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Frédéric Checler

Frédéric Checler

Grenoble Alpes University
France

Award Badge
Biology and Biochemistry
France
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
88
Citations
35425
World Ranking
2659
National Ranking
60

Frédéric Checler publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Frédéric Checler sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 353 publications — 86th percentile

86% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Frédéric Checler D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Frédéric Checler sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 88 D-Index — 87th percentile

87% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in France Leader Award

Overview

Frédéric Checler is affiliated with Grenoble Alpes University in France and has contributed extensively to research in medicine, particularly focusing on biochemistry, genetics, and molecular biology. Their work spans a range of topics related to neurodegenerative diseases, cellular processes, and molecular mechanisms.

The main fields of study for Checler include Medicine and Biochemistry, Genetics and Molecular Biology. Their subfields of study emphasize Molecular Biology, Physiology, Epidemiology, Cell Biology, and Pharmacology.

Checler's research addresses several key topics:

  • Alzheimer's disease research and treatments
  • Autophagy in Disease and Therapy
  • Mitochondrial Function and Pathology
  • Cholinesterase and Neurodegenerative Diseases
  • Endoplasmic Reticulum Stress and Disease
  • Parkinson's Disease Mechanisms and Treatments
  • Cellular transport and secretion

Their notable recent publications include:

  • "Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer's disease models and human brains" (2020), published in Acta Neuropathologica
  • "Mitophagy in Alzheimer's disease: Molecular defects and therapeutic approaches" (2022), published in Molecular Psychiatry
  • "Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α" (2020), published in Cell Reports
  • "The Endoplasmic Reticulum Stress/Unfolded Protein Response and Their Contributions to Parkinson's Disease Physiopathology" (2020), published in Cells
  • "Molecular Dysfunctions of Mitochondria-Associated Membranes (MAMs) in Alzheimer's Disease" (2020), published in International Journal of Molecular Sciences

Frequent publication venues for Checler's work include:

  • Cells
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Acta Neuropathologica
  • Molecular Psychiatry
  • Journal of Biological Chemistry

Checler collaborates regularly with several co-authors, including:

  • Mounia Chami
  • Fanny Eysert
  • Raphaëlle Pardossi-Piquard
  • Charlotte Bauer
  • Eric Duplan

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

    Daniel J. Klionsky;Amal Kamal Abdel-Aziz;Sara Abdelfatah;Mahmoud Abdellatif

  • Intraneuronal Aβ42 Accumulation in Human Brain

    Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent

  • Early Phenotypic Changes in Transgenic Mice That Overexpress Different Mutants of Amyloid Precursor Protein in Brain

    Dieder Moechars;Ilse Dewachter;Kristin Lorent;Delphine Reversé

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

  • Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.

    Yoo-Hun Suh;Frederic Checler

  • Processing of the β‐Amyloid Precursor Protein and Its Regulation in Alzheimer's Disease

    Frédéric Checler

  • Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

    Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai

  • Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation.

    De-Hua Chui;Hiroshi Tanahashi;Kazuharu Ozawa;Sachiya Ikeda

  • TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.

    Fusheng Chen;Hiroshi Hasegawa;Hiroshi Hasegawa;Gerold Schmitt-Ulms;Toshitaka Kawarai

  • Post-translational processing of beta-secretase (beta-amyloid-converting enzyme) and its ectodomain shedding. The pro- and transmembrane/cytosolic domains affect its cellular activity and amyloid-beta production.

    Suzanne Benjannet;Aram Elagoz;Louise Wickham;Maya Mamarbachi

  • Presenilin-Dependent Transcriptional Control of the Aβ-Degrading Enzyme Neprilysin by Intracellular Domains of βAPP and APLP

    Raphaëlle Pardossi-Piquard;Agnès Petit;Toshitaka Kawarai;Claire Sunyach

  • Intracellular Aβ42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer’s disease

    Yasumasa Ohyagi;Hideaki Asahara;De Hua Chui;Yuko Tsuruta

  • The Disintegrins ADAM10 and TACE Contribute to the Constitutive and Phorbol Ester-regulated Normal Cleavage of the Cellular Prion Protein *

    Bruno Vincent;Erwan Paitel;Paul Saftig;Yveline Frobert

  • Phenotype associated with APP duplication in five families

    Lucie Cabrejo;Lucie Guyant-Maréchal;Annie Laquerrière;Martine Vercelletto

  • Ryanodine Receptor Blockade Reduces Amyloid-β Load and Memory Impairments in Tg2576 Mouse Model of Alzheimer Disease

    Bénédicte Oulès;Dolores Del Prete;Dolores Del Prete;Barbara Greco;Xuexin Zhang

  • Pathogenic APP mutations near the γ-secretase cleavage site differentially affect Aβ secretion and APP C-terminal fragment stability

    Chris De Jonghe;Cary Esselens;Samir Kumar-Singh;Katleen Craessaerts

  • Wild-type but Not Parkinson's Disease-related Ala-53 → Thr Mutant α-Synuclein Protects Neuronal Cells from Apoptotic Stimuli

    Cristine Alves da Costa;Karine Ancolio;Frédéric Checler

  • Unusual phenotypic alteration of β amyloid precursor protein (βAPP) maturation by a new Val-715 → Met βAPP-770 mutation responsible for probable early-onset Alzheimer’s disease

    K. Ancolio;C. Dumanchin;H. Barelli;J. M. Warter

  • Prominent Cerebral Amyloid Angiopathy in Transgenic Mice Overexpressing the London Mutant of Human APP in Neurons

    Jo Van Dorpe;Liesbet Smeijers;Ilse Dewachter;Dieter Nuyens

  • New protease inhibitors prevent gamma-secretase-mediated production of Abeta40/42 without affecting Notch cleavage.

    A Petit;F Bihel;C Alvès da Costa;O Pourquié

Frequent Co-Authors

Jean-Pierre Vincent
Jean-Pierre Vincent Centre national de la recherche scientifique, CNRS
Peter St George-Hyslop
Peter St George-Hyslop Columbia University
Patrick Kitabgi
Patrick Kitabgi Grenoble Alpes University
Philippe Marambaud
Philippe Marambaud Feinstein Institute for Medical Research
Jean Martinez
Jean Martinez University of Montpellier
Jean-Charles Lambert
Jean-Charles Lambert Inserm
Paul E. Fraser
Paul E. Fraser University of Toronto
Patrick Auberger
Patrick Auberger Grenoble Alpes University
Huaxi Xu
Huaxi Xu Xiamen University
Jean Mazella
Jean Mazella Centre national de la recherche scientifique, CNRS

External Links

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Best Scientists Citing Frédéric Checler

Huaxi Xu

Huaxi Xu

Xiamen University

Publications: 83

Fred Van Leuven

Fred Van Leuven

KU Leuven

Publications: 62

Peter St George-Hyslop

Peter St George-Hyslop

Columbia University

Publications: 61

Bart De Strooper

Bart De Strooper

KU Leuven

Publications: 58

Colin L. Masters

Colin L. Masters

University of Melbourne

Publications: 56

Ralph A. Nixon

Ralph A. Nixon

Nathan Kline Institute for Psychiatric Research

Publications: 54

Patrick Kitabgi

Patrick Kitabgi

Grenoble Alpes University

Publications: 51

Oliver Wirths

Oliver Wirths

University of Göttingen

Publications: 50

Thomas A. Bayer

Thomas A. Bayer

University of Göttingen

Publications: 49

David Westaway

David Westaway

University of Alberta

Publications: 48

Nabil G. Seidah

Nabil G. Seidah

University of Montreal

Publications: 48

Eliezer Masliah

Eliezer Masliah

National Institutes of Health

Publications: 46

Anthony J. Turner

Anthony J. Turner

University of Leeds

Publications: 46

Paul E. Fraser

Paul E. Fraser

University of Toronto

Publications: 45

Bengt Winblad

Bengt Winblad

Karolinska Institute

Publications: 45

Christian Haass

Christian Haass

Ludwig-Maximilians-Universität München

Publications: 41

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