World's Best Scientists 2026 revealed!

D-Index & Metrics

Immunology

D-Index
46
Citations
7440
World Ranking
4631
National Ranking
2085

Overview

Bruce Walcheck is affiliated with the University of Minnesota in the United States and has contributed extensively to the fields of medicine, immunology, and microbiology. Their research focuses on areas including immunology, oncology, molecular biology, radiology, nuclear medicine, imaging, and infectious diseases.

The scientist's main research topics cover:

  • CAR-T cell therapy research
  • Immune Cell Function and Interaction
  • Monoclonal and Polyclonal Antibodies Research
  • T-cell and B-cell Immunology
  • CRISPR and Genetic Engineering
  • Advanced biosensing and bioanalysis techniques
  • Glycosylation and Glycoproteins Research

Frequent co-authors in their work include:

  • Jeffrey S. Miller
  • Bahram Valamehr
  • Ryan Bjordahl
  • Jianming Wu
  • Kristin M. Snyder

Bruce Walcheck has published multiple papers in notable academic venues, with repeated contributions in:

  • Blood
  • The Journal of Immunology
  • Frontiers in Immunology
  • Cancer Research
  • Regular and Young Investigator Award Abstracts

Some of their recent publications include:

  • "Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy" (2021, Cell stem cell)
  • "Engineering Anti-Tumor Monoclonal Antibodies and Fc Receptors to Enhance ADCC by Human NK Cells" (2021, Cancers)
  • "Dual antigen-targeted off-the-shelf NK cells show durable response and prevent antigen escape in lymphoma and leukemia" (2022, Blood)
  • "Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma" (2022, Nature Communications)
  • "FT576: Multi-Specific Off-the-Shelf CAR-NK Cell Therapy Engineered for Enhanced Persistence, Avoidance of Self-Fratricide and Optimized Mab Combination Therapy to Prevent Antigenic Escape and Elicit a Deep and Durable Response in Multiple Myeloma" (2020, Blood)

The research themes within these works emphasize natural killer (NK) cells, CAR-NK and CAR-T cell therapies, monoclonal antibodies, and immune response modulation, reflecting a significant focus on cellular immunotherapy against cancers such as lymphoma, leukemia, and multiple myeloma.

Best Publications

  • NK cell CD16 surface expression and function is regulated by a disintegrin and metalloprotease-17 (ADAM17)

    Rizwan Romee;Bree Foley;Todd R Lenvik;Yue Wang

  • Neutrophil-neutrophil interactions under hydrodynamic shear stress involve L-selectin and PSGL-1. A mechanism that amplifies initial leukocyte accumulation of P-selectin in vitro.

    Bruce Walcheck;Kevin L. Moore;Kevin L. Moore;Rodger P. McEver;Rodger P. McEver;Takashi Kei Kishimoto

  • Neutrophil rolling altered by inhibition of L-selectin shedding in vitro.

    B. Walcheck;J. Kahn;J. M. Fisher;B. B. Wang

  • Pluripotent stem cell-derived NK cells with high-affinity noncleavable CD16a mediate improved antitumor activity.

    Huang Zhu;Robert H. Blum;Ryan Bjordahl;Svetlana Gaidarova

  • Targeting natural killer cells to acute myeloid leukemia in vitro with a CD16 x 33 bispecific killer cell engager and ADAM17 inhibition

    Andres Wiernik;Bree Foley;Bin Zhang;Michael R. Verneris

  • Role of ADAM17 in the ectodomain shedding of TNF-α and its receptors by neutrophils and macrophages

    Jessica H. Bell;Amy H. Herrera;Ying Li;Bruce Walcheck

  • Rapid activation-independent shedding of leukocyte L-selectin induced by cross-linking of the surface antigen.

    Aiyappa Palecanda;Bruce Walcheck;D. Keith Bishop;Mark A. Jutila

  • A Genetically Engineered Primary Human Natural Killer Cell Platform for Cancer Immunotherapy

    Emily J. Pomeroy;John T. Hunzeker;Mitchell G. Kluesner;Walker S. Lahr

  • Regulation of mature ADAM17 by redox agents for L-selectin shedding.

    Yue Wang;Amy H. Herrera;Ying Li;Ying Li;Kiran K. Belani

  • ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding

    Ying Li;Jennifer Brazzell;Amy Herrera;Bruce Walcheck

  • Identification of an ADAM17 Cleavage Region in Human CD16 (FcγRIII) and the Engineering of a Non-Cleavable Version of the Receptor in NK Cells

    Yawu Jing;Zhenya Ni;Jianming Wu;Lee Ann Higgins

  • Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy

    Karrune V. Woan;Hansol Kim;Ryan Bjordahl;Zachary B. Davis

  • Lymphocyte function-associated antigen 1 is a receptor for Pasteurella haemolytica leukotoxin in bovine leukocytes.

    S. Jeyaseelan;S. L. Hsuan;Mathur S Kannan;Bruce Walcheck

  • Tumor-induced MDSC act via remote control to inhibit L-selectin-dependent adaptive immunity in lymph nodes.

    Amy W Ku;Jason B Muhitch;Colin A Powers;Michael G Diehl

  • ADAM17 cleaves CD16b (FcγRIIIb) in human neutrophils

    Yue Wang;Jianming Wu;Robert Newton;Nooshin S. Bahaie

  • Characterization of a functionally important and evolutionarily well-conserved epitope mapped to the short consensus repeats of E-selectin and L-selectin.

    Mark A. Jutila;Gayle Watts;Bruce Walcheck;Geoffrey S. Kansas

  • Bovine gamma/delta T cells bind E-selectin via a novel glycoprotein receptor: first characterization of a lymphocyte/E-selectin interaction in an animal model.

    Bruce Walcheck;Gayle Watts;Mark A. Jutila

  • Regulation of expression of major histocompatibility antigens by bovine macrophages infected with Mycobacterium avium subsp. paratuberculosis or Mycobacterium avium subsp. avium.

    Douglas J. Weiss;Oral A. Evanson;David J. McClenahan;Mitchell S. Abrahamsen

  • Role of ADAM17 as a regulatory checkpoint of CD16A in NK cells and as a potential target for cancer immunotherapy.

    Jianming Wu;Hemant K Mishra;Bruce Walcheck

  • Cell surface P- and E-selectin support shear-dependent rolling of bovine gamma/delta T cells.

    M A Jutila;R F Bargatze;S Kurk;R A Warnock

  • Evaluation of flow cytometric and automated methods for detection of activated platelets in dogs with inflammatory disease.

    Andreas Moritz;Bruce K. Walcheck;Douglas J. Weiss

  • ADAM17 deficiency by mature neutrophils has differential effects on L-selectin shedding

    Ying Li;Amy Herrera;Bruce Walcheck

Frequent Co-Authors

Jeffrey S. Miller
Jeffrey S. Miller University of Minnesota
Mark A. Jutila
Mark A. Jutila Montana State University
Thomas H. Lee
Thomas H. Lee Harvard University
Dan S. Kaufman
Dan S. Kaufman University of California, San Diego
Takashi Kei Kishimoto
Takashi Kei Kishimoto Selecta Biosciences (United States)
Ying Li
Ying Li Nanjing Agricultural University
Karl-Johan Malmberg
Karl-Johan Malmberg Oslo University Hospital
Rodger P. McEver
Rodger P. McEver Oklahoma Medical Research Foundation
Ricardo C. Chebel
Ricardo C. Chebel University of Florida
Brian A Crooker
Brian A Crooker University of Minnesota

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