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Chemistry

D-Index
71
Citations
21738
World Ranking
5458
National Ranking
315

Research.com Recognitions

  • 2014 - Corday–Morgan Prize, Royal Society of Chemistry (UK)

Overview

David R. Spring is affiliated with the University of Cambridge in the United Kingdom. Their research encompasses various areas within biochemistry, genetics, and molecular biology, with a particular emphasis on molecular biology, oncology, organic chemistry, materials chemistry, and radiology, nuclear medicine, and imaging.

Their scholarly output includes a range of peer-reviewed papers, with notable recent publications such as:

  • "The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions", 2021, Chemical Society Reviews
  • "Site-selective modification strategies in antibody-drug conjugates", 2020, Chemical Society Reviews
  • "Peptides as a platform for targeted therapeutics for cancer: peptide-drug conjugates (PDCs)", 2020, Chemical Society Reviews
  • "Photocatalytic methods for amino acid modification", 2020, Chemical Society Reviews
  • "Non-internalising antibody-drug conjugates", 2022, Chemical Society Reviews

Frequent co-authors collaborating with Spring include:

  • Stephen J. Walsh
  • Jason S. Carroll (20 joint publications)
  • Hannah F. Sore (15 joint publications)
  • Marko Hyvönen (12 joint publications)
  • Laura S. Itzhaki (12 joint publications)

The scientist regularly publishes in several academic venues, prominently featuring:

  • Chemical Communications (13 publications)
  • The Cambridge Structural Database (10 publications)
  • Chemical Science (9 publications)
  • Chemical Society Reviews (8 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)

Main topics of research and publication include:

  • Chemical Synthesis and Analysis
  • Click Chemistry and Applications
  • Monoclonal and Polyclonal Antibodies Research
  • HER2/EGFR in Cancer Research
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Microbial Natural Products and Biosynthesis

David R. Spring was awarded the Corday-Morgan Prize by the Royal Society of Chemistry (UK) in 2014.

Best Publications

  • Fluorescent chemosensors for Zn2

    Zhaochao Xu;Juyoung Yoon;David R. Spring

  • Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules

    Warren R J D Galloway;Albert Isidro-Llobet;David R Spring

  • Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.

    Warren R. J. D. Galloway;James T. Hodgkinson;Steven D. Bowden;Martin Welch

  • Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor.

    Zhaochao Xu;Zhaochao Xu;Kyung Hwa Baek;Ha Na Kim;Jingnan Cui

  • Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy

    Fengzhi Zhang;Fengzhi Zhang;David R. Spring

  • Peptide stapling techniques based on different macrocyclisation chemistries

    Yu Heng Lau;Peterson de Andrade;Yuteng Wu;David R. Spring

  • Cleavable linkers in antibody-drug conjugates.

    Jonathan D Bargh;Albert Isidro-Llobet;Jeremy S Parker;David R Spring

  • Diversity-oriented synthesis: producing chemical tools for dissecting biology

    Cornelius J. O' Connor;Henning S. G. Beckmann;David R. Spring

  • Diversity-oriented synthesis; a challenge for synthetic chemists

    David R. Spring

  • The molecular basis of the host response to lipopolysaccharide

    Clare E. Bryant;David R. Spring;Monique Gangloff

  • Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

    Kieron M. G. O'Connell;James T. Hodgkinson;Hannah F. Sore;Martin Welch

  • The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions.

    Bee Ha Gan;Josephine Gaynord;Sam M Rowe;Tomas Deingruber

  • Palladium-catalysed cross-coupling of organosilicon reagents

    Hannah F. Sore;Warren R. J. D. Galloway;David R. Spring

  • Site-selective modification strategies in antibody-drug conjugates.

    Stephen J Walsh;Jonathan D Bargh;Friederike M Dannheim;Abigail R Hanby

  • Chemical genetics to chemical genomics: small molecules offer big insights.

    David R. Spring

  • Diversity-oriented synthesis; a spectrum of approaches and results

    Richard J. Spandl;Andreas Bender;David R. Spring

  • Peptides as a platform for targeted therapeutics for cancer: peptide–drug conjugates (PDCs)

    Bethany M Cooper;Jessica Iegre;Daniel H O' Donovan;Maria Ölwegård Halvarsson

  • A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells.

    Tianyu Liu;Zhaochao Xu;David R. Spring;Jingnan Cui

  • Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips

    Jing Huang;Heng Zhu;Stephen J. Haggarty;David R. Spring;David R. Spring

  • A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching.

    Zhaochao Xu;Zhaochao Xu;Juyoung Yoon;David R. Spring

  • Coumarin-derived transformable fluorescent sensor for Zn2+.

    Zhaochao Xu;Xin Liu;Jie Pan;David R. Spring

Frequent Co-Authors

Ashok R. Venkitaraman
Ashok R. Venkitaraman Agency for Science, Technology and Research
Zhaochao Xu
Zhaochao Xu Dalian Institute of Chemical Physics
Chandra S. Verma
Chandra S. Verma Agency for Science, Technology and Research
Andreas Bender
Andreas Bender University of Cambridge
George P. C. Salmond
George P. C. Salmond University of Cambridge
Juyoung Yoon
Juyoung Yoon Ewha Womans University
Jack E. Baldwin
Jack E. Baldwin University of Oxford
Chris Abell
Chris Abell University of Cambridge
Jason S. Carroll
Jason S. Carroll University of Cambridge
Stuart L. Schreiber
Stuart L. Schreiber Harvard University

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