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Dieter Lütjohann

Dieter Lütjohann

D-Index & Metrics

Medicine

D-Index
105
Citations
37546
World Ranking
6809
National Ranking
389

Overview

Dieter Lütjohann is affiliated with the University Hospital Bonn in Germany and has an extensive publication record focused on topics related to medicine, biochemistry, genetics, and molecular biology. Their research primarily contributes to several subfields, including surgery, molecular biology, immunology, endocrinology, diabetes and metabolism, as well as nutrition and dietetics.

The scholar's work covers a variety of topics, with a strong emphasis on cholesterol and lipid metabolism, lipoproteins and cardiovascular health, and cancer-related lipids and metabolism. Other areas of research include hormonal regulation and hypertension, fatty acid research and health, drug transport and resistance mechanisms, and atherosclerosis and cardiovascular diseases.

Frequent publication outlets for Lütjohann include the following journals:

  • Nutrients
  • International Journal of Molecular Sciences
  • Journal of Lipid Research
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Frontiers in Immunology

Their recent published papers indicate active involvement in diverse research projects, including:

  • Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination, 2021, Nature Metabolism
  • Efferocytosis potentiates the expression of arachidonate 15-lipoxygenase (ALOX15) in alternatively activated human macrophages through LXR activation, 2020, Cell Death and Differentiation
  • Phytosterols and Cardiovascular Disease, 2021, Current Atherosclerosis Reports
  • Dynamics of the enterohepatic circulation of bile acids in healthy humans, 2021, American Journal of Physiology-Gastrointestinal and Liver Physiology
  • Lactate dehydrogenase B regulates macrophage metabolism in the tumor microenvironment, 2021, Theranostics

Lütjohann frequently collaborates with several researchers, including:

  • Anja Kerksiek
  • Oliver Weingärtner
  • Frans Stellaard
  • Jogchum Plat
  • Silvia Friedrichs

The combination of research fields and topics associated with their publications reveals a multidisciplinary approach integrating clinical medicine and molecular biology techniques to address complex biomedical questions, relevant both for cardiovascular health and immune function.

Best Publications

  • Beneficial Effects of High Dietary Fiber Intake in Patients with Type 2 Diabetes Mellitus

    Manisha Chandalia;Abhimanyu Garg;D. Lutjohann;K. von Bergmann

  • Simvastatin strongly reduces levels of Alzheimer's disease β-amyloid peptides Aβ42 and Aβ40 in vitro and in vivo

    K. Fassbender;M. Simons;C. Bergmann;M. Stroick

  • Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion

    Liqing Yu;Robert E. Hammer;Jia Li-Hawkins;Klaus von Bergmann

  • Cholesterol homeostasis in human brain: evidence for an age-dependent flux of 24S-hydroxycholesterol from the brain into the circulation

    Dieter Lutjohann;Olof Breuer;Gunvor Ahlborg;Inger Nennesmo

  • Inhibition of Intestinal Cholesterol Absorption by Ezetimibe in Humans

    Thomas Sudhop;Dieter Lütjohann;Annette Kodal;Michael Igel

  • Cholesterol homeostasis in human brain: turnover of 24S-hydroxycholesterol and evidence for a cerebral origin of most of this oxysterol in the circulation

    Ingemar Björkhem;Dieter Lütjohann;Ulf Diczfalusy;Lars Ståhle

  • Treatment with simvastatin in normocholesterolemic patients with Alzheimer's disease: A 26-week randomized, placebo-controlled, double-blind trial.

    Mikael Simons;Frank Schwärzler;Dieter Lütjohann;Klaus Von Bergmann

  • Dietary cholesterol, rather than liver steatosis, leads to hepatic inflammation in hyperlipidemic mouse models of nonalcoholic steatohepatitis

    Kristiaan Wouters;Patrick J. van Gorp;Veerle Bieghs;Marion J. Gijbels

  • Plant sterols and plant stanols in the management of dyslipidaemia and prevention of cardiovascular disease

    Helena Gylling;Jogchum Plat;Stephen Turley;Henry N. Ginsberg

  • High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3

    Dominic Francis De Nardo;Larisa I Labzin;Hajime Kono;Reiko Seki

  • Plasma 24S-hydroxycholesterol (cerebrosterol) is increased in Alzheimer and vascular demented patients.

    Dieter Lütjohann;Dieter Lütjohann;Andreas Papassotiropoulos;Ingemar Björkhem;Sandra Locatelli

  • Defective cholesterol clearance limits remyelination in the aged central nervous system

    Ludovico Cantuti-Castelvetri;Dirk Fitzner;Dirk Fitzner;Mar Bosch-Queralt;Marie-Theres Weil;Marie-Theres Weil

  • Stimulation of Cholesterol Excretion by the Liver X Receptor Agonist Requires ATP-binding Cassette Transporters G5 and G8

    Liqing Yu;Jennifer York;Klaus von Bergmann;Dieter Lutjohann

  • Importance of a novel oxidative mechanism for elimination of brain cholesterol. Turnover of cholesterol and 24(S)-hydroxycholesterol in rat brain as measured with 18O2 techniques in vivo and in vitro.

    Ingemar Björkhem;Dieter Lütjohann;Olof Breuer;Augustinas Sakinis

  • Ezetimibe Effectively Reduces Plasma Plant Sterols in Patients With Sitosterolemia

    G. Salen;K. von Bergmann;D. Lütjohann;P. Kwiterovich

  • Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice

    M. Oksman;H. Iivonen;E. Hogyes;Z. Amtul

  • Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

    Maura Heverin;Nenad Bogdanovic;Dieter Lütjohann;Thomas Bayer

  • High‐dose statins and skeletal muscle metabolism in humans: A randomized, controlled trial

    Hannu Päivä;Karin M. Thelen;Rudy Van Coster;Joél Smet

  • Sterol absorption and sterol balance in phytosterolemia evaluated by deuterium-labeled sterols: effect of sitostanol treatment.

    D Lütjohann;I Björkhem;U.F. Beil;K von Bergmann

  • Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8.

    Knut E. Berge;Klaus von Bergmann;Dieter Lutjohann;Rudy Guerra

Frequent Co-Authors

Jogchum Plat
Jogchum Plat Maastricht University
Ingemar Björkhem
Ingemar Björkhem Karolinska University Hospital
Ulrich Laufs
Ulrich Laufs Saarland University
Ronald P. Mensink
Ronald P. Mensink Maastricht University
Ulf Diczfalusy
Ulf Diczfalusy Karolinska University Hospital
Frank Jessen
Frank Jessen University of Cologne
Eicke Latz
Eicke Latz German Rheumatism Research Centre
Marion J.J. Gijbels
Marion J.J. Gijbels Maastricht University
Wolfgang Maier
Wolfgang Maier University of Bonn
Tobias Hartmann
Tobias Hartmann Saarland University

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