary, relying on both Mutation, Heterotrimeric G protein, G protein and Protein–protein interaction. His research in Rhodopsin intersects with topics in Wild type, Mutant and Visual phototransduction. His work deals with themes such as Endocrinology and Function, which intersect with Receptor.
Vsevolod V. Gurevich focuses on Arrestin, Cell biology, G protein-coupled receptor, Receptor and Biophysics. His studies in Arrestin integrate themes in fields like Mutant, Programmed cell death, Phosphorylation and Protein–protein interaction. His Cell biology research includes themes of Parkin and Mutation.
Vsevolod V. Gurevich has included themes like Homologous desensitization, Cell signaling and G protein in his G protein-coupled receptor study. His Receptor study combines topics from a wide range of disciplines, such as Amino acid, Cell, Blood sugar and Endocrinology, Insulin. His work carried out in the field of Biophysics brings together such families of science as Rhodopsin, Nuclear magnetic resonance spectroscopy and Transmembrane domain.
His main research concerns Arrestin, G protein-coupled receptor, Cell biology, Phosphorylation and Receptor. The Arrestin study combines topics in areas such as Extracellular, Biophysics, Neuropeptide Y receptor and Binding site. Vsevolod V. Gurevich has researched G protein-coupled receptor in several fields, including Protein structure, Mutant and G protein.
His Signal transduction study, which is part of a larger body of work in Cell biology, is frequently linked to Loop, bridging the gap between disciplines. His work carried out in the field of Phosphorylation brings together such families of science as Cell signaling, Kinase and Scaffold protein. In the subject of general Receptor, his work in Vasopressin receptor is often linked to Parathyroid Hormone Receptor 1, thereby combining diverse domains of study.
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Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor.
Oscar B. Goodman;Jason G. Krupnick;Francesca Santini;Vsevolod V. Gurevich;Vsevolod V. Gurevich.
Calmodulin kinase II inhibition protects against structural heart disease
Rong Zhang;Michelle S.C. Khoo;Yuejin Wu;Yingbo Yang.
Nature Medicine (2005)
A Model for Arrestin’s Regulation: The 2.8 Å Crystal Structure of Visual Arrestin
Joel A. Hirsch;Carsten Schubert;Vsevolod V. Gurevich;Paul B. Sigler;Paul B. Sigler.
Arrestin Interactions with G Protein-coupled Receptors DIRECT BINDING STUDIES OF WILD TYPE AND MUTANT ARRESTINS WITH RHODOPSIN, β2-ADRENERGIC, AND m2 MUSCARINIC CHOLINERGIC RECEPTORS
Vsevolod V. Gurevich;Stephane B. Dion;James J. Onorato;Judith Ptasienski.
Journal of Biological Chemistry (1995)
Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser
Yanyong Kang;X. Edward Zhou;Xiang Gao;Yuanzheng He.
The structural basis of arrestin-mediated regulation of G-protein-coupled receptors
Vsevolod V. Gurevich;Eugenia V. Gurevich.
Pharmacology & Therapeutics (2006)
G protein-coupled receptor kinases: more than just kinases and not only for GPCRs.
Eugenia V. Gurevich;John J.G. Tesmer;Arcady Mushegian;Vsevolod V. Gurevich.
Pharmacology & Therapeutics (2012)
Crystal structure of beta-arrestin at 1.9 A: possible mechanism of receptor binding and membrane Translocation.
May Han;Vsevolod V Gurevich;Sergey A Vishnivetskiy;Paul B Sigler;Paul B Sigler.
The molecular acrobatics of arrestin activation.
Vsevolod V Gurevich;Eugenia V Gurevich.
Trends in Pharmacological Sciences (2004)
Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin.
V V Gurevich;J L Benovic.
Journal of Biological Chemistry (1993)
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