2023 - Research.com Biology and Biochemistry in France Leader Award
His primary areas of study are Presenilin, Biochemistry, Amyloid precursor protein, Alzheimer's disease and Molecular biology. His Presenilin research includes elements of Amyloid beta, Neurodegeneration, Intracellular, Cell biology and Amyloid precursor protein secretase. His work deals with themes such as Caspase 3, Ubiquitin and Immunology, which intersect with Cell biology.
His Amyloid precursor protein research is multidisciplinary, incorporating elements of Neuroscience and Pathogenesis. His Alzheimer's disease research includes themes of Endocrinology and Ryanodine receptor, Endoplasmic reticulum. His Molecular biology research incorporates themes from HEK 293 cells, Cell culture, Apoptosis, Point mutation and Staurosporine.
His scientific interests lie mostly in Biochemistry, Cell biology, Presenilin, Molecular biology and Amyloid precursor protein. His Biochemistry study frequently draws connections between related disciplines such as Amyloid precursor protein secretase. Frédéric Checler combines subjects such as HEK 293 cells and Apoptosis, Programmed cell death with his study of Cell biology.
His Presenilin research is multidisciplinary, incorporating elements of Genetics, Endoplasmic reticulum, Neuroscience and Senile plaques. His studies deal with areas such as Genetically modified mouse and Amyloid beta as well as Amyloid precursor protein. His Alzheimer's disease study combines topics in areas such as Endocrinology and Amyloid.
Frédéric Checler spends much of his time researching Cell biology, Alzheimer's disease, Neuroscience, Amyloid precursor protein and Synaptic plasticity. His biological study spans a wide range of topics, including PINK1, Mitophagy and Presenilin. Specifically, his work in Presenilin is concerned with the study of Nicastrin.
His study on Alzheimer's disease is covered under Pathology. His work deals with themes such as Endoplasmic reticulum, Disease, Alpha-synuclein and Transcription factor, which intersect with Neuroscience. His Amyloid precursor protein research is multidisciplinary, incorporating perspectives in Genetically modified mouse, Amyloid beta, Neuroinflammation and Amyloid.
His primary areas of investigation include Alzheimer's disease, Neuroscience, Cell biology, Amyloid precursor protein and Presenilin. Frédéric Checler has included themes like Neurotoxicity, Amyloid beta, Neurodegeneration and Function in his Alzheimer's disease study. His Amyloid beta research includes elements of Ryanodine receptor, Endoplasmic reticulum and Endocrinology.
His study explores the link between Neuroscience and topics such as Synaptic plasticity that cross with problems in Long-term potentiation and Genetically modified mouse. His Cell biology research integrates issues from Psychological repression, Chromatin immunoprecipitation, PINK1, Mitophagy and Regulation of gene expression. His study on P3 peptide and Amyloid precursor protein secretase is often connected to Genetic association as part of broader study in Amyloid precursor protein.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif.
Intraneuronal Aβ42 Accumulation in Human Brain
Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent.
American Journal of Pathology (2000)
Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain
Dieder Moechars;Ilse Dewachter;Kristin Lorent;Delphine Reversé.
Journal of Biological Chemistry (1999)
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent.
Nature Medicine (1998)
Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.
Yoo-Hun Suh;Frederic Checler.
Pharmacological Reviews (2002)
Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease
Journal of Neurochemistry (2002)
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai.
Proceedings of the National Academy of Sciences of the United States of America (1999)
Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.
De-Hua Chui;Hiroshi Tanahashi;Kazuharu Ozawa;Sachiya Ikeda.
Nature Medicine (1999)
Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.
Suzanne Benjannet;Aram Elagoz;Louise Wickham;Maya Mamarbachi.
Journal of Biological Chemistry (2001)
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Fusheng Chen;Hiroshi Hasegawa;Hiroshi Hasegawa;Gerold Schmitt-Ulms;Toshitaka Kawarai.
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