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D-Index & Metrics

Biology and Biochemistry

D-Index
79
Citations
19935
World Ranking
4375
National Ranking
2131

Overview

Donald G. Payan is affiliated with Sunesis in the United States. Their research focuses primarily on the fields of Medicine, Biochemistry, Genetics and Molecular Biology, and Immunology and Microbiology. These broad fields encompass subfields including Immunology, Molecular Biology, Surgery, Cancer Research, and Oncology.

The main topics covered in their research output include Metabolism, Diabetes, and Cancer, Pancreatic Function and Diabetes, Immune Response and Inflammation, NF-κB Signaling Pathways, Cytokine Signaling Pathways and Interactions, Diabetes Treatment and Management, and Interferon and Immune Responses.

Frequent coauthors who have collaborated with Donald G. Payan include:

  • Gary Park
  • Rajinder Singh
  • Yan Chen
  • Vanessa Taylor
  • Esteban S. Masuda

Key publication venues where Payan's work has appeared are:

  • ACS Medicinal Chemistry Letters
  • Journal of Medicinal Chemistry
  • Bioorganic & Medicinal Chemistry Letters
  • Bioorganic & Medicinal Chemistry

Recent papers authored by or featuring Donald G. Payan include:

  • Discovery of 5-Aryl-2,4-diaminopyrimidine Compounds as Potent and Selective IRAK4 Inhibitors (2022), published in ACS Medicinal Chemistry Letters
  • Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators (2023), Journal of Medicinal Chemistry
  • Optimization of Pyrimidine Compounds as Potent JAK1 Inhibitors and the Discovery of R507 as a Clinical Candidate (2022), ACS Medicinal Chemistry Letters
  • Bicyclic Pyrimidine Compounds as Potent IRAK4 Inhibitors (2022), Bioorganic & Medicinal Chemistry Letters
  • Structure Activity Relationships Leading to the Identification of the Indirect Activator of AMPK, R419 (2022), Bioorganic & Medicinal Chemistry

Their research contributions address key molecular targets such as IRAK4 and JAK1, exploring the development of inhibitors and activators relevant to immune response regulation and metabolic processes. The investigators' focus on cytokine signaling and NF-κB pathways connects the molecular mechanisms to broader immunological and inflammatory outcomes.

Payan's work intersects areas of metabolism, diabetes, and cancer, contributing to understanding pancreatic function and diabetes management. The research often combines medicinal chemistry approaches with pharmacokinetic and safety profiling to advance potential therapeutic candidates.

Best Publications

  • R428, a Selective Small Molecule Inhibitor of Axl Kinase, Blocks Tumor Spread and Prolongs Survival in Models of Metastatic Breast Cancer

    Sacha J Holland;Alison Pan;Christian Franci;Yuanming Hu

  • R406, an Orally Available Spleen Tyrosine Kinase Inhibitor Blocks Fc Receptor Signaling and Reduces Immune Complex-Mediated Inflammation

    Sylvia Braselmann;Vanessa Taylor;Haoran Zhao;Su Wang

  • Molecular cloning, expression and potential functions of the human proteinase-activated receptor-2

    Stephan K. Böhm;Wuyi Kong;Dieter Brömme;Steven P. Smeekens

  • Substance P selectively activates TNF-alpha gene expression in murine mast cells.

    John C. Ansel;Jeffrey R. Brown;Donald G. Payan;Melissa A. Brown

  • Structure and expression of a rat agrin.

    Fabio Rupp;Donald G. Payan;Catherine Magill-Solc;David M. Cowan

  • NEUROPEPTIDES AND INFLAMMATION: The Role of Substance P

    Donald G. Payan

  • Neutrophil rolling altered by inhibition of L-selectin shedding in vitro.

    B. Walcheck;J. Kahn;J. M. Fisher;B. B. Wang

  • Substance P recognition by a subset of human T lymphocytes.

    D G Payan;D R Brewster;A Missirian-Bastian;E J Goetzl

  • Luminal trypsin may regulate enterocytes through proteinase-activated receptor 2

    Wuyi Kong;Karen McConalogue;Lev M. Khitin;Morley D. Hollenberg

  • Mechanisms of Desensitization and Resensitization of Proteinase-activated Receptor-2

    Stephan K. Böhm;Lev M. Khitin;Eileen F. Grady;Gregory Aponte

  • Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.

    Carlos U. Corvera;Olivier Déry;K. McConalogue;Stephan K. Böhm

  • Detection of programmed cell death using fluorescence energy transfer

    Xiang Xu;Amy L.V. Gerard;Betty C.B. Huang;David C. Anderson

  • 2,4-pyrimidinediamine compounds and their uses

    Rajinder Singh;Ankush Argade;Donald G Payan;Susan Molineaux

  • Characterization of antibodies to the rat substance P (NK-1) receptor and to a chimeric substance P receptor expressed in mammalian cells

    SR Vigna;JJ Bowden;DM McDonald;J Fisher

  • Discovering patterns to extract protein--protein interactions from full texts

    Minlie Huang;Xiaoyan Zhu;Yu Hao;Donald G. Payan

  • Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

    Eileen F. Grady;Adella M. Garland;Patrick D. Gamp;Michelle Lovett

  • A new algorithm for the evaluation of shotgun peptide sequencing in proteomics: support vector machine classification of peptide MS/MS spectra and SEQUEST scores.

    D C Anderson;Weiqun Li;Donald G Payan;William Stafford Noble

  • Characterization of Antisera Specific to NK1, NK2, and NK3 Neurokinin Receptors and their Utilization to Localize Receptors in the Rat Gastrointestinal Tract

    Eileen F. Grady;Peter Baluk;Stephan Böhm;Patrick D. Gamp

  • Skin-Nervous System Interactions

    John C. Ansel;Alan H. Kaynard;Cheryl A. Armstrong;John Olerud

  • TNIK, a Novel Member of the Germinal Center Kinase Family That Activates the c-Jun N-terminal Kinase Pathway and Regulates the Cytoskeleton

    C. Alan Fu;Mary Shen;Betty C.B. Huang;Joe Lasaga

Frequent Co-Authors

Hui Li
Hui Li Wake Forest University
Nigel W. Bunnett
Nigel W. Bunnett New York University
Eileen F. Grady
Eileen F. Grady University of California, San Francisco
David L. Carroll
David L. Carroll Wake Forest University
Edward J. Goetzl
Edward J. Goetzl University of California, San Francisco
Garry P. Nolan
Garry P. Nolan Stanford University
John Bienenstock
John Bienenstock McMaster University
John C. Ansel
John C. Ansel Northwestern University
Dieter Brömme
Dieter Brömme University of British Columbia
Benoit Viollet
Benoit Viollet Institut Cochin

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