Cell biology, Alzheimer's disease, Neuroscience, Biochemistry and Amyloid precursor protein secretase are his primary areas of study. His Cell biology research is multidisciplinary, incorporating perspectives in Receptor, Gene expression, Presenilin and Molecular biology. His Receptor research is multidisciplinary, incorporating elements of TREM2, Microglia, Depolarization and Phosphorylation.
His study in Alzheimer's disease is interdisciplinary in nature, drawing from both Extracellular, Endocrinology, Cholesterol and Human brain. His biological study spans a wide range of topics, including Glutamate receptor, Immunology, Hormone, Signal transduction and Disease. His research on Amyloid precursor protein secretase concerns the broader Amyloid precursor protein.
Huaxi Xu focuses on Cell biology, Neuroscience, Amyloid precursor protein, Amyloid precursor protein secretase and Alzheimer's disease. His Cell biology study combines topics from a wide range of disciplines, such as Microglia, Biochemistry, Presenilin and Downregulation and upregulation. His Neuroscience research incorporates elements of Synaptic plasticity, Pathogenesis, Glutamate receptor and Neurodegeneration, Disease.
Huaxi Xu interconnects SNX27, Caspase and Senile plaques in the investigation of issues within Amyloid precursor protein. While the research belongs to areas of Alzheimer's disease, Huaxi Xu spends his time largely on the problem of Endocrinology, intersecting his research to questions surrounding Neuroprotection. His work deals with themes such as TREM2 and Phosphorylation, which intersect with Signal transduction.
Huaxi Xu mainly investigates Cell biology, Neuroscience, TREM2, Disease and Receptor. His work carried out in the field of Cell biology brings together such families of science as Downregulation and upregulation, Gene knockdown and Amyloid precursor protein. His studies in Gene knockdown integrate themes in fields like Protein kinase C, Rottlerin, Alzheimer's disease, Senile plaques and Amyloid precursor protein secretase.
The concepts of his Neuroscience study are interwoven with issues in Synaptic plasticity, Trisomy and Pathogenesis. His TREM2 study integrates concerns from other disciplines, such as Phenotype and Genetics. Huaxi Xu has included themes like PICALM and LRP1 in his Receptor study.
His primary scientific interests are in Cell biology, Microglia, TREM2, Receptor and Neuroinflammation. His research is interdisciplinary, bridging the disciplines of Amyloid precursor protein and Cell biology. Huaxi Xu has researched Microglia in several fields, including Apolipoprotein E, Disease, Dementia and Neurology.
His study explores the link between TREM2 and topics such as Phosphorylation that cross with problems in Depolarization, Amyloid beta, Signal transduction and Secretion. His work carried out in the field of Receptor brings together such families of science as PICALM and LRP1. His studies deal with areas such as NF-κB, MEN1, Cytokine and Endocrinology as well as Neuroinflammation.
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Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Chia Chan Liu;Takahisa Kanekiyo;Huaxi Xu;Guojun Bu.
Nature Reviews Neurology (2013)
Intraneuronal Aβ42 Accumulation in Human Brain
Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent.
American Journal of Pathology (2000)
APP processing in Alzheimer's disease
Yun-wu Zhang;Robert Thompson;Han Zhang;Han Zhang;Huaxi Xu;Huaxi Xu.
Molecular Brain (2011)
Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology
Reisuke H. Takahashi;Reisuke H. Takahashi;Teresa A. Milner;Feng Li;Ellen E. Nam.
American Journal of Pathology (2002)
Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.
Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent.
Nature Medicine (1998)
Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling
Laura Gasparini;Gunnar K. Gouras;Rong Wang;Rachel S. Gross.
The Journal of Neuroscience (2001)
ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?
Takahisa Kanekiyo;Huaxi Xu;Guojun Bu;Guojun Bu.
Chaperones increase association of tau protein with microtubules
Fei Dou;William J. Netzer;Kentaro Tanemura;Feng Li.
Proceedings of the National Academy of Sciences of the United States of America (2003)
Association of γ-Secretase with Lipid Rafts in Post-Golgi and Endosome Membranes
Kulandaivelu S. Vetrivel;Haipeng Cheng;William Lin;Takashi Sakurai.
Journal of Biological Chemistry (2004)
Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides
Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai.
Proceedings of the National Academy of Sciences of the United States of America (1999)
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