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Molecular Biology

D-Index
110
Citations
39211
World Ranking
379
National Ranking
218

Overview

Patrick Sung is affiliated with The University of Texas Health Science Center at San Antonio in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a total of 157 publications in these areas. Medicine is a secondary field with 56 publications. The subfields of study include molecular biology, oncology, cancer research, genetics, and immunology.

The scientist's work covers a range of topics, notably:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • PARP inhibition in cancer therapy
  • RNA modifications and cancer
  • RNA Research and Splicing
  • Telomeres, Telomerase, and Senescence
  • Genomics and Chromatin Dynamics

Frequent publication venues for their work include:

  • Journal of Biological Chemistry (21 publications)
  • Molecular Cell (7 publications)
  • Nature Communications (7 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (7 publications)
  • Cancer Research (6 publications)

Patrick Sung has collaborated frequently with several researchers, including Youngho Kwon, Sandeep Burma, Weixing Zhao, Eric C. Greene, and Robert Hromas.

Some notable recent papers by Patrick Sung include:

  • The antitumorigenic roles of BRCA1-BARD1 in DNA repair and replication, 2020, Nature Reviews Molecular Cell Biology
  • UAP56/DDX39B is a major cotranscriptional RNA-DNA helicase that unwinds harmful R loops genome-wide, 2020, Genes & Development
  • The complementarity of DDR, nucleic acids and anti-tumour immunity, 2023, Nature
  • Rad54 Drives ATP Hydrolysis-Dependent DNA Sequence Alignment during Homologous Recombination, 2020, Cell
  • The Rad51 paralog complex Rad55-Rad57 acts as a molecular chaperone during homologous recombination, 2021, Molecular Cell

Best Publications

  • Mechanism of eukaryotic homologous recombination.

    Joseph San Filippo;Patrick Sung;Hannah Klein

  • Catalysis of ATP-dependent homologous DNA pairing and strand exchange by yeast RAD51 protein

    Patrick Sung

  • Mechanism of homologous recombination: mediators and helicases take on regulatory functions

    Patrick Sung;Hannah Klein

  • DNA helicase Srs2 disrupts the Rad51 presynaptic filament

    Lumir Krejci;Stephen Van Komen;Ying Li;Jana Villemain

  • Yeast Rad55 and Rad57 proteins form a heterodimer that functions with replication protein A to promote DNA strand exchange by Rad51 recombinase.

    Patrick Sung

  • Function of Yeast Rad52 Protein as a Mediator between Replication Protein A and the Rad51 Recombinase

    Patrick Sung

  • DNA strand exchange mediated by a RAD51-ssDNA nucleoprotein filament with polarity opposite to that of RecA

    Patrick Sung;Donald L Robberson;Donald L Robberson

  • Crosstalk between SUMO and ubiquitin on PCNA is mediated by recruitment of the helicase Srs2p.

    Efterpi Papouli;Shuhua Chen;Shuhua Chen;Adelina A. Davies;Diana Huttner

  • DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis.

    Gopal K. Dasika;Suh Chin J. Lin;Song Zhao;Patrick Sung

  • Nuclease Activities in a Complex of Human Recombination and DNA Repair Factors Rad50, Mre11, and p95

    Kelly M. Trujillo;Shyng Shiou F. Yuan;Eva Y.H.P. Lee;Patrick Sung

  • Rad51 Recombinase and Recombination Mediators

    Patrick Sung;Lumir Krejci;Stephen Van Komen;Michael G. Sehorn

  • Catalysis of homologous DNA pairing by yeast Rad51 and Rad54 proteins

    Galina Petukhova;Sabrina Stratton;Patrick Sung

  • Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes.

    Ling Chen;Kelly Trujillo;William Ramos;Patrick Sung

  • DNA repair genes and proteins of Saccharomyces cerevisiae

    Satya Prakash;Patrick Sung;Louise Prakash

  • Human xeroderma pigmentosum group D gene encodes a DNA helicase.

    Patrick Sung;Patrick Sung;Véronique Bailly;Véronique Bailly;Christine Weber;Larry H. Thompson

  • Specific complex formation between yeast RAD6 and RAD18 proteins: A potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites

    Véronique Bailly;Véronique Bailly;John Lamb;John Lamb;Patrick Sung;Patrick Sung;Satya Prakash

  • Mechanism of the ATP-dependent DNA end-resection machinery from Saccharomyces cerevisiae

    Hengyao Niu;Woo Hyun Chung;Zhu Zhu;Youngho Kwon

  • RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments.

    Yiduo Hu;Steven Raynard;Michael G. Sehorn;Michael G. Sehorn;Xincheng Lu

  • Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

    Gang Chen;Shyng Shiou F. Yuan;Wei Liu;Yang Xu

  • BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing

    Weixing Zhao;Justin B. Steinfeld;Fengshan Liang;Xiaoyong Chen

Frequent Co-Authors

Louise Prakash
Louise Prakash The University of Texas Medical Branch at Galveston
Satya Prakash
Satya Prakash The University of Texas Medical Branch at Galveston
Eric C. Greene
Eric C. Greene Columbia University
Lumir Krejci
Lumir Krejci Masaryk University
Hannah L. Klein
Hannah L. Klein New York University
Yong Xiong
Yong Xiong Yale University
Robert Hromas
Robert Hromas The University of Texas Health Science Center at San Antonio
Elizabeth A. Williamson
Elizabeth A. Williamson London School of Hygiene & Tropical Medicine
Rodney Rothstein
Rodney Rothstein Columbia University
Michael Lisby
Michael Lisby University of Copenhagen

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