What is he best known for?
The fields of study he is best known for:
His scientific interests lie mostly in Molecular biology, Histone code, Histone methyltransferase, Histone and Cell biology.
His research integrates issues of Histone H3, Transcription, Transcription factor, Histone deacetylase 5 and Histone deacetylase 2 in his study of Molecular biology.
His Histone code research incorporates elements of HDAC4 and Histone H1.
The various areas that Axel Imhof examines in his Histone methyltransferase study include Histone H2A, EZH2 and Histone methylation.
His study in Histone is interdisciplinary in nature, drawing from both Chromatin and Methylation.
His Cell biology study integrates concerns from other disciplines, such as Protein subunit, Biochemistry, Nucleosome, RNA polymerase II holoenzyme and Transcription preinitiation complex.
His most cited work include:
- Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer (1438 citations)
- Drosophila enhancer of Zeste/ESC complexes have a histone H3 methyltransferase activity that marks chromosomal Polycomb sites. (1254 citations)
- Acetylation of general transcription factors by histone acetyltransferases (557 citations)
What are the main themes of his work throughout his whole career to date?
The scientist’s investigation covers issues in Cell biology, Chromatin, Histone, Genetics and Biochemistry.
The Cell biology study combines topics in areas such as Gene expression, Transcription, Nucleosome, Histone code and Molecular biology.
His research in Histone code intersects with topics in Histone H2A, Histone methyltransferase, Histone-modifying enzymes, Histone H1 and Epigenomics.
He has researched Histone methyltransferase in several fields, including Histone H3, EZH2 and Histone methylation.
His Chromatin research includes elements of DNA repair and DNA methylation.
His work deals with themes such as Acetylation, Epigenetics, Methylation and Computational biology, which intersect with Histone.
He most often published in these fields:
- Cell biology (51.90%)
- Chromatin (35.86%)
- Histone (30.80%)
What were the highlights of his more recent work (between 2017-2021)?
- Cell biology (51.90%)
- Chromatin (35.86%)
- Epigenetics (14.77%)
In recent papers he was focusing on the following fields of study:
Axel Imhof spends much of his time researching Cell biology, Chromatin, Epigenetics, Histone and Computational biology.
Axel Imhof combines subjects such as Transcription, Nucleosome, Heterochromatin, Regulation of gene expression and Cell type with his study of Cell biology.
His Chromatin research integrates issues from Gene expression and Chaperone.
His work in Epigenetics addresses subjects such as Cell cycle, which are connected to disciplines such as Cell division.
Histone and Acetylation are commonly linked in his work.
His Computational biology research is multidisciplinary, incorporating perspectives in Proteomics and Multi omics.
Between 2017 and 2021, his most popular works were:
- Toll-like Receptor Signaling Rewires Macrophage Metabolism and Promotes Histone Acetylation via ATP-Citrate Lyase. (41 citations)
- SETDB1-dependent heterochromatin stimulates alternative lengthening of telomeres (33 citations)
- Tyrosine-1 of RNA Polymerase II CTD Controls Global Termination of Gene Transcription in Mammals. (33 citations)
In his most recent research, the most cited papers focused on:
Cell biology, Chromatin, Histone, Epigenetics and Nucleosome are his primary areas of study.
His biological study spans a wide range of topics, including Biogenesis, Mitochondrial ribosome, Telomere, Heterochromatin and Condensin.
His Chromatin research is mostly focused on the topic Histone H3.
While the research belongs to areas of Histone, Axel Imhof spends his time largely on the problem of Acetylation, intersecting his research to questions surrounding Linker DNA, HDAC1, RBBP4 and Toll-like receptor.
His studies in Epigenetics integrate themes in fields like Histone methylation, DNA methylation, Computational biology, Transcription and Methionine.
In his work, Reprogramming is strongly intertwined with Metabolism, which is a subfield of Histone methyltransferase.
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