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Thomas Jenuwein

Thomas Jenuwein

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Genetics
Germany
2024
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Genetics and Molecular Biology
Germany
2024

D-Index & Metrics

Genetics

D-Index
98
Citations
76503
World Ranking
791
National Ranking
65

Molecular Biology

D-Index
98
Citations
76503
World Ranking
561
National Ranking
50

Research.com Recognitions

  • 2024 - Research.com Genetics in Germany Leader Award
  • 2024 - Research.com Genetics and Molecular Biology in Germany Leader Award
  • 2023 - Research.com Genetics in Germany Leader Award
  • 2019 - Fellow of the American Academy of Arts and Sciences
  • 2013 - Member of Academia Europaea
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Thomas Jenuwein is affiliated with the Max Planck Society in Germany and specializes in Biochemistry, Genetics, and Molecular Biology. Their research focuses predominantly on Molecular Biology with notable contributions to Immunology, Cancer Research, Plant Science, and Genetics.

Their main topics of study cover:

  • Genomics and Chromatin Dynamics
  • Epigenetics and DNA Methylation
  • RNA modifications and cancer
  • Chromosomal and Genetic Variations
  • Cancer-related gene regulation
  • Genetics and Neurodevelopmental Disorders
  • Acute Myeloid Leukemia Research

Thomas Jenuwein has published in several research venues, with frequent publications in:

  • Nature Communications
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Research Square (Research Square)
  • Nature Cell Biology
  • Proceedings of the National Academy of Sciences

Recent papers by Thomas Jenuwein include:

  • Heterochromatin establishment during early mammalian development is regulated by pericentromeric RNA and characterized by non-repressive H3K9me3 (2020, Nature Cell Biology)
  • Complete loss of H3K9 methylation dissolves mouse heterochromatin organization (2021, Nature Communications)
  • H1 linker histones silence repetitive elements by promoting both histone H3K9 methylation and chromatin compaction (2020, Proceedings of the National Academy of Sciences)
  • An LKB1-mitochondria axis controls TH17 effector function (2022, Nature)
  • Repetitive Elements Trigger RIG-I-like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells (2020, Immunity)

Frequent co-authors of Thomas Jenuwein are:

  • Galina Erikson
  • Megumi Onishi-Seebacher
  • Thomas Montavon
  • Nicholas Shukeir
  • Zoe Sawitzki

Thomas Jenuwein has been recognized by several awards and memberships, including:

  • Fellow of the American Academy of Arts and Sciences (2019)
  • Member of Academia Europaea (2013)
  • Member of the European Molecular Biology Organization (EMBO)

Best Publications

  • Translating the Histone Code

    Thomas Jenuwein;C. David Allis

  • Regulation of chromatin structure by site-specific histone H3 methyltransferases

    S Rea;F Eisenhaber;D O'Carroll;B D Strahl

  • Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.

    Monika Lachner;Dónal O'Carroll;Stephen Rea;Karl Mechtler

  • The molecular hallmarks of epigenetic control

    C. David Allis;Thomas Jenuwein

  • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

    Mario F Fraga;Esteban Ballestar;Ana Villar-Garea;Manuel Boix-Chornet

  • Loss of the Suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability.

    Antoine H.F.M. Peters;Dónal O'Carroll;Harry Scherthan;Karl Mechtler

  • Dicer-deficient mouse embryonic stem cells are defective in differentiation and centromeric silencing

    Chryssa Kanellopoulou;Stefan A. Muljo;Andrew L. Kung;Shridar Ganesan

  • Oncogene-induced senescence as an initial barrier in lymphoma development

    Melanie Braig;Soyoung Lee;Christoph Loddenkemper;Cornelia Rudolph

  • Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

    Bernhard Lehnertz;Yoshihide Ueda;Alwin A.H.A. Derijck;Ulrich Braunschweig

  • Partitioning and Plasticity of Repressive Histone Methylation States in Mammalian Chromatin

    Antoine H.F.M. Peters;Stefan Kubicek;Karl Mechtler;Roderick J. O'Sullivan

  • A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin

    Gunnar Schotta;Monika Lachner;Kavitha Sarma;Anja Ebert

  • A stem cell–like chromatin pattern may predispose tumor suppressor genes to DNA hypermethylation and heritable silencing

    Joyce E Ohm;Kelly M McGarvey;Xiaobing Yu;Linzhao Cheng

  • The many faces of histone lysine methylation.

    Monika Lachner;Thomas Jenuwein

  • Rb targets histone H3 methylation and HP1 to promoters

    Soren J. Nielsen;Robert Schneider;Uta-Maria Bauer;Andrew J. Bannister

  • The polycomb-group gene Ezh2 is required for early mouse development.

    O'Carroll D;Erhardt S;Pagani M;Barton Sc

  • Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression

    Gerda Lagger;Dónal O'Carroll;Martina Rembold;Harald Khier

  • p53 is regulated by the lysine demethylase LSD1

    Jing Huang;Roopsha Sengupta;Alexsandra B. Espejo;Min Gyu Lee

  • Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.

    Stefan Kubicek;Roderick J. O'Sullivan;E. Michael August;Eugene R. Hickey

  • An epigenetic road map for histone lysine methylation.

    Monika Lachner;Roderick J. O'Sullivan;Thomas Jenuwein

  • Mutant nuclear lamin A leads to progressive alterations of epigenetic control in premature aging

    Dale K. Shumaker;Thomas Dechat;Alexander Kohlmaier;Alexander Kohlmaier;Stephen A. Adam

Frequent Co-Authors

Antoine H.F.M. Peters
Antoine H.F.M. Peters Friedrich Miescher Institute
Gunnar Schotta
Gunnar Schotta Ludwig-Maximilians-Universität München
Gunter Reuter
Gunter Reuter Martin Luther University Halle-Wittenberg
Dónal O'Carroll
Dónal O'Carroll University of Edinburgh
Bernd Dörken
Bernd Dörken Charité - University Medicine Berlin
Karl Mechtler
Karl Mechtler Research Institute of Molecular Pathology
Danny Reinberg
Danny Reinberg University of Miami
Shelley L. Berger
Shelley L. Berger University of Pennsylvania
Christoph Loddenkemper
Christoph Loddenkemper Charité - University Medicine Berlin
Manel Esteller
Manel Esteller Josep Carreras Leukaemia Research Institute

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