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Stephen S. G. Ferguson

Stephen S. G. Ferguson

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Biology and Biochemistry
Canada
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
87
Citations
27968
World Ranking
2826
National Ranking
88

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Canada Leader Award

Overview

Stephen S. G. Ferguson is affiliated with the University of Ottawa in Canada and conducts research primarily in the fields of neuroscience, biochemistry, genetics, molecular biology, and medicine. Their work spans several key subfields including cellular and molecular neuroscience, molecular biology, physiology, neurology, and complementary and alternative medicine.

Their primary research topics focus on neuroscience and neuropharmacology, with a significant emphasis on Alzheimer's disease research and treatments. Additional areas of study include genetic neurodegenerative diseases, receptor mechanisms and signaling, mitochondrial function and pathology, neuroinflammation and neurodegeneration mechanisms, and memory and neural mechanisms.

Stephen S. G. Ferguson has published numerous papers across various respected scientific venues. Notable recent papers include:

  1. Aβ oligomers induce pathophysiological mGluR5 signaling in Alzheimer's disease model mice in a sex-selective manner, 2020, Science Signaling
  2. Noncanonical Metabotropic Glutamate Receptor 5 Signaling in Alzheimer's Disease, 2021, The Annual Review of Pharmacology and Toxicology
  3. mGluR5 Contribution to Neuropathology in Alzheimer Mice Is Disease Stage-Dependent, 2020, ACS Pharmacology & Translational Science
  4. Targeting mGluR2/3 for treatment of neurodegenerative and neuropsychiatric diseases, 2022, Pharmacology & Therapeutics
  5. mGluR5 regulates REST/NRSF signaling through N-cadherin/β-catenin complex in Huntington's disease, 2020, Molecular Brain

Their frequent coauthors include:

  • Khaled S. Abd-Elrahman
  • Tash-Lynn L. Colson
  • Karim Ibrahim
  • Awatif B. Albaker
  • Alison Hamilton

Stephen S. G. Ferguson has published extensively in journals such as:

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Brain
  • Molecular Pharmacology
  • The FASEB Journal
  • Science Signaling

Their research contributions cover detailed mechanisms related to receptor signaling pathways, neurodegenerative disease progression, and cellular pathology associated with aging and neurological disorders. The investigation into metabotropic glutamate receptors, especially mGluR5, underlies much of their work relevant to Alzheimer's and Huntington's diseases.

Best Publications

  • Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling

    Stephen S. G. Ferguson

  • Beta-arrestin-dependent formation of beta2 adrenergic receptor-Src protein kinase complexes.

    L. M. Luttrell;S. S. G. Ferguson;Y. Daaka;W. E. Miller

  • Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

    Stephen S. G. Ferguson;William E. Downey;Anne-Marie Colapietro;Larry S. Barak

  • The β2-adrenergic receptor/βarrestin complex recruits the clathrin adaptor AP-2 during endocytosis

    Stéphane A. Laporte;Robert H. Oakley;Jie Zhang;Jason A. Holt

  • Essential Role for G Protein-coupled Receptor Endocytosis in the Activation of Mitogen-activated Protein Kinase

    Yehia Daaka;Louis M. Luttrell;Seungkirl Ahn;Gregory J. Della Rocca

  • Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness

    Jie Zhang;Stephen S. G. Ferguson;Stephen S. G. Ferguson;Larry S. Barak;Sobha R. Bodduluri

  • Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

    Jie Zhang;Stephen S.G. Ferguson;Larry S. Barak;Luc Ménard

  • A β-Arrestin/Green Fluorescent Protein Biosensor for Detecting G Protein-coupled Receptor Activation

    Larry S. Barak;Stephen S.G. Ferguson;Jie Zhang;Marc G. Caron

  • G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins.

    S. S. G. Ferguson;L. S. Barak;J. Zhang;M. G. Caron

  • Integration of dosimetry, exposure, and high-throughput screening data in chemical toxicity assessment.

    Barbara A. Wetmore;John F. Wambaugh;Stephen S. Ferguson;Mark A. Sochaski

  • Regulation of GPCR activity, trafficking and localization by GPCR‐interacting proteins

    Ana C Magalhaes;Ana C Magalhaes;Henry Dunn;Henry Dunn;Stephen Sg Ferguson;Stephen Sg Ferguson

  • A central role for beta-arrestins and clathrin-coated vesicle-mediated endocytosis in beta2-adrenergic receptor resensitization. Differential regulation of receptor resensitization in two distinct cell types.

    Jie Zhang;Larry S. Barak;Katharine E. Winkler;Marc G. Caron

  • Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease

    Craig D. Fisher;Andrew J. Lickteig;Lisa M. Augustine;James Ranger-Moore

  • Molecular mechanism of desensitization of the chemokine receptor CCR‐5: receptor signaling and internalization are dissociable from its role as an HIV‐1 co‐receptor

    Ichiro Aramori;Jie Zhang;Stephen S.G. Ferguson;Paul D. Bieniasz;Paul D. Bieniasz

  • Cellular trafficking of G protein-coupled receptor/beta-arrestin endocytic complexes.

    Jie Zhang;Larry S. Barak;Pieter H. Anborgh;Stephane A. Laporte

  • Internal Trafficking and Surface Mobility of a Functionally Intact β2-Adrenergic Receptor-Green Fluorescent Protein Conjugate

    Larry S. Barak;Stephen S. G. Ferguson;Jie Zhang;Christopher Martenson

  • Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

    Clifford R. Elcombe;Richard C. Peffer;Douglas C. Wolf;Jason Bailey

  • Molecular mechanisms of G protein-coupled receptor desensitization and resensitization.

    S. S. G. Ferguson;Jie Zhang;L. S. Barak;M. G. Caron

  • HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor.

    Paul D. Bieniasz;Robert A. Fridell;Ichiro Aramori;Stephen S.G. Ferguson

  • Incorporating Human Dosimetry and Exposure into High-Throughput In Vitro Toxicity Screening

    Daniel M. Rotroff;Daniel M. Rotroff;Barbara A. Wetmore;David J. Dix;Stephen S. Ferguson

Frequent Co-Authors

Marc G. Caron
Marc G. Caron Duke University
Larry S. Barak
Larry S. Barak Duke University
David J. Kelvin
David J. Kelvin Dalhousie University
Vania F. Prado
Vania F. Prado University of Western Ontario
Marco A. M. Prado
Marco A. M. Prado University of Western Ontario
Robert J. Lefkowitz
Robert J. Lefkowitz Duke University
Joyce A. Goldstein
Joyce A. Goldstein National Institutes of Health
Louis M. Luttrell
Louis M. Luttrell Medical University of South Carolina
Michael O. Poulter
Michael O. Poulter University of Western Ontario
Bryan R. Cullen
Bryan R. Cullen Duke University

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