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Molecular Biology

D-Index
52
Citations
9587
World Ranking
2440
National Ranking
162

Overview

Gernot Längst is affiliated with the University of Regensburg in Germany and specializes in biochemistry, genetics, and molecular biology. Their research output primarily focuses on molecular biology, with significant contributions also in plant science and infectious diseases.

The scientist has published extensively on topics related to genomics and chromatin dynamics, RNA and protein synthesis mechanisms, RNA research and splicing, plant molecular biology research, cancer-related molecular mechanisms, epigenetics, DNA methylation, and plant reproductive biology.

Recent notable publications include:

  • "Mechanisms governing the pioneering and redistribution capabilities of the non-classical pioneer PU.1" (2020, Nature Communications)
  • "Super-resolution in situ analysis of active ribosomal DNA chromatin organization in the nucleolus" (2020, Scientific Reports)
  • "ARMADILLO REPEAT ONLY proteins confine Rho GTPase signalling to polar growth sites" (2020, Nature Plants)
  • "The RALF signaling pathway regulates cell wall integrity during pollen tube growth in maize" (2023, The Plant Cell)
  • "RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structure" (2020, Journal of Biological Chemistry)

Gernot Längst frequently collaborates with several co-authors, including:

  • Uwe Schwartz
  • Simon Holzinger
  • Thomas Dresselhaus
  • Harald Wodrich
  • Sara Wernig-Zorc

Their work is often published in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Nature Plants
  • International Journal of Molecular Sciences
  • Nucleic Acids Research

The range of research topics and publications reflect a focus on molecular mechanisms at the chromatin and RNA levels, as well as specialized studies in plant biology. Their contributions span experimental and analytical approaches to understanding chromatin organization, transcriptional regulation, and signaling pathways in various biological contexts.

Best Publications

  • Nucleosome Movement by CHRAC and ISWI without Disruption or trans-Displacement of the Histone Octamer

    Gernot Längst;Edgar J Bonte;Davide F.V Corona;Peter B Becker

  • Initial genomics of the human nucleolus.

    Attila Németh;Ana Conesa;Javier Santoyo-Lopez;Ignacio Medina

  • NoRC--a novel member of mammalian ISWI-containing chromatin remodeling machines.

    Ralf Strohner;Attila Nemeth;Petr Jansa;Urs Hofmann-Rohrer

  • ISWI Is an ATP-Dependent Nucleosome Remodeling Factor

    Davide F.V Corona;Gernot Längst;Cedric R Clapier;Edgar J Bonte

  • The DNA chaperone HMGB1 facilitates ACF/CHRAC‐dependent nucleosome sliding

    Tiziana Bonaldi;Gernot Längst;Ralf Strohner;Peter B. Becker

  • Critical role for the histone H4 N terminus in nucleosome remodeling by ISWI.

    Cedric R. Clapier;Gernot Längst;Davide F. V. Corona;Peter B. Becker

  • Nucleosome mobilization and positioning by ISWI-containing chromatin-remodeling factors.

    Gernot Längst;Peter B. Becker

  • dMi-2 and ISWI chromatin remodelling factors have distinct nucleosome binding and mobilization properties.

    Alexander Brehm;Gernot Längst;Johannes Kehle;Cedric R. Clapier

  • DNMT1 but not its interaction with the replication machinery is required for maintenance of DNA methylation in human cells.

    Fabio Spada;Andrea Haemmer;David Kuch;Ulrich Rothbauer

  • Genome organization in and around the nucleolus

    Attila Németh;Gernot Längst

  • Nucleosome remodeling: one mechanism, many phenomena?

    Gernot Längst;Peter B. Becker

  • The dMi-2 chromodomains are DNA binding modules important for ATP-dependent nucleosome mobilization.

    Karim Bouazoune;Angelika Mitterweger;Gernot Längst;Axel Imhof

  • The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

    Max Felle;Saskia Joppien;Attila Németh;Sarah Diermeier

  • Acf1, the largest subunit of CHRAC, regulates ISWI-induced nucleosome remodelling.

    Anton Eberharter;Simona Ferrari;Gernot Längst;Tobias Straub

  • Chromatin Remodelers: From Function to Dysfunction.

    Gernot Längst;Laura Manelyte

  • ISWI Induces Nucleosome Sliding on Nicked DNA

    Gernot Längst;Peter B. Becker

  • Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

    Jesús Espada;Esteban Ballestar;Raffaella Santoro;Mario F. Fraga

  • Epigenetic control of RNA polymerase I transcription in mammalian cells.

    Ingrid Grummt;Gernot Längst

  • High Mobility Group 1 Protein Is Not Stably Associated with the Chromosomes of Somatic Cells

    Luca Falciola;Fabio Spada;Sabina Calogero;Gernot Längst

  • DNA sequence- and conformation-directed positioning of nucleosomes by chromatin-remodeling complexes

    Karsten Rippe;Anna Schrader;Philipp Riede;Ralf Strohner

Frequent Co-Authors

Peter B. Becker
Peter B. Becker Ludwig-Maximilians-Universität München
Ingrid Grummt
Ingrid Grummt German Cancer Research Center
Karsten Rippe
Karsten Rippe German Cancer Research Center
Axel Imhof
Axel Imhof Ludwig-Maximilians-Universität München
Michael Rehli
Michael Rehli University of Regensburg
Heinrich Leonhardt
Heinrich Leonhardt Ludwig-Maximilians-Universität München
Elisabeth Kremmer
Elisabeth Kremmer Max Planck Society
Peter R. Cook
Peter R. Cook University of Oxford
Lothar Schermelleh
Lothar Schermelleh University of Oxford
Brendan S. Crabb
Brendan S. Crabb Monash University

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