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Jochen Walter

Jochen Walter

D-Index & Metrics

Biology and Biochemistry

D-Index
72
Citations
44550
World Ranking
6103
National Ranking
435

Overview

Jochen Walter is affiliated with the University of Bonn in Germany and has a research focus primarily in medicine and biochemistry, genetics, and molecular biology. Their scientific output includes significant work in physiology, molecular biology, neurology, pharmacology, and psychiatry and mental health.

Their research encompasses several key topics, including:

  • Alzheimer's disease research and treatments
  • Neuroinflammation and Neurodegeneration Mechanisms
  • Sphingolipid Metabolism and Signaling
  • Dementia and Cognitive Impairment Research
  • Cholinesterase and Neurodegenerative Diseases
  • Inflammation biomarkers and pathways
  • Lysosomal Storage Disorders Research

Walter has contributed to multiple scientific publications, including but not limited to the following papers:

  • Neuroinflammation in Alzheimer disease, 2024, Nature reviews. Immunology
  • Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation, 2021, Journal of Biological Chemistry
  • The coarse-grained plaque: a divergent Aβ plaque-type in early-onset Alzheimer's disease, 2020, Acta Neuropathologica
  • Sphingolipids in Alzheimer's disease, how can we target them?, 2020, Advanced Drug Delivery Reviews
  • A randomized, placebo-controlled experimental medicine study of RIPK1 inhibitor GSK2982772 in patients with moderate to severe rheumatoid arthritis, 2021, Arthritis Research & Therapy

Their frequent collaborative partners include Sathish Kumar, Helga E. de Vries, Pilar Martínez-Martínez, Simone M. Crivelli, and Sandra den Hoedt.

Walter has published in several recurring venues, evidencing a specialized focus in neuropathology and neurobiology. These venues include:

  • Acta Neuropathologica
  • Acta Neuropathologica Communications
  • Glia
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Scientific Reports

Their work spans multidisciplinary approaches within neurosciences, emphasizing mechanisms underlying Alzheimer's disease and related neurodegenerative disorders. The research integrates biochemical signaling pathways such as sphingolipid metabolism and investigates inflammatory biomarkers linked to cognitive decline.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Guidelines for the use and interpretation of assays for monitoring autophagy

    Daniel J. Klionsky;Fabio C. Abdalla;Hagai Abeliovich;Robert T. Abraham

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

    Carmen Venegas;Sathish Kumar;Bernardo S. Franklin;Tobias Dierkes

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Constitutive Phosphorylation of the Parkinson's Disease Associated α-Synuclein *

    Masayasu Okochi;Jochen Walter;Akihiko Koyama;Shigeo Nakajo

  • Inhibition of cyclin-dependent kinases, GSK-3β and CK1 by hymenialdisine, a marine sponge constituent

    L. Meijer;A. M W H Thunnissen;A. W. White;M. Garnier

  • Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

    Michael T. Heneka;Fabian Nadrigny;Tommy Regen;Ana Martinez-Hernandez

  • The presenilin 2 mutation (N141I) linked to familial Alzheimer disease (Volga German families) increases the secretion of amyloid β protein ending at the 42nd (or 43rd) residue

    Taisuke Tomita;Kei Maruyama;Takaomi C. Saido;Hideaki Kume

  • TLR2 Is a Primary Receptor for Alzheimer’s Amyloid β Peptide To Trigger Neuroinflammatory Activation

    Shirong Liu;Yang Liu;Wenlin Hao;Lisa Wolf

  • Nonsteroidal anti-inflammatory drugs repress β-secretase gene promoter activity by the activation of PPARγ

    Magdalena Sastre;Ilse Dewachter;Steffen Rossner;Nenad Bogdanovic

  • Focal glial activation coincides with increased BACE1 activation and precedes amyloid plaque deposition in APP[V717I] transgenic mice.

    Michael T Heneka;Magdalena Sastre;Lucia Dumitrescu-Ozimek;Ilse Dewachter

  • Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide.

    Sven Lammich;Masayasu Okochi;Masatoshi Takeda;Christoph Kaether

  • Phosphorylation Regulates Intracellular Trafficking of β-Secretase

    Jochen Walter;Regina Fluhrer;Bianka Hartung;Michael Willem

  • Maturation and Pro-peptide Cleavage of β-Secretase

    Anja Capell;Harald Steiner;Michael Willem;Hartmut Kaiser

  • Nitration of tyrosine 10 critically enhances amyloid β aggregation and plaque formation.

    Markus P. Kummer;Michael Hermes;Andrea Delekarte;Thea Hammerschmidt;Thea Hammerschmidt

  • Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer’s disease

    Dietmar Rudolf Thal;Jochen Walter;Takaomi C. Saido;Marcus Fändrich

  • The Alzheimer's disease-associated presenilins are differentially phosphorylated proteins located predominantly within the endoplasmic reticulum.

    Jochen Walter;Anja Capell;Jürgen Grünberg;Brigitte Pesold

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Sequential Proteolytic Processing of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Protein by Ectodomain Shedding and γ-Secretase-dependent Intramembranous Cleavage

    Patrick Wunderlich;Konstantin Glebov;Nadja Kemmerling;Nguyen T. Tien

Frequent Co-Authors

Christian Haass
Christian Haass Ludwig-Maximilians-Universität München
Michael T. Heneka
Michael T. Heneka University Hospital Bonn
Anja Capell
Anja Capell Ludwig-Maximilians-Universität München
Dieter Lütjohann
Dieter Lütjohann University Hospital Bonn
Markus Zweckstetter
Markus Zweckstetter German Center for Neurodegenerative Diseases
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Sergio Lavandero
Sergio Lavandero University of Chile
Christian Behl
Christian Behl Johannes Gutenberg University of Mainz
Frank Jessen
Frank Jessen University of Cologne
Evelina Gatti
Evelina Gatti Aix-Marseille University

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