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Frédéric Checler

Frédéric Checler

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Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
35425
World Ranking
2659
National Ranking
60

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Frédéric Checler is affiliated with Grenoble Alpes University in France and has contributed extensively to research in medicine, particularly focusing on biochemistry, genetics, and molecular biology. Their work spans a range of topics related to neurodegenerative diseases, cellular processes, and molecular mechanisms.

The main fields of study for Checler include Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields of study emphasize Molecular Biology, Physiology, Epidemiology, Cell Biology, and Pharmacology.

Checler's research addresses several key topics:

  • Alzheimer's disease research and treatments
  • Autophagy in Disease and Therapy
  • Mitochondrial Function and Pathology
  • Cholinesterase and Neurodegenerative Diseases
  • Endoplasmic Reticulum Stress and Disease
  • Parkinson's Disease Mechanisms and Treatments
  • Cellular transport and secretion

Their notable recent publications include:

  • "Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains" (2020), published in Acta Neuropathologica
  • "Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches" (2022), published in Molecular Psychiatry
  • "Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α" (2020), published in Cell Reports
  • "The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology" (2020), published in Cells
  • "Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease" (2020), published in International Journal of Molecular Sciences

Frequent publication venues for Checler's work include:

  • Cells
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Molecular Psychiatry
  • Journal of Biological Chemistry

Checler collaborates regularly with several co-authors, including:

  • Mounia Chami
  • Fanny Eysert
  • Raphaëlle Pardossi-Piquard
  • Charlotte Bauer
  • Eric Duplan

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Intraneuronal Aβ42 Accumulation in Human Brain

    Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent

  • Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

    Dieder Moechars;Ilse Dewachter;Kristin Lorent;Delphine Reversé

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

  • Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

    Yoo-Hun Suh;Frederic Checler

  • Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

    Frédéric Checler

  • Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

    Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai

  • Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

    De-Hua Chui;Hiroshi Tanahashi;Kazuharu Ozawa;Sachiya Ikeda

  • TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

    Fusheng Chen;Hiroshi Hasegawa;Hiroshi Hasegawa;Gerold Schmitt-Ulms;Toshitaka Kawarai

  • Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

    Suzanne Benjannet;Aram Elagoz;Louise Wickham;Maya Mamarbachi

  • Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP

    Raphaëlle Pardossi-Piquard;Agnès Petit;Toshitaka Kawarai;Claire Sunyach

  • Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer’s disease

    Yasumasa Ohyagi;Hideaki Asahara;De Hua Chui;Yuko Tsuruta

  • The Disintegrins ADAM10 and TACE Contribute to the Constitutive and Phorbol Ester-regulated Normal Cleavage of the Cellular Prion Protein *

    Bruno Vincent;Erwan Paitel;Paul Saftig;Yveline Frobert

  • Phenotype associated with APP duplication in five families

    Lucie Cabrejo;Lucie Guyant-Maréchal;Annie Laquerrière;Martine Vercelletto

  • Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

    Bénédicte Oulès;Dolores Del Prete;Dolores Del Prete;Barbara Greco;Xuexin Zhang

  • Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability

    Chris De Jonghe;Cary Esselens;Samir Kumar-Singh;Katleen Craessaerts

  • Wild-type but Not Parkinson's Disease-related Ala-53 → Thr Mutant α-Synuclein Protects Neuronal Cells from Apoptotic Stimuli

    Cristine Alves da Costa;Karine Ancolio;Frédéric Checler

  • Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715 → Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease

    K. Ancolio;C. Dumanchin;H. Barelli;J. M. Warter

  • Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

    Jo Van Dorpe;Liesbet Smeijers;Ilse Dewachter;Dieter Nuyens

  • New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.

    A Petit;F Bihel;C Alvès da Costa;O Pourquié

Frequent Co-Authors

Jean-Pierre Vincent
Jean-Pierre Vincent Centre national de la recherche scientifique, CNRS
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Patrick Kitabgi
Patrick Kitabgi Grenoble Alpes University
Philippe Marambaud
Philippe Marambaud Feinstein Institute for Medical Research
Jean Martinez
Jean Martinez University of Montpellier
Paul E. Fraser
Paul E. Fraser University of Toronto
Patrick Auberger
Patrick Auberger Grenoble Alpes University
Huaxi Xu
Huaxi Xu Xiamen University
Jean Mazella
Jean Mazella Centre national de la recherche scientifique, CNRS

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