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Konstantinos Konstantopoulos

Konstantinos Konstantopoulos

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
17136
World Ranking
5695
National Ranking
2699

Research.com Recognitions

  • 2010 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Konstantinos Konstantopoulos is affiliated with Johns Hopkins University in the United States. Their research spans multiple disciplines within the life sciences, with a focus on biochemistry, genetics, molecular biology, and medicine. The scientist's work prominently engages with topics in cell biology, molecular biology, oncology, physiology, and biomedical engineering.

The research topics covered by Konstantopoulos include:

  • Cellular Mechanics and Interactions
  • Microtubule and mitosis dynamics
  • Cancer Cells and Metastasis
  • Erythrocyte Function and Pathophysiology
  • 3D Printing in Biomedical Research
  • Hippo pathway signaling and YAP/TAZ
  • RNA Research and Splicing

Several recent publications illustrate the scope and impact of their research. These include:

  • Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial, 2021, The Lancet
  • Extracellular fluid viscosity enhances cell migration and cancer dissemination, 2022, Nature
  • A Procarcinogenic Colon Microbe Promotes Breast Tumorigenesis and Metastatic Progression and Concomitantly Activates Notch and β-Catenin Axes, 2021, Cancer Discovery
  • The fluid shear stress sensor TRPM7 regulates tumor cell intravasation, 2021, Science Advances
  • A microfluidic cell-migration assay for the prediction of progression-free survival and recurrence time of patients with glioblastoma, 2020, Nature Biomedical Engineering

Konstantopoulos frequently collaborates with a group of scientists including Sean X. Sun, Panagiotis Mistriotis, Kaustav Bera, Zhuoxu Ge, and Alexander Kiepas.

Their work has appeared commonly in publication venues such as bioRxiv (Cold Spring Harbor Laboratory), Science Advances, Cancer Research, Nature Communications, and Proceedings of the National Academy of Sciences.

In recognition of their contributions, Konstantopoulos was named a Fellow of the Indian National Academy of Engineering in 2010.

Best Publications

  • The physics of cancer: the role of physical interactions and mechanical forces in metastasis

    Denis Wirtz;Konstantinos Konstantopoulos;Peter C. Searson

  • Cancer cell motility: lessons from migration in confined spaces

    Colin D. Paul;Panagiotis Mistriotis;Konstantinos Konstantopoulos

  • Water Permeation Drives Tumor Cell Migration in Confined Microenvironments

    Kimberly M. Stroka;Hongyuan Jiang;Shih Hsun Chen;Ziqiu Tong

  • Effects of fluid dynamic forces on vascular cell adhesion.

    Konstantinos Konstantopoulos;Larry V. McIntire

  • Physical confinement alters tumor cell adhesion and migration phenotypes

    Eric M. Balzer;Ziqiu Tong;Colin D. Paul;Wei Chien Hung

  • Immobilized platelets support human colon carcinoma cell tethering, rolling, and firm adhesion under dynamic flow conditions

    Owen J. T. McCarty;Shaker A. Mousa;Paul F. Bray;Konstantinos Konstantopoulos;Konstantinos Konstantopoulos

  • A 3-D computational model predicts that cell deformation affects selectin-mediated leukocyte rolling.

    Sameer Jadhav;Charles D. Eggleton;Konstantinos Konstantopoulos

  • Cancer cells in transit: the vascular interactions of tumor cells.

    Konstantinos Konstantopoulos;Susan N. Thomas

  • Single-molecule analysis of cadherin-mediated cell-cell adhesion.

    Porntula Panorchan;Melissa S. Thompson;Kelly J. Davis;Yiider Tseng

  • Single molecule characterization of P-selectin/ligand binding.

    William Hanley;Owen McCarty;Sameer Jadhav;Yiider Tseng

  • Carcinoembryonic Antigen and CD44 Variant Isoforms Cooperate to Mediate Colon Carcinoma Cell Adhesion to E- and L-selectin in Shear Flow

    Susan N. Thomas;Fei Zhu;Ronald L. Schnaar;Christina S. Alves

  • Mesothelin Binding to CA125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation

    Shih Hsun Chen;Wei Chien Hung;Pu Wang;Colin Paul

  • Venous Levels of Shear Support Neutrophil-Platelet Adhesion and Neutrophil Aggregation in Blood via P-Selectin and β2-Integrin

    K Konstantopoulos;S Neelamegham;S Neelamegham;A R Burns;E Hentzen

  • Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses

    Carlos Pardo-Pastor;Fanny Rubio-Moscardo;Marina Vogel-González;Selma A. Serra

  • A physical sciences network characterization of non-tumorigenic and metastatic cells

    David B. Agus;Jenolyn F. Alexander;Wadih Arap;Shashanka Ashili

  • Significant improvement in the survival of patients with multiple myeloma presenting with severe renal impairment after the introduction of novel agents

    M.A. Dimopoulos;S. Delimpasi;E. Katodritou;A. Vassou

  • Chemotaxis of Cell Populations through Confined Spaces at Single-Cell Resolution

    Zi Qiu Tong;Eric M. Balzer;Matthew R. Dallas;Wei Chien Hung

  • Divergent responses of chondrocytes and endothelial cells to shear stress: Cross-talk among COX-2, the phase 2 response, and apoptosis

    Zachary R. Healy;Norman H. Lee;Xiangqun Gao;Mary B. Goldring

  • Confinement Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways

    Wei Chien Hung;Jessica R. Yang;Christopher L. Yankaskas;Bin Sheng Wong

  • Immobilized platelets support human colon carcinoma cell tethering, rolling and firm adhesion under dynamic flow conditions

    Owen McCarty;Konstantinos Konstantopoulos

Frequent Co-Authors

Denis Wirtz
Denis Wirtz Johns Hopkins University
Evangelos Terpos
Evangelos Terpos National and Kapodistrian University of Athens
Owen J. T. McCarty
Owen J. T. McCarty Oregon Health & Science University
Bruce S. Bochner
Bruce S. Bochner Northwestern University
Efstathios Kastritis
Efstathios Kastritis National and Kapodistrian University of Athens
Meletios A. Dimopoulos
Meletios A. Dimopoulos National and Kapodistrian University of Athens
Larry V. McIntire
Larry V. McIntire Georgia Institute of Technology
Ronald L. Schnaar
Ronald L. Schnaar Johns Hopkins University School of Medicine
Kathleen J. Stebe
Kathleen J. Stebe University of Pennsylvania

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