World's Best Scientists 2026 revealed!
Award Badge
Genetics and Molecular Biology
Austria
2024

D-Index & Metrics

Molecular Biology

D-Index
95
Citations
42662
World Ranking
626
National Ranking
7

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Austria Leader Award
  • 2023 - Research.com Genetics and Molecular Biology in Austria Leader Award
  • 2022 - Research.com Genetics and Molecular Biology in Austria Leader Award

Overview

Karl Mechtler is affiliated with the Research Institute of Molecular Pathology in Austria. Their research expertise primarily spans the fields of Biochemistry, Genetics and Molecular Biology, and Chemistry, with significant contributions in subfields such as Molecular Biology, Spectroscopy, Cell Biology, Plant Science, and Nephrology.

Their work covers several main topics including:

  • Advanced Proteomics Techniques and Applications
  • Mass Spectrometry Techniques and Applications
  • Metabolomics and Mass Spectrometry Studies
  • RNA Research and Splicing
  • Genomics and Chromatin Dynamics
  • RNA modifications and cancer
  • Ubiquitin and proteasome pathways

Karl Mechtler has collaborated frequently with several researchers, including Manuel Matzinger, Karel Stejskal, Gerhard Dürnberger, Fränze Müller, and Viktoria Dorfer.

Their publications have appeared in a variety of journals, with frequent contributions to:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Journal of Proteome Research
  • eLife
  • Analytical Chemistry

Recent papers authored or co-authored by Karl Mechtler include:

  • A cross-kingdom conserved ER-phagy receptor maintains endoplasmic reticulum homeostasis during stress, 2020, eLife
  • ESCO1 and CTCF enable formation of long chromatin loops by protecting cohesinSTAG1 from WAPL, 2020, eLife
  • AKIRIN2 controls the nuclear import of proteasomes in vertebrates, 2021, Nature
  • Robust and Easy-to-Use One-Pot Workflow for Label-Free Single-Cell Proteomics, 2023, Analytical Chemistry
  • The biophysical, molecular, and anatomical landscape of pigeon CRY4: A candidate light-based quantal magnetosensor, 2020, Science Advances

Best Publications

  • Regulation of chromatin structure by site-specific histone H3 methyltransferases

    S Rea;F Eisenhaber;D O'Carroll;B D Strahl

  • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

    Monika Lachner;Dónal O'Carroll;Stephen Rea;Karl Mechtler

  • Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

    Antoine H.F.M. Peters;Dónal O'Carroll;Harry Scherthan;Karl Mechtler

  • Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin

    Antoine H.F.M. Peters;Stefan Kubicek;Karl Mechtler;Roderick J. O'Sullivan

  • The influence of endosome-disruptive peptides on gene transfer using synthetic virus-like gene transfer systems.

    Christian Plank;Berndt Oberhauser;Karl Mechtler;Christian Koch

  • Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

    Stefan Kubicek;Roderick J. O'Sullivan;E. Michael August;Eugene R. Hickey

  • Universal and confident phosphorylation site localization using phosphoRS.

    Thomas Taus;Thomas Köcher;Peter Pichler;Carmen Paschke

  • Activation of the Complement System by Synthetic DNA Complexes: A Potential Barrier for Intravenous Gene Delivery

    Christian Plank;Karl Mechtler;Francis C. Szoka;Ernst Wagner

  • The size of DNA/transferrin-PEI complexes is an important factor for gene expression in cultured cells.

    M Ogris;P Steinlein;M Kursa;K Mechtler

  • Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

    Ernst Wagner;Kurt Zatloukal;Matt Cotten;Helen Kirlappos

  • The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl

    Jörg Betschinger;Karl Mechtler;Juergen A. Knoblich

  • Wapl Controls the Dynamic Association of Cohesin with Chromatin

    Stephanie Kueng;Björn Hegemann;Beate H. Peters;Jesse J. Lipp

  • BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals.

    Ina Poser;Mihail Sarov;Mihail Sarov;James R.A. Hutchins;Jean Karim Hériché

  • Asymmetric Segregation of the Tumor Suppressor Brat Regulates Self-Renewal in Drosophila Neural Stem Cells

    Joerg Betschinger;Karl Mechtler;Karl Mechtler;Juergen A. Knoblich

  • Dissociation of cohesin from chromosome arms and loss of arm cohesion during early mitosis depends on phosphorylation of SA2.

    Silke Hauf;Elisabeth Roitinger;Birgit Koch;Christina M Dittrich

  • Systematic analysis of human protein complexes identifies chromosome segregation proteins.

    James R. A. Hutchins;Yusuke Toyoda;Björn Hegemann;Ina Poser

  • Protein phosphatase 2A protects centromeric sister chromatid cohesion during meiosis I

    Christian G Riedel;Vittorio L Katis;Vittorio L Katis;Yuki Katou;Saori Mori

  • Mitotic regulation of the human anaphase-promoting complex by phosphorylation.

    Claudine Kraft;Franz Herzog;Christian Gieffers;Karl Mechtler

  • Transferrin-polycation-mediated introduction of DNA into human leukemic cells: stimulation by agents that affect the survival of transfected DNA or modulate transferrin receptor levels.

    Matt Cotten;Francoise Längle-Rouault;Helen Kirlappos;Ernst Wagner

  • Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

    Stefan Schoeftner;Aditya K Sengupta;Stefan Kubicek;Karl Mechtler

Frequent Co-Authors

Jan-Michael Peters
Jan-Michael Peters Research Institute of Molecular Pathology
Alexander Schleiffer
Alexander Schleiffer Research Institute of Molecular Pathology
Tim Clausen
Tim Clausen Research Institute of Molecular Pathology
Gustav Ammerer
Gustav Ammerer University of Vienna
Kim Nasmyth
Kim Nasmyth University of Oxford
Josef M. Penninger
Josef M. Penninger University of British Columbia
Ernst Wagner
Ernst Wagner Ludwig-Maximilians-Universität München
Johannes Stadlmann
Johannes Stadlmann BOKU University
Anthony A. Hyman
Anthony A. Hyman Max Planck Institute of Molecular Cell Biology and Genetics
Thomas Jenuwein
Thomas Jenuwein Max Planck Society

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Exploring Molecular Biology opens doors to a wide range of interdisciplinary career opportunities. Many students interested in this field may also consider related online degrees that can complement or broaden job options in science, education, and healthcare.

For those looking to expand their scientific and analytical skillsets, pursuing an online history master's degree can develop research and interpretation skills valuable in science communication. Another popular route is library and information science—earning a degree from one of the cheapest masters in library science programs can lead to roles in data management or academic research support.

If you are interested in healthcare, several asha approved slp programs online let you fast-track a career in speech-language pathology—a high-demand area closely related to biology and neuroscience. Additionally, individuals from non-science backgrounds can leverage online bridge programs non-SLP majors to transition into communication sciences.

Online degree pathways offer flexible options to specialize or pivot within the ever-evolving landscape of biology and its allied fields.

Best Scientists Citing Karl Mechtler

Trending Scientists

Recently Published Articles