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Molecular Biology

D-Index
52
Citations
13418
World Ranking
2416
National Ranking
1192

Overview

Paul Hasty is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research predominantly lies within the field of Biochemistry, Genetics and Molecular Biology, with notable contributions in Molecular Biology, Genetics, Oncology, Cancer Research, and Pathology and Forensic Medicine.

The scientist has explored multiple key topics in their work, including:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Digestive system and related health
  • PI3K/AKT/mTOR signaling in cancer
  • PARP inhibition in cancer therapy
  • Genetic factors in colorectal cancer
  • Telomeres, Telomerase, and Senescence

Noteworthy recent publications by Paul Hasty cover a range of subjects in cancer biology and aging, including:

  • Rapamycin Extends Life Span in Apc Colon Cancer FAP Model (2020), published in Clinical Colorectal Cancer
  • Persistent NF-κB activation in muscle stem cells induces proliferation-independent telomere shortening (2021), published in Cell Reports
  • Acarbose improved survival for Apc+/Min mice (2020), published in Aging Cell
  • Musashi1 Contribution to Glioblastoma Development via Regulation of a Network of DNA Replication, Cell Cycle and Division Genes (2021), published in Cancers
  • Sex-dependent lifespan extension of ApcMin/+ FAP mice by chronic mTOR inhibition (2020), published in Aging Pathobiology and Therapeutics

The scientist frequently publishes in several peer-reviewed venues including Cell Reports, Clinical Colorectal Cancer, Aging Cell, Cancers, and Aging Pathobiology and Therapeutics.

Paul Hasty collaborates regularly with several co-authors, indicating a collaborative research approach. Frequent collaborators include Sherry G. Dodds, Manish Parihar, Z. Dave Sharp, Mi-Young Son, and Gene B. Hubbard.

Best Publications

  • Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene

    Paul Hasty;Paul Hasty;Allan Bradley;Julia H. Morris;Diane G. Edmondson

  • Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2

    Shyam K. Sharan;Masami Morimatsu;Masami Morimatsu;Urs Albrecht;Dae Sik Lim

  • A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53.

    Dae Sik Lim;Paul Hasty

  • Aging and Genome Maintenance: Lessons from the Mouse?

    Paul Hasty;Judith Campisi;Judith Campisi;Jan Hoeijmakers;Harry van Steeg

  • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates

    Chengming Zhu;Molly A. Bogue;Dae Sik Lim;Paul Hasty

  • Introduction of a subtle mutation into the hox-2.6 locus in embryonic stem cells

    Paul Hasty;Ramiro Ramírez-Solis;Robb Krumlauf;Allan Bradley

  • Deletion of Ku86 causes early onset of senescence in mice.

    Hannes Vogel;Dae Sik Lim;Gerard Karsenty;Milton Finegold

  • The length of homology required for gene targeting in embryonic stem cells.

    Paul Hasty;Jaime A. Rivera-Pérez;Allan Bradley

  • ERCC1-XPF Endonuclease Facilitates DNA Double-Strand Break Repair

    Anwaar Ahmad;Andria Rasile Robinson;Anette Duensing;Ellen van Drunen

  • Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells.

    Paul Hasty;Jaime A. Rivera-Pérez;Christine Chang;Allan Bradley

  • Defective embryonic neurogenesis in Ku-deficient but not DNA-dependent protein kinase catalytic subunit-deficient mice.

    Yansong Gu;JoAnn Sekiguchi;Yijie Gao;Pieter Dikkes

  • Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

    Steven A. Roberts;Natasha Strande;Martin D. Burkhalter;Christina Strom

  • Methods for the genetic modification of endogenous genes in animal cells by homologous recombination

    Allan Bradley;Ann Davis;Paul Hasty

  • Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53

    Dae Sik Lim;Hannes Vogel;Dennis M. Willerford;Arthur T. Sands

  • Targeted Mutation in β1,4-Galactosyltransferase Leads to Pituitary Insufficiency and Neonatal Lethality

    Qingxian Lu;Paul Hasty;Barry D. Shur

  • The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.

    E M Bahassi;J L Ovesen;A L Riesenberg;W Z Bernstein

  • Targeting frequency for deletion vectors in embryonic stem cells.

    Hongbing Zhang;Paul Hasty;Allan Bradley

  • Modifying the mouse: design and desire.

    Allan Bradley;Paul Hasty;Ann Davis;Ramiro Ramirez-Solis

  • Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer

    Han Li;Hannes Vogel;Valerie B. Holcomb;Yansong Gu

  • A severe phenotype in mice with a duplication of exon 3 in the cystic fibrosis locus

    Wanda K. O'Neal;Paul Hasty;Paul B. McCray Jr.;Brett Casey

Frequent Co-Authors

Allan Bradley
Allan Bradley University of Cambridge
Jan Vijg
Jan Vijg Albert Einstein College of Medicine
Judith Campisi
Judith Campisi Buck Institute for Research on Aging
Tyler J. Curiel
Tyler J. Curiel The University of Texas at San Antonio
Hannes Vogel
Hannes Vogel Stanford University
Jan H.J. Hoeijmakers
Jan H.J. Hoeijmakers Erasmus University Rotterdam
Dae-Sik Lim
Dae-Sik Lim Korea Advanced Institute of Science and Technology
Yang Liu
Yang Liu University of Michigan–Ann Arbor
Martin A. Javors
Martin A. Javors The University of Texas Health Science Center at San Antonio
Frank L. Graham
Frank L. Graham McMaster University

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