World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
72
Citations
21810
World Ranking
1311
National Ranking
9

Research.com Recognitions

  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Fellow of The Academy of Medical Sciences, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Ashok R. Venkitaraman is primarily affiliated with the Agency for Science, Technology and Research in Singapore. Their research spans extensive areas within biochemistry, genetics, and molecular biology, with a notable focus on cancer-related studies and cellular mechanisms.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Within these broader domains, the subfields of study frequently addressed in their work are:

  • Molecular Biology
  • Oncology
  • Cell Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine

The research topics covered by Ashok R. Venkitaraman include:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Cancer-related Molecular Pathways
  • RNA modifications and cancer
  • PARP inhibition in cancer therapy
  • Ubiquitin and proteasome pathways
  • Ferroptosis and cancer prognosis

The scientist has published extensively in several venues, with the most frequent publication outlets being:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Cell Reports
  • Nucleic Acids Research
  • Cell chemical biology

Recent notable papers authored or co-authored by Ashok R. Venkitaraman include:

  • "A glycolytic metabolite bypasses "two-hit" tumor suppression by BRCA2", 2024, Cell
  • "Ketogenic diet promotes tumor ferroptosis but induces relative corticosterone deficiency that accelerates cachexia", 2023, Cell Metabolism
  • "Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity", 2022, Proceedings of the National Academy of Sciences
  • "A small-molecule inhibitor of the BRCA2-RAD51 interaction modulates RAD51 assembly and potentiates DNA damage-induced cell death", 2021, Cell chemical biology
  • "Pulsatile MAPK Signaling Modulates p53 Activity to Control Cell Fate Decisions at the G2 Checkpoint for DNA Damage", 2020, Cell Reports

Frequent co-authors collaborating with Ashok R. Venkitaraman include:

  • Alessandro Esposito
  • Li Kong
  • Grahame J. McKenzie
  • Marko Hyvönen
  • Miriam Ferrer

Ashok R. Venkitaraman has received distinctions including membership in the European Molecular Biology Organization (EMBO) and has been recognized as a Fellow of The Academy of Medical Sciences, United Kingdom.

Best Publications

  • Cancer Susceptibility and the Functions of BRCA1 and BRCA2

    Ashok R. Venkitaraman

  • AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol.

    Shubha Anand;Sue Penrhyn-Lowe;Ashok R Venkitaraman

  • Role of BRCA2 in control of the RAD51 recombination and DNA repair protein.

    Adelina A Davies;Jean-Yves Masson;Michael J McIlwraith;Alicja Z Stasiak

  • Insights into DNA recombination from the structure of a RAD51-BRCA2 complex

    Luca Pellegrini;David S. Yu;Thomas Lo;Shubha Anand

  • Involvement of Brca2 in DNA repair.

    Ketan J Patel;Veronica P.C.C Yu;Hyunsook Lee;Anne Corcoran

  • EMSY Links the BRCA2 Pathway to Sporadic Breast and Ovarian Cancer

    Luke Hughes-Davies;David Huntsman;Margarida Ruas;Francois Fuks

  • HP1-β mobilization promotes chromatin changes that initiate the DNA damage response

    Nabieh Ayoub;Anand D. Jeyasekharan;Juan A. Bernal;Ashok R. Venkitaraman

  • A Conserved Quadruplex Motif Located in a Transcription Activation Site of the Human c-kit Oncogene

    Himesh Fernando;Anthony P. Reszka;Julian Huppert;Sylvain Ladame

  • Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

    Anne E. Corcoran;Andrew Riddell;Danielle Krooshoop;Ashok R. Venkitaraman

  • The B-cell antigen receptor of the five immunoglobulin classes

    Ashok R. Venkitaraman;Gareth T. Williams;Piona Dariavach;Piona Dariavach;Michael S. Neuberger

  • Gross chromosomal rearrangements and genetic exchange between nonhomologous chromosomes following BRCA2 inactivation

    Veronica P.C.C. Yu;Michael Koehler;Claus Steinlein;Michael Schmid

  • The GDI-like solubilizing factor PDEδ sustains the spatial organization and signalling of Ras family proteins

    Anchal Chandra;Hernãin E. Grecco;Venkat Pisupati;David Perera

  • Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2.

    Matthew J. Daniels;Yunmei Wang;MiYoung Lee;Ashok R. Venkitaraman

  • Stabilization of stalled DNA replication forks by the BRCA2 breast cancer susceptibility protein

    Mikhail Lomonosov;Shubha Anand;Mahesh Sangrithi;Rachel Davies

  • Initiation of DNA replication requires the RECQL4 protein mutated in Rothmund-Thomson syndrome.

    Mahesh N. Sangrithi;Juan A. Bernal;Juan A. Bernal;Mark Madine;Anna Philpott

  • Full‐length archaeal Rad51 structure and mutants: mechanisms for RAD51 assembly and control by BRCA2

    David S. Shin;Luca Pellegrini;Douglas S. Daniels;Biana Yelent

  • Cancer Suppression by the Chromosome Custodians, BRCA1 and BRCA2

    Ashok R. Venkitaraman

  • Functions of BRCA1 and BRCA2 in the biological response to DNA damage.

    Ashok R. Venkitaraman

  • The BRC Repeats of BRCA2 Modulate the DNA Binding Selectivity of RAD51

    Aura Carreira;Jovencio Hilario;Ichiro Amitani;Ronald J. Baskin

  • Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors.

    Caroline Pallard;Alexander P.A Stegmann;Titia van Kleffens;Fiona Smart

Frequent Co-Authors

David R. Spring
David R. Spring University of Cambridge
Tom L. Blundell
Tom L. Blundell University of Cambridge
Jernej Ule
Jernej Ule The Francis Crick Institute
Chandra S. Verma
Chandra S. Verma Agency for Science, Technology and Research
Mike C. Payne
Mike C. Payne University of Cambridge
Chris-Kriton Skylaris
Chris-Kriton Skylaris University of Southampton
Chris Abell
Chris Abell University of Cambridge
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute
Bruce A.J. Ponder
Bruce A.J. Ponder University of Cambridge

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