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Biology and Biochemistry

D-Index
59
Citations
12440
World Ranking
12539
National Ranking
5367

Overview

Tomasz Skorski is affiliated with Temple University in the United States and has contributed extensively to the fields of biochemistry, genetics, molecular biology, and medicine. Their research centers on molecular biology and oncology, with significant work in hematology, genetics, and cancer research. The scientist's main research topics include DNA repair mechanisms, PARP inhibition in cancer therapy, acute myeloid leukemia research, CRISPR and genetic engineering, chronic myeloid leukemia treatments, epigenetics and DNA methylation, and cancer therapeutics and mechanisms.

Skorski's notable recent publications include:

  • Discovery of a small-molecule inhibitor that traps Polθ on DNA and synergizes with PARP inhibitors, 2024, Nature Communications
  • 4-1BBL-containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells, 2022, Blood Advances
  • ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia, 2021, Molecular Cell
  • TET2 and DNMT3A Mutations Exert Divergent Effects on DNA Repair and Sensitivity of Leukemia Cells to PARP Inhibitors, 2021, Cancer Research
  • TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment, 2020, Cell Reports

The venues where Skorski frequently publishes include:

  • Blood
  • Cancer Research
  • Nature Communications
  • Leukemia
  • bioRxiv (Cold Spring Harbor Laboratory)

Frequent collaborators in Skorski's research are:

  • Monika M. Toma
  • Margaret Nieborowska-Skorska
  • Richard T. Pomerantz
  • Umeshkumar Vekariya
  • Katherine Sullivan-Reed

The scientific contributions of Tomasz Skorski are situated primarily at the interface of molecular mechanisms underlying leukemia and cancer therapeutics, focusing notably on the repair pathways of DNA and the effects of mutations relevant to therapy resistance. Their work covers both fundamental aspects of cell cycle regulation in leukemia cells and applied cancer research investigating the sensitivity and resistance mechanisms to PARP inhibitors.

Best Publications

  • Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

    Tomasz Skorski;Alfonso Bellacosa;Margaret Nieborowska‐Skorska;Miroslaw Majewski

  • Selective inhibition of leukemia cell proliferation by BCR-ABL antisense oligodeoxynucleotides

    Cezary Szczylik;Tomasz Skorski;Nicholas C. Nicolaides;Livia Manzella

  • Chronic myeloid leukemia: mechanisms of blastic transformation

    Danilo Perrotti;Catriona Jamieson;John Goldman;Tomasz Skorski

  • Signal Transducer and Activator of Transcription (STAT)5 Activation by BCR/ABL Is Dependent on Intact Src Homology (SH)3 and SH2 Domains of BCR/ABL and Is Required for Leukemogenesis

    Malgorzata Nieborowska-Skorska;Mariusz A. Wasik;Artur Slupianek;Paolo Salomoni

  • Multilevel Dysregulation of STAT3 Activation in Anaplastic Lymphoma Kinase-Positive T/Null-Cell Lymphoma

    Qian Zhang;Puthryaveett N. Raghunath;Liquan Xue;Miroslaw Majewski

  • BCR/ABL regulates mammalian RecA homologs, resulting in drug resistance.

    Artur Slupianek;Christoph Schmutte;Gregory Tombline;Malgorzata Nieborowska-Skorska

  • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance

    Mateusz Koptyra;Rafal Falinski;Rafal Falinski;Rafal Falinski;Michal O. Nowicki;Michal O. Nowicki;Michal O. Nowicki;Tomasz Stoklosa;Tomasz Stoklosa;Tomasz Stoklosa

  • Role of Phosphatidylinositol 3-Kinase-Akt Pathway in Nucleophosmin/Anaplastic Lymphoma Kinase-mediated Lymphomagenesis

    Artur Slupianek;Margaret Nieborowska-Skorska;Grazyna Hoser;Andrea Morrione

  • BCR/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks

    Michal O. Nowicki;Michal O. Nowicki;Rafal Falinski;Rafal Falinski;Mateusz Koptyra;Mateusz Koptyra;Artur Slupianek;Artur Slupianek

  • De novo decorin gene expression suppresses the malignant phenotype in human colon cancer cells

    Manoranjan Santra;Tomasz Skorski;Bruno Calabretta;Edmund C. Lattime

  • The Src family kinase Hck couples BCR/ABL to STAT5 activation in myeloid leukemia cells

    Agata Klejman;Steven J. Schreiner;Malgorzata Nieborowska‐Skorska;Artur Slupianek

  • Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis.

    Artur Slupianek;Grazyna Hoser;Ireneusz Majsterek;Agnieszka Bronisz

  • Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide

    Tomasz Skorski;Malgorzata Nieborowska-Skorska;Nicholas C. Nicolaides;Cezary Szczylik

  • Rac2-MRC-cIII–generated ROS cause genomic instability in chronic myeloid leukemia stem cells and primitive progenitors

    Margaret Nieborowska-Skorska;Piotr K. Kopinski;Regina Ray;Grazyna Hoser

  • Phosphatidylinositol-3 kinase inhibitors enhance the anti-leukemia effect of STI571.

    Agata Klejman;Lori Rushen;Andrea Morrione;Artur Slupianek

  • Oncogenic tyrosine kinases and the dna-damage response

    Tomasz Skorski

  • BCR/ABL regulates response to DNA damage: the role in resistance to genotoxic treatment and in genomic instability.

    Tomasz Skorski

  • Activation of mitochondrial Raf-1 is involved in the antiapoptotic effects of Akt.

    Miroslaw Majewski;Malgorzata Nieborowska-Skorska;Paolo Salomoni;Artur Slupianek

  • TLS/FUS, a pro‐oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL‐mediated leukemogenesis

    Danilo Perrotti;Silvia Bonatti;Rossana Trotta;Robert Martinez

  • BCR/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance. Commentary

    Ravi Bhatia;Mateusz Koptyra;Rafal Falinski;Michal O. Nowicki

Frequent Co-Authors

Janusz Blasiak
Janusz Blasiak University of Łódź
Mariusz A. Wasik
Mariusz A. Wasik University of Pennsylvania
Bruno Calabretta
Bruno Calabretta Thomas Jefferson University
Peter Valent
Peter Valent Medical University of Vienna
Krzysztof Reiss
Krzysztof Reiss Louisiana State University Health Sciences Center New Orleans
Ravi Bhatia
Ravi Bhatia University of Alabama at Birmingham
Paolo Salomoni
Paolo Salomoni German Center for Neurodegenerative Diseases
Markus Müschen
Markus Müschen Yale University
Renato V. Iozzo
Renato V. Iozzo Thomas Jefferson University
Richard Fishel
Richard Fishel The Ohio State University

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