World's Best Scientists 2026 revealed!
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Biology and Biochemistry
China
2023

D-Index & Metrics

Neuroscience

D-Index
93
Citations
35176
World Ranking
978
National Ranking
12

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in China Leader Award

Overview

Huaxi Xu is affiliated with Xiamen University in China, contributing extensively to the fields of neuroscience, medicine, and biochemistry, genetics, and molecular biology. Their research encompasses a broad range of subfields with particular focus on neurology, physiology, molecular biology, immunology, and cellular and molecular neuroscience.

Their scholarly work addresses several key research topics, including:

  • Neuroinflammation and neurodegeneration mechanisms
  • Alzheimer's disease research and treatments
  • Genetics and neurodevelopmental disorders
  • Parkinson's disease mechanisms and treatments
  • Inflammation biomarkers and pathways
  • Immune cells in cancer
  • Nuclear receptors and signaling

Xu has published numerous papers in notable scientific venues. Frequent publication venues include:

  • Molecular Neurodegeneration
  • Frontiers in Cell and Developmental Biology
  • Journal of Neuroscience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Neuroscience

Recent representative papers demonstrate a range of topics related to neurodegenerative disease mechanisms and potential therapeutic approaches:

  • "Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease" (2020) in Molecular Neurodegeneration
  • "Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72" (2020) in Nature Neuroscience
  • "Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance" (2022) in Nature Metabolism
  • "β-amyloid redirects norepinephrine signaling to activate the pathogenic GSK3β/tau cascade" (2020) in Science Translational Medicine
  • "A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer's disease" (2022) in Science Translational Medicine

Frequent collaborators include Yun-wu Zhang, Xian Zhang, Yingjun Zhao, Hong Luo, and Timothy Y. Huang, reflecting sustained research partnerships across multiple studies.

Best Publications

  • Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

    Chia Chan Liu;Takahisa Kanekiyo;Huaxi Xu;Guojun Bu

  • Intraneuronal Aβ42 Accumulation in Human Brain

    Gunnar K. Gouras;Gunnar K. Gouras;Julia Tsai;Jan Naslund;Bruno Vincent

  • APP processing in Alzheimer's disease

    Yun-wu Zhang;Robert Thompson;Han Zhang;Han Zhang;Huaxi Xu;Huaxi Xu

  • Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.

    Tiantian Guo;Denghong Zhang;Yuzhe Zeng;Timothy Y. Huang

  • Intraneuronal Alzheimer Aβ42 Accumulates in Multivesicular Bodies and Is Associated with Synaptic Pathology

    Reisuke H. Takahashi;Reisuke H. Takahashi;Teresa A. Milner;Feng Li;Ellen E. Nam

  • TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

    Yingjun Zhao;Xilin Wu;Xiaoguang Li;Lu Lin Jiang

  • ApoE and Aβ in Alzheimer's disease: accidental encounters or partners?

    Takahisa Kanekiyo;Huaxi Xu;Guojun Bu;Guojun Bu

  • Estrogen reduces neuronal generation of Alzheimer beta-amyloid peptides.

    Huaxi Xu;Gunnar K. Gouras;Jeffrey P. Greenfield;Bruno Vincent

  • Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

    Yuka Atagi;Chia Chen Liu;Meghan M. Painter;Xiao Fen Chen

  • Stimulation of β-Amyloid Precursor Protein Trafficking by Insulin Reduces Intraneuronal β-Amyloid and Requires Mitogen-Activated Protein Kinase Signaling

    Laura Gasparini;Gunnar K. Gouras;Rong Wang;Rachel S. Gross

  • Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

    Shichun Tu;Shu-ichi Okamoto;Stuart A Lipton;Huaxi Xu

  • Inhibition of amyloid-β aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761

    Yuan Luo;Julie V. Smith;Vijaykumar Paramasivam;Adam Burdick

  • Endoplasmic reticulum and trans-Golgi network generate distinct populations of Alzheimer β-amyloid peptides

    Jeffrey P. Greenfield;Julia Tsai;Gunnar K. Gouras;Gunnar K. Gouras;Bing Hai

  • Hypoxia-inducible Factor 1α (HIF-1α)-mediated Hypoxia Increases BACE1 Expression and β-Amyloid Generation

    Xian Zhang;Kun Zhou;Kun Zhou;Ruishan Wang;Ruishan Wang;Jiankun Cui

  • Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer's amyloid peptides via up-regulating BACE1 transcription

    Yaomin Chen;Kun Zhou;Ruishan Wang;Yun Liu

  • Proteolytic processing of Alzheimer’s β-amyloid precursor protein

    Han Zhang;Han Zhang;Qilin Ma;Yun-wu Zhang;Huaxi Xu;Huaxi Xu

  • Does insulin dysfunction play a role in Alzheimer's disease?

    Laura Gasparini;William J. Netzer;Paul Greengard;Huaxi Xu

  • Testosterone reduces neuronal secretion of Alzheimer's β-amyloid peptides

    Gunnar K. Gouras;Huaxi Xu;Rachel S. Gross;Jeffrey P. Greenfield

  • Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer???s Disease Models

    C.Y. Daniel Lee;C.Y. Daniel Lee;Anthony Daggett;Anthony Daggett;Xiaofeng Gu;Xiaofeng Gu;Lu-Lin Jiang

  • Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model.

    Li Zhong;Ying Xu;Rengong Zhuo;Tingting Wang

  • Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

    Huaxi Xu;David Sweeney;Rong Wang;Gopal Thinakaran

  • Potential roles of insulin and IGF-1 in Alzheimer's disease

    Laura Gasparini;Huaxi Xu;Huaxi Xu

  • Inhibition of amyloid-beta aggregation and caspase-3 activation by the Ginkgo biloba extract EGb761

    Yuan Luo;Julie Smith;Kenneth J. Curry;Justin Buford

Frequent Co-Authors

Xian Zhang
Xian Zhang Hefei Institutes of Physical Science
Paul Greengard
Paul Greengard Rockefeller University
Gunnar K. Gouras
Gunnar K. Gouras Lund University
Stuart A. Lipton
Stuart A. Lipton Scripps Research Institute
Han Zhang
Han Zhang Shenzhen University
Eliezer Masliah
Eliezer Masliah National Institutes of Health
Sangram S. Sisodia
Sangram S. Sisodia University of Chicago
Hui Zheng
Hui Zheng Baylor College of Medicine
William C. Mobley
William C. Mobley University of California, San Diego

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