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Alexander V. Mazin

Alexander V. Mazin

D-Index & Metrics

Molecular Biology

D-Index
45
Citations
7436
World Ranking
2864
National Ranking
1366

Overview

Alexander V. Mazin is affiliated with Drexel University in the United States and has contributed extensively to the fields of biochemistry, genetics, and molecular biology. Their research spans multiple subfields including molecular biology, oncology, genetics, plant science, and cell biology.

The scientist's work focuses primarily on DNA repair mechanisms, with significant attention to topics such as PARP inhibition in cancer therapy, CRISPR and genetic engineering, RNA research and splicing, RNA and protein synthesis mechanisms, plant disease resistance and genetics, as well as RNA modifications and cancer.

Alexander V. Mazin has published numerous papers in various scientific venues. Notable recent publications include:

  • DNA binding and RAD51 engagement by the BRCA2 C-terminus orchestrate DNA repair and replication fork preservation (2023), Nature Communications
  • RAD52: Paradigm of Synthetic Lethality and New Developments (2021), Frontiers in Genetics
  • Genetic Characterization of Three Distinct Mechanisms Supporting RNA-Driven DNA Repair and Modification Reveals Major Role of DNA Polymerase ζ (2020), Molecular Cell
  • New RAD51 Inhibitors to Target Homologous Recombination in Human Cells (2021), Genes
  • Replication protein A binds RNA and promotes R-loop formation (2020), Journal of Biological Chemistry

Frequent publication venues for Mazin's research include:

  • Journal of Biological Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Nucleic Acids Research
  • Nature Communications

Their frequent co-authors reflect ongoing collaborations within this field, and include:

  • Olga M. Mazina
  • Youngho Kwon
  • Weixing Zhao
  • Sandeep Burma
  • Robert Hromas

Alexander V. Mazin's research contributes to a deeper understanding of cellular mechanisms in DNA repair and genome stability, critical areas for advancing cancer therapies and genetic technologies. The scientist's extensive publication record and multidisciplinary approach emphasize a broad interest in the molecular basis of genetics and oncology-related challenges.

Best Publications

  • Novel pro- and anti-recombination activities of the Bloom’s syndrome helicase

    Dmitry V. Bugreev;Xiong Yu;Edward H. Egelman;Alexander V. Mazin

  • Transcript-RNA-templated DNA recombination and repair

    Havva Keskin;Ying Shen;Fei Huang;Mikir Patel

  • Ca2+ activates human homologous recombination protein Rad51 by modulating its ATPase activity

    Dmitry V. Bugreev;Alexander V. Mazin

  • Rad54 protein possesses chromatin-remodeling activity stimulated by the Rad51–ssDNA nucleoprotein filament

    Andrei Alexeev;Alexander Mazin;Alexander Mazin;Stephen C. Kowalczykowski

  • Rad54 protein is targeted to pairing loci by the Rad51 nucleoprotein filament.

    Alexander V. Mazin;Carole J. Bornarth;Jachen A. Solinger;Wolf Dietrich Heyer

  • A novel function of Rad54 protein. Stabilization of the Rad51 nucleoprotein filament.

    Alexander V. Mazin;Alexander V. Mazin;Andrei A. Alexeev;Stephen C. Kowalczykowski

  • Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54.

    Nicolas H Thomä;Bryan K Czyzewski;Andrei A Alexeev;Alexander V Mazin

  • Rad54 protein promotes branch migration of Holliday junctions.

    Dmitry V. Bugreev;Olga M. Mazina;Alexander V. Mazin

  • Identification of specific inhibitors of human RAD51 recombinase using high-throughput screening.

    Fei Huang;Nuzhat A. Motlekar;Chelsea M. Burgwin;Andrew D. Napper

  • Rad54, the motor of homologous recombination

    Alexander V. Mazin;Olga M. Mazina;Dmitry V. Bugreev;Matthew J. Rossi

  • Tailed duplex DNA is the preferred substrate for Rad51 protein-mediated homologous pairing

    Alexander V. Mazin;Elena Zaitseva;Patrick Sung;Stephen C. Kowalczykowski

  • Inhibition of homologous recombination in human cells by targeting RAD51 recombinase.

    Fei Huang;Olga M Mazina;Isaac J Zentner;Simon Cocklin

  • Human Rad52 binds and wraps single-stranded DNA and mediates annealing via two hRad52-ssDNA complexes

    Jill M. Grimme;Jill M. Grimme;Masayoshi Honda;Rebecca Wright;Yusuke Okuno

  • Complex formation by the human Rad51B and Rad51C DNA repair proteins and their activities in vitro

    Yi Ching Lio;Alexander V. Mazin;Alexander V. Mazin;Stephen C. Kowalczykowski;David J. Chen

  • A Small Molecule Inhibitor of Human RAD51 Potentiates Breast Cancer Cell Killing by Therapeutic Agents in Mouse Xenografts

    Fei Huang;Alexander V. Mazin

  • The function of the secondary DNA-binding site of RecA protein during DNA strand exchange.

    Alexander V. Mazin;Stephen C. Kowalczykowski

  • FANCJ Uses Its Motor ATPase to Destabilize Protein-DNA Complexes, Unwind Triplexes, and Inhibit RAD51 Strand Exchange

    Joshua A. Sommers;Nina Rawtani;Rigu Gupta;Dmitry V. Bugreev;Dmitry V. Bugreev

  • Saccharomyces cerevisiae Mer3 helicase stimulates 3'-5' heteroduplex extension by Rad51; implications for crossover control in meiotic recombination.

    Olga M Mazina;Olga M Mazina;Alexander V Mazin;Alexander V Mazin;Takuro Nakagawa;Richard D Kolodner

  • Rad54 dissociates homologous recombination intermediates by branch migration

    Dmitry V Bugreev;Fumio Hanaoka;Alexander V Mazin

  • STRUCTURE OF THE SW12/SNF2 CHROMATIN-REMODELING DOMAIN OF EUKARYOTIC RAD54

    N. Thoma;B. Czyzewski;A. Alexeev;A. Mazin

Frequent Co-Authors

Stephen C. Kowalczykowski
Stephen C. Kowalczykowski University of California, Davis
Grigory L. Dianov
Grigory L. Dianov Novosibirsk State University
R. Daniel Camerini-Otero
R. Daniel Camerini-Otero National Institutes of Health
Robert M. Brosh
Robert M. Brosh National Institutes of Health
Tomasz Skorski
Tomasz Skorski Temple University
Nikola P. Pavletich
Nikola P. Pavletich Memorial Sloan Kettering Cancer Center
Bruce E. Clurman
Bruce E. Clurman Fred Hutchinson Cancer Research Center
Robert L. Moritz
Robert L. Moritz Institute for Systems Biology
Markus Müschen
Markus Müschen Yale University
Peter Valent
Peter Valent Medical University of Vienna

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