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Neuroscience

D-Index
71
Citations
20938
World Ranking
2389
National Ranking
1130

Overview

Hui Zheng is affiliated with Baylor College of Medicine in the United States. Their research primarily spans the fields of biochemistry, genetics, molecular biology, medicine, and neuroscience. Within these broad categories, Zheng's work focuses on subfields including molecular biology, neurology, physiology, immunology, and epidemiology.

The scientist's recent publications cover several significant topics related to neuroinflammation, neurodegeneration, and Alzheimer's disease. Notable papers include:

  • Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease (2020, Journal of Clinical Investigation)
  • Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models (2020, Cell Reports)
  • Endothelial C3a receptor mediates vascular inflammation and blood-brain barrier permeability during aging (2020, Journal of Clinical Investigation)
  • Concerted type I interferon signaling in microglia and neural cells promotes memory impairment associated with amyloid β plaques (2022, Immunity)
  • Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading (2021, Proceedings of the National Academy of Sciences)

The research topics covered by Zheng include:

  • Neuroinflammation and Neurodegeneration Mechanisms
  • Alzheimer's disease research and treatments
  • Autophagy in Disease and Therapy
  • Cellular transport and secretion
  • Tryptophan and brain disorders
  • Barrier Structure and Function Studies
  • Eicosanoids and Hypertension Pharmacology

Hui Zheng's frequent co-authors are:

  • Nicholas E. Propson
  • Baiping Wang
  • Wen Xiong
  • Manasee Gedam
  • Yin Xu

The scientist has published extensively in several key venues, among which are:

  • Molecular Neurodegeneration
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Clinical Investigation
  • Cell Reports
  • Science Translational Medicine

Best Publications

  • Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

    Robert A Cherny;Craig S Atwood;Michel E Xilinas;Danielle N Gray

  • β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

    Hui Zheng;Minghao Jiang;Myrna E. Trumbauer;Dalip J.S. Sirinathsinghji

  • Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor

    Yuxiang Sun;Pei Wang;Hui Zheng;Roy G. Smith

  • NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

    Hong Lian;Li Yang;Allysa Cole;Lu Sun

  • Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

    Hong Lian;Alexandra Litvinchuk;Angie C.-A. Chiang;Nadia Aithmitti

  • Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease

    Ethan R. Roy;Baiping Wang;Ying-Wooi Wan;Gabriel S. Chiu

  • The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective.

    Heidi Martini-Stoica;Yin Xu;Andrea Ballabio;Hui Zheng

  • Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

    Alexandra Litvinchuk;Ying Wooi Wan;Dan B. Swartzlander;Fading Chen

  • Practical considerations for choosing a mouse model of Alzheimer's disease.

    Joanna L. Jankowsky;Hui Zheng

  • Biology and pathophysiology of the amyloid precursor protein

    Hui Zheng;Edward H Koo

  • Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

    Vinicia A. Polito;Hongmei Li;Heidi Martini-Stoica;Baiping Wang

  • Physiological Functions of APP Family Proteins

    Ulrike C. Müller;Hui Zheng

  • Defective Neuromuscular Synapses in Mice Lacking Amyloid Precursor Protein (APP) and APP-Like Protein 2

    Pei Wang;Guang Yang;Dennis R. Mosier;Dennis R. Mosier;Paul Chang

  • Accelerated plaque accumulation, associative learning deficits and up-regulation of α7 nicotinic receptor protein in transgenic mice co-expressing mutant human presenilin 1 and amyloid precursor proteins

    Kelly T. Dineley;Xuefeng Xia;Duy Bui;J. David Sweatt

  • Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Aβ42 production

    Tobias Moehlmann;Edith Winkler;Xuefeng Xia;Dieter Edbauer

  • Presenilin couples the paired phosphorylation of β-catenin independent of axin: Implications for β-catenin activation in tumorigenesis

    David E. Kang;Salvador Soriano;Xuefeng Xia;Charles G. Eberhart

  • Loss of presenilin 1 is associated with enhanced β-catenin signaling and skin tumorigenesis

    Xuefeng Xia;Su Qian;Salvador Soriano;Ying Wu

  • Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.

    Ying-Wooi Wan;Ying-Wooi Wan;Rami Al-Ouran;Rami Al-Ouran;Carl G. Mangleburg;Carl G. Mangleburg;Thanneer M. Perumal

  • Presynaptic and Postsynaptic Interaction of the Amyloid Precursor Protein Promotes Peripheral and Central Synaptogenesis

    Zilai Wang;Baiping Wang;Li Yang;Qinxi Guo

  • Genomic DNA microextraction: A method to screen numerous samples

    Ramiro Ramirez-Solis;Jaime A. Rivera-Pérez;James D. Wallace;Marie Wims

  • Presenilin 1 Negatively Regulates β-Catenin/T Cell Factor/Lymphoid Enhancer Factor-1 Signaling Independently of β-Amyloid Precursor Protein and Notch Processing

    Salvador Soriano;David E. Kang;Maofu Fu;Richard Pestell

Frequent Co-Authors

Huaxi Xu
Huaxi Xu Xiamen University
Todd E. Golde
Todd E. Golde Emory University
Andrea Ballabio
Andrea Ballabio Baylor College of Medicine
Allan Bradley
Allan Bradley University of Cambridge
Joshua M. Shulman
Joshua M. Shulman Baylor College of Medicine
Virginia M.-Y. Lee
Virginia M.-Y. Lee University of Pennsylvania
Kelly T. Dineley
Kelly T. Dineley The University of Texas Medical Branch at Galveston
Michelle E. Ehrlich
Michelle E. Ehrlich Icahn School of Medicine at Mount Sinai
Gareth R. Howell
Gareth R. Howell The Jackson Laboratory

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