World's Best Scientists 2026 revealed!

D-Index & Metrics

Genetics

D-Index
44
Citations
7490
World Ranking
4262
National Ranking
1839

Overview

Dale Dorsett is affiliated with Saint Louis University in the United States. Their research spans multiple interconnected fields, including molecular biology, immunology, and genetics. The focus of their work often addresses complex biological processes related to immune cell function, genetic syndromes, RNA mechanisms, and chromatin dynamics.

Their recent publications reflect diverse interests across these areas, with papers appearing in prominent scientific journals. Notable publications include:

  • "A Two-Step Process of Effector Programming Governs CD4+ T Cell Fate Determination Induced by Antigenic Activation in the Steady State" (2020, Cell Reports)
  • "Cornelia de Lange syndrome and the Cohesin complex: Abstracts from the 9th Biennial Scientific and Educational Virtual Symposium 2020" (2021, American Journal of Medical Genetics Part A)
  • "This Week in Science" (2020, Science)
  • "Circular RNAs protect male fertility" (2020, Science)
  • "Histone H3.3 mutations alter development" (2020, Science)

The scientist frequently publishes in the journal Science, which accounts for the majority of their papers. Other publication venues include Cell Reports and the American Journal of Medical Genetics Part A.

Dorsett collaborates regularly with several coauthors, who are prominent in related research fields. Key collaborators include:

  • Marc S. Lavine
  • Michael A. Funk
  • Jelena Stajic
  • Pamela J. Hines
  • Caroline Ash

Their research covers a range of main scientific topics, notably:

  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immunotherapy and Immune Responses
  • Genomics and Chromatin Dynamics
  • RNA Research and Splicing
  • Genetic Syndromes and Imprinting
  • Heat shock proteins research

Dale Dorsett's work contributes to understanding the programming of immune cells, the role of non-coding RNAs in fertility, genetic conditions such as Cornelia de Lange syndrome, and how chromatin modifications influence development. Through interdisciplinary approaches, they engage with both basic molecular mechanisms and their implications for disease and immune system function.

Best Publications

  • Mutations in Cohesin Complex Members SMC3 and SMC1A Cause a Mild Variant of Cornelia de Lange Syndrome with Predominant Mental Retardation

    Matthew A. Deardorff;Matthew A. Deardorff;Maninder Kaur;Dinah Yaeger;Abhinav Rampuria

  • Nipped-B, a Drosophila homologue of chromosomal adherins, participates in activation by remote enhancers in the cut and Ultrabithorax genes.

    Robert A. Rollins;Patrick Morcillo;Dale Dorsett;Dale Dorsett

  • Expression of the cut locus in the Drosophila wing margin is required for cell type specification and is regulated by a distant enhancer

    J. Jack;D. Dorsett;Y. Delotto;S. Liu

  • Drosophila nipped-B protein supports sister chromatid cohesion and opposes the stromalin/Scc3 cohesion factor to facilitate long-range activation of the cut gene.

    Robert A. Rollins;Maria Korom;Nathalie Aulner;Andrew Martens

  • Association of cohesin and Nipped-B with transcriptionally active regions of the Drosophila melanogaster genome.

    Ziva Misulovin;Yuri B. Schwartz;Xiao-Yong Li;Tatyana G. Kahn

  • Distant liaisons: long-range enhancer-promoter interactions in Drosophila.

    Dale Dorsett

  • Chip, a widely expressed chromosomal protein required for segmentation and activity of a remote wing margin enhancer in Drosophila

    Patrick Morcillo;Christina Rosen;Mary K. Baylies;Dale Dorsett

  • Repression of hsp70 heat shock gene transcription by the suppressor of hairy-wing protein of Drosophila melanogaster.

    C Holdridge;D Dorsett

  • Cohesin: genomic insights into controlling gene transcription and development.

    Dale Dorsett

  • Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

    Ryan Rickels;Hans Martin Herz;Christie C. Sze;Kaixiang Cao

  • Roles of the sister chromatid cohesion apparatus in gene expression, development, and human syndromes

    Dale Dorsett

  • Effects of sister chromatid cohesion proteins on cut gene expression during wing development in Drosophila.

    Dale Dorsett;Joel C. Eissenberg;Ziva Misulovin;Andrew Martens

  • The Ancient and Evolving Roles of Cohesin in Gene Expression and DNA Repair

    Dale Dorsett;Lena Ström

  • Insulation of Enhancer-Promoter Communication by a Gypsy Transposon Insert in the Drosophila cut Gene: Cooperation between Suppressor of Hairy-wing and Modifier of mdg4 Proteins

    Maria Gause;Patrick Morcillo;Dale Dorsett;Dale Dorsett

  • On the Molecular Etiology of Cornelia de Lange Syndrome

    Dale Dorsett;Ian D. Krantz

  • Germline gain-of-function mutations in AFF4 cause a developmental syndrome functionally linking the super elongation complex and cohesin

    Kosuke Izumi;Ryuichiro Nakato;Zhe Zhang;Andrew C. Edmondson

  • Metazoan Scc4 homologs link sister chromatid cohesion to cell and axon migration guidance

    Vlad C Seitan;Peter Banks;Steve Laval;Nazia A Majid

  • Positive regulation of c-Myc by cohesin is direct, and evolutionarily conserved

    Jenny M. Rhodes;Fiona K. Bentley;Cristin G. Print;Dale Dorsett

  • Cohesin at active genes: a unifying theme for cohesin and gene expression from model organisms to humans

    Dale Dorsett;Matthias Merkenschlager

  • Cohesin and Polycomb Proteins Functionally Interact to Control Transcription at Silenced and Active Genes

    Cheri A. Schaaf;Ziva Misulovin;Maria Gause;Amanda Koenig

Frequent Co-Authors

Ian D. Krantz
Ian D. Krantz Children's Hospital of Philadelphia
Matthew A. Deardorff
Matthew A. Deardorff Children's Hospital of Philadelphia
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Joel C. Eissenberg
Joel C. Eissenberg Saint Louis University
Jennifer L. Gerton
Jennifer L. Gerton Stowers Institute for Medical Research
Ali Shilatifard
Ali Shilatifard Northwestern University
Kyoko Yokomori
Kyoko Yokomori University of California, Irvine
Alessandro Vindigni
Alessandro Vindigni Washington University in St. Louis
Michael B. Eisen
Michael B. Eisen University of California, Berkeley
Yanjiao Zhou
Yanjiao Zhou University of Connecticut Health Center

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