What is he best known for?
The fields of study he is best known for:
His primary areas of study are Presenilin, Biochemistry, Amyloid precursor protein, Alzheimer's disease and Molecular biology.
His Presenilin research includes elements of Amyloid beta, Neurodegeneration, Intracellular, Cell biology and Amyloid precursor protein secretase.
His work deals with themes such as Caspase 3, Ubiquitin and Immunology, which intersect with Cell biology.
His Amyloid precursor protein research is multidisciplinary, incorporating elements of Neuroscience and Pathogenesis.
His Alzheimer's disease research includes themes of Endocrinology and Ryanodine receptor, Endoplasmic reticulum.
His Molecular biology research incorporates themes from HEK 293 cells, Cell culture, Apoptosis, Point mutation and Staurosporine.
His most cited work include:
- Intraneuronal Aβ42 Accumulation in Human Brain (848 citations)
- Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain (653 citations)
- Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides. (497 citations)
What are the main themes of his work throughout his whole career to date?
His scientific interests lie mostly in Biochemistry, Cell biology, Presenilin, Molecular biology and Amyloid precursor protein.
His Biochemistry study frequently draws connections between related disciplines such as Amyloid precursor protein secretase.
Frédéric Checler combines subjects such as HEK 293 cells and Apoptosis, Programmed cell death with his study of Cell biology.
His Presenilin research is multidisciplinary, incorporating elements of Genetics, Endoplasmic reticulum, Neuroscience and Senile plaques.
His studies deal with areas such as Genetically modified mouse and Amyloid beta as well as Amyloid precursor protein.
His Alzheimer's disease study combines topics in areas such as Endocrinology and Amyloid.
He most often published in these fields:
- Biochemistry (34.69%)
- Cell biology (33.44%)
- Presenilin (24.37%)
What were the highlights of his more recent work (between 2013-2021)?
- Cell biology (33.44%)
- Alzheimer's disease (15.62%)
- Neuroscience (13.75%)
In recent papers he was focusing on the following fields of study:
Frédéric Checler spends much of his time researching Cell biology, Alzheimer's disease, Neuroscience, Amyloid precursor protein and Synaptic plasticity.
His biological study spans a wide range of topics, including PINK1, Mitophagy and Presenilin.
Specifically, his work in Presenilin is concerned with the study of Nicastrin.
His study on Alzheimer's disease is covered under Pathology.
His work deals with themes such as Endoplasmic reticulum, Disease, Alpha-synuclein and Transcription factor, which intersect with Neuroscience.
His Amyloid precursor protein research is multidisciplinary, incorporating perspectives in Genetically modified mouse, Amyloid beta, Neuroinflammation and Amyloid.
Between 2013 and 2021, his most popular works were:
- Ryanodine receptors: physiological function and deregulation in Alzheimer disease. (87 citations)
- Ryanodine receptors: physiological function and deregulation in Alzheimer disease. (87 citations)
- Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology (85 citations)
In his most recent research, the most cited papers focused on:
His primary areas of investigation include Alzheimer's disease, Neuroscience, Cell biology, Amyloid precursor protein and Presenilin.
Frédéric Checler has included themes like Neurotoxicity, Amyloid beta, Neurodegeneration and Function in his Alzheimer's disease study.
His Amyloid beta research includes elements of Ryanodine receptor, Endoplasmic reticulum and Endocrinology.
His study explores the link between Neuroscience and topics such as Synaptic plasticity that cross with problems in Long-term potentiation and Genetically modified mouse.
His Cell biology research integrates issues from Psychological repression, Chromatin immunoprecipitation, PINK1, Mitophagy and Regulation of gene expression.
His study on P3 peptide and Amyloid precursor protein secretase is often connected to Genetic association as part of broader study in Amyloid precursor protein.
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