1962 - Fellow of the American Association for the Advancement of Science (AAAS)
William J. Griffiths spends much of his time researching Biochemistry, Chromatography, Mass spectrometry, Sterol and Cholesterol. His work is connected to Arachidonic acid, Retinoid X receptor, Fatty acid, Docosahexaenoic acid and Plasma protein binding, as a part of Biochemistry. His work focuses on many connections between Chromatography and other disciplines, such as Lipidomics, that overlap with his field of interest in Mass spectrometric, Proteomics, Environmental chemistry and Human disease.
In his study, Hydroxylamine, Steroid sulfate, Cholestene, Urine and Glucuronide is strongly linked to Ion chromatography, which falls under the umbrella field of Mass spectrometry. His Sterol research includes elements of Liver X receptor, Reactive oxygen species, Steroid and Endogenous enzymes. The study incorporates disciplines such as Metabolite, Neurodegeneration, Derivatization and Blood–brain barrier in addition to Cholesterol.
His main research concerns Biochemistry, Chromatography, Mass spectrometry, Tandem mass spectrometry and Cholesterol. Biochemistry is frequently linked to Molecular biology in his study. William J. Griffiths has included themes like Reagent and Steroid in his Chromatography study.
His study explores the link between Mass spectrometry and topics such as Dissociation that cross with problems in Collision-induced dissociation and Mass spectrum. William J. Griffiths has researched Tandem mass spectrometry in several fields, including Peptide and Trypsin. His Cholesterol and Sterol and Oxysterol investigations all form part of his Cholesterol research activities.
William J. Griffiths mainly investigates Cholesterol, Biochemistry, Sterol, Oxysterol and Internal medicine. His studies in Cholesterol integrate themes in fields like G protein-coupled receptor, Autoimmune disease, Bile acid, Metabolic pathway and Nuclear receptor. His Sterol research incorporates themes from Chromatography, CYP27A1, Cytochrome P450, Mass spectrometry imaging and Smith–Lemli–Opitz syndrome.
The Gas chromatography and Tandem mass spectrometry research William J. Griffiths does as part of his general Chromatography study is frequently linked to other disciplines of science, such as Deuterium labelled, therefore creating a link between diverse domains of science. The various areas that William J. Griffiths examines in his Internal medicine study include Gastroenterology and Endocrinology. His research in Liquid chromatography–mass spectrometry focuses on subjects like Sample preparation, which are connected to Mass spectrometry.
His primary areas of investigation include Cholesterol, Biochemistry, Sterol, Oxysterol and Lipidomics. He combines subjects such as Autoimmune disease and Lysosomal acid lipase deficiency with his study of Cholesterol. His is doing research in Cerebrotendinous Xanthomatosis, Steroid, Cholesterol metabolism, Metabolism and Bile acid biosynthesis, both of which are found in Biochemistry.
The Cerebrotendinous Xanthomatosis study combines topics in areas such as Hydrolysis, Derivatization, Mass spectrometry, Lipid metabolism and Niemann–Pick disease, type C. The concepts of his Sterol study are interwoven with issues in Metabolite, Knockout mouse, CYP27A1, Smith–Lemli–Opitz syndrome and Metabolic pathway. His research investigates the link between Oxysterol and topics such as Liver X receptor that cross with problems in Lipid signaling, G protein-coupled receptor, Receptor and Neurogenesis.
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Docosahexaenoic Acid, a Ligand for the Retinoid X Receptor in Mouse Brain
Alexander Mata de Urquiza;Suya Liu;Maria Sjöberg;Rolf H. Zetterström.
Shorthand notation for lipid structures derived from mass spectrometry
Gerhard Liebisch;Juan Antonio Vizcaíno;Harald Köfeler;Martin Trötzmüller.
Journal of Lipid Research (2013)
Targeted Metabolomics for Biomarker Discovery
William J. Griffiths;Therese Koal;Yuqin Wang;Matthias Kohl.
Angewandte Chemie (2010)
The Transcription Factor STAT-1 Couples Macrophage Synthesis of 25-Hydroxycholesterol to the Interferon Antiviral Response
Mathieu Blanc;Wei Yuan Hsieh;Kevin A. Robertson;Kai A. Kropp.
Polyunsaturated fatty acids including docosahexaenoic and arachidonic acid bind to the retinoid X receptor alpha ligand-binding domain.
Johan Lengqvist;Johan Lengqvist;Alexander Mata de Urquiza;Ann Charlotte Bergman;Timothy M. Willson.
Molecular & Cellular Proteomics (2004)
Mass spectrometry: from proteomics to metabolomics and lipidomics
William J. Griffiths;Yuqin Wang.
Chemical Society Reviews (2009)
Electrospray and tandem mass spectrometry in biochemistry.
William J. Griffiths;Andreas P. Jonsson;Suya Liu;Dilip K. Rai.
Biochemical Journal (2001)
Tandem mass spectrometry in the study of fatty acids, bile acids, and steroids.
William J. Griffiths.
Mass Spectrometry Reviews (2003)
Bile acids: analysis in biological fluids and tissues.
William J. Griffiths;Jan Sjövall.
Journal of Lipid Research (2010)
Release of metabolic enzymes by Giardia in response to interaction with intestinal epithelial cells.
Emma Ringqvist;J.E. Daniel Palm;J.E. Daniel Palm;Hanna Skarin;Adrian B. Hehl.
Molecular and Biochemical Parasitology (2008)
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