World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
116
Citations
45464
World Ranking
754
National Ranking
475

Medicine

D-Index
116
Citations
45558
World Ranking
4384
National Ranking
2396

Overview

Nigel W. Bunnett is affiliated with New York University in the United States. Their research spans a broad range of topics within the fields of medicine, biochemistry, genetics and molecular biology, and neuroscience. The scientist has contributed to understanding cellular and molecular neuroscience, physiology, molecular biology, surgery, and hematology.

Significant research areas include pain mechanisms and treatments, neuropeptides and animal physiology, receptor mechanisms and signaling, blood coagulation and thrombosis mechanisms, pharmacological receptor mechanisms and effects, ion channels and receptors, and axon guidance and neuronal signaling.

  • Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice (2022, Nature Communications)
  • Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain (2020, Proceedings of the National Academy of Sciences)
  • Protease-activated receptors in health and disease (2022, Physiological Reviews)
  • Nanotechnology for pain management: Current and future therapeutic interventions (2021, Nano Today)
  • Peripheral Nerve Resident Macrophages and Schwann Cells Mediate Cancer-Induced Pain (2021, Cancer Research)

Frequent co-authors in their publications include Brian L. Schmidt, Nestor N. Jiménez-Vargas, Stephen Vanner, Dane D. Jensen, and Rocco Latorre.

The scientist has published extensively in a range of venues including Gastroenterology, bioRxiv (Cold Spring Harbor Laboratory), Journal of the Canadian Association of Gastroenterology, Proceedings of the National Academy of Sciences, and Pain. Among these, Gastroenterology and bioRxiv are notable for hosting multiple contributions.

Best Publications

  • Activated mast cells in proximity to colonic nerves correlate with abdominal pain in irritable bowel syndrome.

    Giovanni Barbara;Vincenzo Stanghellini;Roberto De Giorgio;Cesare Cremon

  • Protease-Activated Receptors: Contribution to Physiology and Disease

    Valeria S. Ossovskaya;Nigel W. Bunnett

  • Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.

    M Steinhoff;N Vergnolle;S H Young;M Tognetto

  • beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2.

    K.A. DeFea;J. Zalevsky;M.S. Thoma;O. Déry

  • Proteinase-activated receptors: novel mechanisms of signaling by serine proteases

    Olivier Déry;Carlos U. Corvera;Martin Steinhoff;Nigel W. Bunnett

  • Mast Cell-Dependent Excitation of Visceral-Nociceptive Sensory Neurons in Irritable Bowel Syndrome

    Giovanni Barbara;Bingxian Wang;Vincenzo Stanghellini;Roberto de Giorgio

  • 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

    Marcello Trevisani;Jan Siemens;Serena Materazzi;Diana M. Bautista

  • Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

    Dirk Roosterman;Tobias Goerge;Stefan W. Schneider;Nigel W. Bunnett

  • Role for protease activity in visceral pain in irritable bowel syndrome.

    Nicolas Cenac;Christopher N. Andrews;Marinella Holzhausen;Kevin Chapman

  • REGULATORY MECHANISMS THAT MODULATE SIGNALLING BY G-PROTEIN-COUPLED RECEPTORS

    Stephan K. Böhm;Eileen F. Grady;Nigel W. Bunnett

  • T cell gelatinases mediate basement membrane transmigration in vitro.

    D Leppert;E Waubant;R Galardy;N W Bunnett

  • Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease

    Martin S Steinhoff;Bengt von Mentzer;Pierangelo Geppetti;Charalabos Pothoulakis

  • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

    Stephan K. Böhm;Wuyi Kong;Dieter Brömme;Steven P. Smeekens

  • Proteinase-activated receptor-2 and hyperalgesia: A novel pain pathway.

    N. Vergnolle;N.W. Bunnett;K.A. Sharkey;V. Brussee

  • Endocytosis of Activated TrkA: Evidence that Nerve Growth Factor Induces Formation of Signaling Endosomes

    Mark L. Grimes;Jie Zhou;Eric C. Beattie;Eric C. Yuen

  • Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems.

    T. Scholzen;C. A. Armstrong;C. A. Armstrong;N. W. Bunnett;T. A. Luger

  • The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex

    K. A. DeFea;Z. D. Vaughn;E. M. O'Bryan;D. Nishijima

  • Protease-Activated Receptor 2 Sensitizes the Capsaicin Receptor Transient Receptor Potential Vanilloid Receptor 1 to Induce Hyperalgesia

    Silvia Amadesi;Jingjiang Nie;Nathalie Vergnolle;Graeme S. Cottrell

  • Cigarette smoke–induced neurogenic inflammation is mediated by α,β-unsaturated aldehydes and the TRPA1 receptor in rodents

    Eunice Andrè;Barbara Campi;Serena Materazzi;Marcello Trevisani

  • Protease-activated receptors in inflammation, neuronal signaling and pain.

    Nathalie Vergnolle;John L Wallace;Nigel W Bunnett;Morley D Hollenberg

Frequent Co-Authors

Eileen F. Grady
Eileen F. Grady University of California, San Francisco
Martin Steinhoff
Martin Steinhoff Hamad Medical Corporation
Pierangelo Geppetti
Pierangelo Geppetti University of Florence
John C. Ansel
John C. Ansel Northwestern University
Donald G. Payan
Donald G. Payan Sunesis (United States)
Meritxell Canals
Meritxell Canals University of Nottingham
Morley D. Hollenberg
Morley D. Hollenberg University of Calgary
Peter McIntyre
Peter McIntyre University of Otago
Stuart M. Brierley
Stuart M. Brierley Flinders University

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