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Genetics
UK
2024
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Genetics and Molecular Biology
UK
2024

D-Index & Metrics

Genetics

D-Index
146
Citations
106955
World Ranking
153
National Ranking
28

Medicine

D-Index
147
Citations
108273
World Ranking
1256
National Ranking
131

Research.com Recognitions

  • 2024 - Research.com Genetics in United Kingdom Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in United Kingdom Leader Award
  • 2023 - Research.com Genetics in United Kingdom Leader Award
  • 2002 - Fellow of the Royal Society, United Kingdom

Overview

Allan Bradley is affiliated with the University of Cambridge in the United Kingdom and has contributed extensively to the fields of biochemistry, genetics, and molecular biology, with additional work in medicine. Their research spans several subfields including molecular biology, genetics, cancer research, immunology, and epidemiology.

The scientist's work addresses multiple main topics such as CRISPR and genetic engineering, RNA and protein synthesis mechanisms, microRNA in disease regulation, cancer genomics and diagnostics, RNA modifications and cancer, genomics and chromatin dynamics, and adenosine and purinergic signaling.

Some frequent publication venues include bioRxiv (Cold Spring Harbor Laboratory), Genome Biology, Cell, Scientific Reports, and Molecular Cell.

Recent papers from Allan Bradley provide insight into various aspects of molecular biology and genetics:

  • METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation (2021), published in Molecular Cell
  • A resource of targeted mutant mouse lines for 5,061 genes (2021), published in Nature Genetics
  • Cas9-induced large deletions and small indels are controlled in a convergent fashion (2022), published in Nature Communications
  • FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle (2020), published in Cell
  • miR-200 deficiency promotes lung cancer metastasis by activating Notch signaling in cancer-associated fibroblasts (2021), published in Genes & Development

The scientist has collaborated frequently with several coauthors, including George S. Vassiliou, David J. Adams, Steve D. M. Brown, Brendan Doe, and Yann Hérault.

In recognition of their contributions, Allan Bradley was named a Fellow of the Royal Society, United Kingdom, in 2002.

Best Publications

  • Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

    Lawrence A. Donehower;Michele Harvey;Betty L. Slagle;Mark J. McArthur

  • Identification of Mammalian microRNA Host Genes and Transcription Units

    Antony Rodriguez;Sam Griffiths-Jones;Jennifer L. Ashurst;Allan Bradley

  • Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice

    Philipps Soriano;Charles Montgomery;Robert Geske;Allan Bradley

  • p63 is a p53 homologue required for limb and epidermal morphogenesis.

    Alea A. Mills;Binhai Zheng;Xiao-Jing Wang;Hannes Vogel

  • Requirement of bic/microRNA-155 for normal immune function.

    Antony Rodriguez;Elena Vigorito;Simon Clare;Madhuri V. Warren;Madhuri V. Warren

  • Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines

    Allan Bradley;Martin Evans;Matthew H. Kaufman;Elizabeth Robertson

  • Multiple defects of immune cell function in mice with disrupted interferon-gamma genes

    Dyana K. Dalton;Sharon Pitts-Meek;Satish Keshav;Irene S. Figari

  • Chk1 is an essential kinase that is regulated by Atr and required for the G2/M DNA damage checkpoint

    Qinghua Liu;Saritha Guntuku;Xian Shu Cui;Shuhei Matsuoka

  • Increased bone formation in osteocalcin-deficient mice

    Patricia Ducy;Christelle Desbois;Brendan Boyce;Gerald Pinero

  • The Wnt-1 (int-1) proto-oncogene is required for development of a large region of the mouse brain

    Andrew P. McMahon;Allan Bradley

  • A conditional knockout resource for the genome-wide study of mouse gene function.

    William C. Skarnes;Barry Rosen;Anthony P. West;Manousos Koutsourakis

  • p53 mutant mice that display early ageing-associated phenotypes

    Stuart D. Tyner;Sundaresan Venkatachalam;Jene Choi;Stephen Jones

  • Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

    Paul Hasty;Paul Hasty;Allan Bradley;Julia H. Morris;Diane G. Edmondson

  • Repair of double-strand breaks induced by CRISPR–Cas9 leads to large deletions and complex rearrangements

    Michael Kosicki;Kärt Tomberg;Allan Bradley

  • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

    Stephen N. Jones;Amy E. Roe;Lawrence A. Donehower;Allan Bradley

  • Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis.

    Eva Y.-H. P. Lee;Chi-Yao Chang;Nanpin Hu;Yi-Chun J. Wang

  • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

    Shyam K. Sharan;Masami Morimatsu;Masami Morimatsu;Urs Albrecht;Dae Sik Lim

  • Impaired energy homeostasis in C/EBP alpha knockout mice.

    Nai-dy Wang;Milton J. Finegold;Allan Bradley;Ching N. Ou

  • P53-independent expression of p21Cip1 in muscle and other terminally differentiating cells

    S. B. Parker;G. Eichele;Pumin Zhang;A. Rawls

  • BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

    Guangbin Luo;C. Hofmann;A. L. J. J. Bronckers;M. Sohocki

Frequent Co-Authors

Roland Rad
Roland Rad Technical University of Munich
David J. Adams
David J. Adams Wellcome Sanger Institute
Lawrence A. Donehower
Lawrence A. Donehower Baylor College of Medicine
George S. Vassiliou
George S. Vassiliou University of Cambridge
Pentao Liu
Pentao Liu University of Hong Kong
Paul Hasty
Paul Hasty The University of Texas Health Science Center at San Antonio
Wei Wang
Wei Wang Harbin Institute of Technology
Kosuke Yusa
Kosuke Yusa Kyoto University
Binhai Zheng
Binhai Zheng University of California, San Diego
Hannes Vogel
Hannes Vogel Stanford University

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