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Genetics

D-Index
72
Citations
20618
World Ranking
2113
National Ranking
959

Research.com Recognitions

  • 2010 - Member of the National Academy of Sciences
  • 2008 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2000 - Fellow of the American Academy of Arts and Sciences

Overview

Douglas Koshland is a researcher affiliated with the University of California, Berkeley in the United States. Their work primarily spans the fields of biochemistry, genetics, and molecular biology, with significant contributions to agricultural and biological sciences.

Their research focuses on several interconnected topics, including:

  • Genomics and Chromatin Dynamics
  • Chromosomal and Genetic Variations
  • RNA Research and Splicing
  • Plant Molecular Biology Research
  • DNA Repair Mechanisms
  • Microtubule and Mitosis Dynamics
  • Ubiquitin and Proteasome Pathways

Koshland has published extensively in molecular biology and related subfields such as plant science and cell biology. The main subfields represented in their publications are:

  • Molecular Biology
  • Plant Science
  • Cell Biology

Their recent papers demonstrate active involvement in chromatin structure and chromosome dynamics research. Notable publications include:

  • "Cohesin residency determines chromatin loop patterns," 2020, published in eLife
  • "The spatial regulation of condensin activity in chromosome condensation," 2020, published in Genes & Development
  • "Cohesin residency determines chromatin loop patterns," 2020, bioRxiv (Cold Spring Harbor Laboratory)
  • "A model for Scc2p stimulation of cohesin's ATPase and its inhibition by acetylation of Smc3p," 2023, published in Genes & Development
  • "A model for Scc2p Stimulation of Cohesin's ATPase and its Inhibition by Acetylation of Smc3p," 2022, bioRxiv (Cold Spring Harbor Laboratory)

The primary venues for Koshland's scholarly output include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Genes & Development
  • eLife
  • Genetics
  • Cell

Frequent collaborators in their work are:

  • Lorenzo Costantino
  • Siheng Xiang
  • Rebecca Lamothe
  • Kevin Boardman
  • Tsung-Han S. Hsieh

Koshland's career includes recognition by scientific organizations through these awards:

  • Member of the National Academy of Sciences (2010)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2008)
  • Fellow of the American Academy of Arts and Sciences (2000)

Best Publications

  • A Direct Link between Sister Chromatid Cohesion and Chromosome Condensation Revealed through the Analysis of MCD1 in S. cerevisiae

    Vincent Guacci;Douglas Koshland;Alexander Strunnikov

  • Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p.

    O Cohen-Fix;J M Peters;M W Kirschner;D Koshland

  • DNA Damage Response Pathway Uses Histone Modification to Assemble a Double-Strand Break-Specific Cohesin Domain

    Elçin Ünal;Ayelet Arbel-Eden;Ulrike Sattler;Robert Shroff

  • Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

    Pamela B. Meluh;Douglas Koshland

  • Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery

    Robert V. Skibbens;Laura B. Corson;Doug Koshland;Philip Hieter

  • Cse4p Is a Component of the Core Centromere of Saccharomyces cerevisiae

    Pamela B Meluh;Peirong Yang;Lynn Glowczewski;Douglas Koshland

  • A molecular determinant for the establishment of sister chromatid cohesion.

    Elçin Ünal;Jill M. Heidinger-Pauli;Jill M. Heidinger-Pauli;Woong Kim;Vincent Guacci

  • Genome-wide mapping of the cohesin complex in the yeast Saccharomyces cerevisiae.

    Earl F Glynn;Paul C Megee;Hong-Guo Yu;Cathy Mistrot

  • RNase H and Multiple RNA Biogenesis Factors Cooperate to Prevent RNA:DNA Hybrids from Generating Genome Instability

    Lamia Wahba;Jeremy D. Amon;Douglas Koshland;Douglas Koshland;Douglas Koshland;Milena Vuica-Ross

  • Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s).

    A Yamamoto;V Guacci;D Koshland

  • SMC2, a Saccharomyces cerevisiae gene essential for chromosome segregation and condensation, defines a subgroup within the SMC family.

    A V Strunnikov;E Hogan;D Koshland

  • Chromosome condensation and sister chromatid pairing in budding yeast.

    V Guacci;E Hogan;D Koshland

  • MITOTIC CHROMOSOME CONDENSATION

    Douglas Koshland;Alexander Strunnikov

  • Secretion of beta-lactamase requires the carboxy end of the protein

    Douglas Koshland;David Botstein

  • Tardigrades Use Intrinsically Disordered Proteins to Survive Desiccation

    Thomas C. Boothby;Hugo Tapia;Alexandra H. Brozena;Samantha Piszkiewicz

  • Role of astral microtubules and actin in spindle orientation and migration in the budding yeast, Saccharomyces cerevisiae.

    R E Palmer;D S Sullivan;T Huffaker;D Koshland

  • SMC1: an essential yeast gene encoding a putative head-rod-tail protein is required for nuclear division and defines a new ubiquitous protein family.

    A V Strunnikov;V L Larionov;D Koshland

  • Genetic analysis of the mitotic transmission of minichromosomes

    Douglas Koshland;John C. Kent;Leland H. Hartwell

  • Pds5p Is an Essential Chromosomal Protein Required for Both Sister Chromatid Cohesion and Condensation in Saccharomyces cerevisiae

    Theresa Hartman;Kristen Stead;Douglas Koshland;Vincent Guacci

  • DNA Double-Strand Breaks Trigger Genome-Wide Sister-Chromatid Cohesion Through Eco1 (Ctf7)

    Elçin Ünal;Jill M. Heidinger-Pauli;Jill M. Heidinger-Pauli;Douglas Koshland;Douglas Koshland

Frequent Co-Authors

Leland H. Hartwell
Leland H. Hartwell Arizona State University
David Botstein
David Botstein Princeton University
Xavier Darzacq
Xavier Darzacq University of California, Berkeley
Maitreya J. Dunham
Maitreya J. Dunham University of Washington
Yixian Zheng
Yixian Zheng Carnegie Institution for Science
Michael Koval
Michael Koval Emory University
Joseph L. DeRisi
Joseph L. DeRisi University of California, San Francisco
Eric C. Greene
Eric C. Greene Columbia University
Philip Hieter
Philip Hieter University of British Columbia
Jennifer L. Gerton
Jennifer L. Gerton Stowers Institute for Medical Research

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