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Tatsuya Hirano

Tatsuya Hirano

D-Index & Metrics

Molecular Biology

D-Index
67
Citations
20329
World Ranking
1558
National Ranking
128

Research.com Recognitions

  • 2005 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Tatsuya Hirano is a researcher affiliated with RIKEN in Japan, specializing primarily in biochemistry, genetics, and molecular biology. Their academic output encompasses several closely related subfields such as molecular biology, cell biology, surgery, plant science, and pulmonary and respiratory medicine.

Their work covers research topics including genomics and chromatin dynamics, DNA and nucleic acid chemistry, RNA research and splicing, microtubule and mitosis dynamics, cancer therapeutics and mechanisms, gallbladder and bile duct disorders, and RNA interference and gene delivery.

Among recently published papers associated with Hirano are:

  • Cell cycle-specific phase separation regulated by protein charge blockiness, 2022, Nature Cell Biology
  • Variants That Affect Function of Calcium Channel TRPV6 Are Associated With Early-Onset Chronic Pancreatitis, 2020, Gastroenterology
  • Guiding functions of the C-terminal domain of topoisomerase IIα advance mitotic chromosome assembly, 2021, Nature Communications
  • Effect of gallbladder polyp size on the prediction and detection of gallbladder cancer, 2020, Surgical Endoscopy
  • Usefulness of several factors and clinical scoring models in preoperative diagnosis of complicated appendicitis, 2021, PLoS ONE

Frequent coauthors collaborating with Hirano include:

  • Keishi Shintomi
  • Kazuhisa Kinoshita
  • Shoji Tane
  • Yuuki Aizawa
  • Yuki Masahara-Negishi

Publication venues where Hirano's work frequently appears are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • PLoS ONE
  • eLife
  • Biophysical Journal

The scope of Hirano's research spans both fundamental and applied biomedical sciences, with frequent focus on molecular mechanisms related to cell cycle regulation, chromatin behavior, RNA processes, and disease mechanisms involving cancer and gallbladder disorders.

Recognition for their scientific contributions includes election as a Fellow of the American Association for the Advancement of Science (AAAS) in 2005.

Best Publications

  • Identification of Xenopus SMC protein complexes required for sister chromatid cohesion

    Ana Losada;Michiko Hirano;Tatsuya Hirano

  • Condensins, Chromosome Condensation Protein Complexes Containing XCAP-C, XCAP-E and a Xenopus Homolog of the Drosophila Barren Protein

    Tatsuya Hirano;Ryuji Kobayashi;Michiko Hirano

  • A heterodimeric coiled-coil protein required for mitotic chromosome condensation in vitro.

    Tatsuya Hirano;Timothy J. Mitchison

  • At the heart of the chromosome: SMC proteins in action

    Tatsuya Hirano

  • Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells.

    Takao Ono;Ana Losada;Michiko Hirano;Michael P. Myers

  • Human wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase

    Rita Gandhi;Peter J. Gillespie;Tatsuya Hirano

  • ATP-Dependent Positive Supercoiling of DNA by 13S Condensin: A Biochemical Implication for Chromosome Condensation

    Keiji Kimura;Tatsuya Hirano

  • Phosphorylation and Activation of 13S Condensin by Cdc2 in Vitro

    Keiji Kimura;Michiko Hirano;Ryuji Kobayashi;Tatsuya Hirano

  • Dynamic molecular linkers of the genome: the first decade of SMC proteins

    Ana Losada;Tatsuya Hirano

  • Condensin and cohesin display different arm conformations with characteristic hinge angles.

    David E. Anderson;Ana Paula Losada;Harold P. Erickson;Tatsuya Hirano

  • Condensin-Based Chromosome Organization from Bacteria to Vertebrates.

    Tatsuya Hirano

  • Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis.

    Ana Losada;Michiko Hirano;Tatsuya Hirano

  • 13S Condensin Actively Reconfigures DNA by Introducing Global Positive Writhe: Implications for Chromosome Condensation

    Keiji Kimura;Valentin V Rybenkov;Nancy J Crisona;Tatsuya Hirano

  • Condensins: universal organizers of chromosomes with diverse functions

    Tatsuya Hirano

  • Identification and characterization of SA/Scc3p subunits in the Xenopus and human cohesin complexes.

    Ana Losada;Tomoki Yokochi;Ryuji Kobayashi;Tatsuya Hirano

  • Spatial and Temporal Regulation of Condensins I and II in Mitotic Chromosome Assembly in Human Cells

    Takao Ono;Yuda Fang;David L. Spector;Tatsuya Hirano

  • The ABCs of SMC proteins: two-armed ATPases for chromosome condensation, cohesion, and repair.

    Tatsuya Hirano

  • Snap helix with knob and hole: Essential repeats in S. pombe nuclear protein nuc2 +

    Tatsuya Hirano;Noriyuki Kinoshita;Kosuke Morikawa;Mitsuhiro Yanagida

  • HEAT Repeats Associated with Condensins, Cohesins, and Other Complexes Involved in Chromosome-Related Functions

    Andrew F. Neuwald;Tatsuya Hirano

  • Isolation and characterization of Schizosaccharomyces pombe cutmutants that block nuclear division but not cytokinesis.

    Tatsuya Hirano;Shin-ichi Funahashi;Tadashi Uemura;Mitsuhiro Yanagida

Frequent Co-Authors

Ryuji Kobayashi
Ryuji Kobayashi The University of Texas MD Anderson Cancer Center
Detlev Schindler
Detlev Schindler University of Würzburg
Mitsuyoshi Nakao
Mitsuyoshi Nakao Kumamoto University
Masato T. Kanemaki
Masato T. Kanemaki National Institute of Genetics
Stefan Dimitrov
Stefan Dimitrov Grenoble Alpes University
Jason R. Swedlow
Jason R. Swedlow University of Dundee
Harold P. Erickson
Harold P. Erickson Duke University
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Yutaka Suzuki
Yutaka Suzuki University of Tokyo

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