2022 - Research.com Genetics and Molecular Biology in Austria Leader Award
Karl Mechtler mostly deals with Cell biology, Genetics, Biochemistry, Cohesin and Molecular biology. His Mitosis study in the realm of Cell biology connects with subjects such as Neuroblast. His work on Biochemistry deals in particular with Histone code, Histone methyltransferase, Histone lysine methylation, Peptide and Peptide sequence.
Karl Mechtler interconnects EZH2 and Histone H1 in the investigation of issues within Histone code. His work deals with themes such as Histone H2A, Chromatin remodeling and Histone H3, which intersect with Histone H1. His studies in Molecular biology integrate themes in fields like DNA and Cell culture, Transfection.
Karl Mechtler mainly focuses on Cell biology, Mass spectrometry, Biochemistry, Proteomics and Chromatography. Karl Mechtler has researched Cell biology in several fields, including Chromatin, Cohesin and Chromosome segregation. His Mass spectrometry research is multidisciplinary, incorporating perspectives in Combinatorial chemistry and Search engine.
His study in Biochemistry focuses on Histone methyltransferase and Histone code. His research integrates issues of Proteome and Computational biology in his study of Proteomics. His work investigates the relationship between Chromatography and topics such as Peptide that intersect with problems in Peptide sequence.
Karl Mechtler focuses on Cell biology, Mass spectrometry, Proteomics, Chromatin and CTCF. His Cell biology research is multidisciplinary, incorporating elements of Gene expression, Transcription factor, Mutant, Gene and Regulation of gene expression. The study incorporates disciplines such as False discovery rate, Search engine and Identification in addition to Mass spectrometry.
His Proteomics research is within the category of Biochemistry. In his research, Karl Mechtler performs multidisciplinary study on Biochemistry and Exonuclease. His work in Chromatin addresses issues such as Histone, which are connected to fields such as Centromere, NASP and Chaperone.
Cell biology, Mass spectrometry, Chromatin, Transcription factor and Computational biology are his primary areas of study. The concepts of his Cell biology study are interwoven with issues in Autophagy, ATG8, Quantitative proteomics, Ribosome and Kinetochore. His work in the fields of Mass spectrometry, such as Fragmentation, intersects with other areas such as Reagent, White paper and Reliability.
In general Chromatin study, his work on Cohesin often relates to the realm of CTCF, thereby connecting several areas of interest. His Transcription factor study integrates concerns from other disciplines, such as Kinase, Protein kinase A, Phosphorylation, Immune system and Induced pluripotent stem cell. His study with Phosphatase involves better knowledge in Biochemistry.
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Regulation of chromatin structure by site-specific histone H3 methyltransferases
S Rea;F Eisenhaber;D O'Carroll;B D Strahl.
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Monika Lachner;Dónal O'Carroll;Stephen Rea;Karl Mechtler.
Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.
Antoine H.F.M. Peters;Dónal O'Carroll;Harry Scherthan;Karl Mechtler.
Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin
Antoine H.F.M. Peters;Stefan Kubicek;Karl Mechtler;Roderick J. O'Sullivan.
Molecular Cell (2003)
The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.
Christian Plank;Berndt Oberhauser;Karl Mechtler;Christian Koch.
Journal of Biological Chemistry (1994)
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Stefan Kubicek;Roderick J. O'Sullivan;E. Michael August;Eugene R. Hickey.
Molecular Cell (2007)
The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells.
M Ogris;P Steinlein;M Kursa;K Mechtler.
Gene Therapy (1998)
Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery
Christian Plank;Karl Mechtler;Francis C. Szoka;Ernst Wagner.
Human Gene Therapy (1996)
Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.
Ernst Wagner;Kurt Zatloukal;Matt Cotten;Helen Kirlappos.
Proceedings of the National Academy of Sciences of the United States of America (1992)
Universal and confident phosphorylation site localization using phosphoRS.
Thomas Taus;Thomas Köcher;Peter Pichler;Carmen Paschke.
Journal of Proteome Research (2011)
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