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Bradley R. Cairns

Bradley R. Cairns

D-Index & Metrics

Genetics

D-Index
85
Citations
31096
World Ranking
1298
National Ranking
616

Research.com Recognitions

  • 2017 - Fellow of the American Academy of Arts and Sciences

Overview

Bradley R. Cairns is a researcher affiliated with the University of Utah in the United States. Their work spans a broad scope within biochemistry, genetics, and molecular biology, with a significant emphasis on molecular biology and related subfields. Their publication record includes 74 papers in Biochemistry, Genetics and Molecular Biology and 23 publications in Medicine.

Their research incorporates various subfields such as molecular biology, genetics, immunology, public health, environmental and occupational health, and reproductive medicine. The main scientific topics Bradley R. Cairns addresses include genomics and chromatin dynamics, epigenetics and DNA methylation, genetic and clinical aspects of sex determination and chromosomal abnormalities, pluripotent stem cell research, chromatin remodeling and cancer, sperm and testicular function, and reproductive biology and fertility.

Frequent publication venues for Cairns' work reflect their interdisciplinary focus and include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Developmental Cell
  • Cell Stem Cell
  • Nature Cell Biology
  • Genome Research

Selected recent papers illustrate the range and focus of their research:

  • "The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty", 2020, Cell Stem Cell
  • "PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications", 2021, Nature Cell Biology
  • "Single-cell analysis of the developing human testis reveals somatic niche cell specification and fetal germline stem cell establishment", 2021, Cell Stem Cell
  • "Single-cell analysis of human testis aging and correlation with elevated body mass index", 2022, Developmental Cell
  • "Dissecting mammalian spermatogenesis using spatial transcriptomics", 2021, Cell Reports

Bradley R. Cairns has collaborated repeatedly with several researchers, indicating sustained research partnerships. Frequent co-authors include:

  • Jingtao Guo
  • Xichen Nie
  • Yixuan Guo
  • James M. Hotaling
  • Edward J. Grow

In recognition of contributions to their fields, Cairns was elected a Fellow of the American Academy of Arts and Sciences in 2017.

Best Publications

  • The Biology of Chromatin Remodeling Complexes

    Cedric R. Clapier;Bradley R. Cairns

  • Distinctive chromatin in human sperm packages genes for embryo development

    Saher Sue Hammoud;David A. Nix;Haiying Zhang;Jahnvi Purwar

  • ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression

    Xiaobing Shi;Tao Hong;Kay L. Walter;Mark Ewalt

  • Mechanisms of action and regulation of ATP-dependent chromatin-remodelling complexes

    Cedric R. Clapier;Janet Iwasa;Bradley R. Cairns;Craig L. Peterson

  • Diversity and specialization of mammalian SWI/SNF complexes.

    Weidong Wang;Yutong Xue;Sharleen Zhou;Ann Kuo

  • RSC, an Essential, Abundant Chromatin-Remodeling Complex

    Bradley R. Cairns;Yahli Lorch;Yang Li;Mincheng Zhang

  • DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45

    Kunal Rai;Ian J. Huggins;Smitha R. James;Adam R. Karpf

  • Chromatin remodelling: the industrial revolution of DNA around histones

    Anjanabha Saha;Jacqueline Wittmeyer;Bradley R. Cairns

  • Genome-Wide Dynamics of Htz1, a Histone H2A Variant that Poises Repressed/Basal Promoters for Activation through Histone Loss

    Haiying Zhang;Haiying Zhang;Douglas N. Roberts;Douglas N. Roberts;Bradley R. Cairns;Bradley R. Cairns

  • Conserved roles of mouse DUX and human DUX4 in activating cleavage-stage genes and MERVL/HERVL retrotransposons

    Peter G. Hendrickson;Jessie A. Doráis;Edward J. Grow;Jennifer L. Whiddon

  • The logic of chromatin architecture and remodelling at promoters

    Bradley R. Cairns

  • A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast.

    Bradley R. Cairns;Young Joon Kim;Michael H. Sayre;Brehon C. Laurent

  • The adult human testis transcriptional cell atlas

    Jingtao Guo;Edward J. Grow;Hana Mlcochova;Geoffrey J. Maher

  • Nucleosome mobilization catalysed by the yeast SWI/SNF complex

    Iestyn Whitehouse;Andrew Flaus;Bradley R. Cairns;Malcolm F. White

  • Identification of direct targets and modified bases of RNA cytosine methyltransferases

    Vahid Khoddami;Bradley R Cairns

  • Reprogramming the maternal zebrafish genome after fertilization to match the paternal methylation pattern.

    Magdalena E. Potok;Magdalena E. Potok;David A. Nix;Timothy J. Parnell;Timothy J. Parnell;Bradley R. Cairns;Bradley R. Cairns

  • Distinct roles for the RSC and Swi/Snf ATP-dependent chromatin remodelers in DNA double-strand break repair

    Bob Chai;Jian Huang;Bradley R. Cairns;Brehon C. Laurent;Brehon C. Laurent

  • Activation Domain–Mediated Targeting of the SWI/SNF Complex to Promoters Stimulates Transcription from Nucleosome Arrays

    Kristen E Neely;Ahmed H Hassan;Annika E Wallberg;David J Steger

  • Chromatin and Transcription Transitions of Mammalian Adult Germline Stem Cells and Spermatogenesis

    Saher Sue Hammoud;Diana H.P. Low;Diana H.P. Low;Chongil Yi;Douglas T. Carrell

  • Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility

    Saher Sue Hammoud;Jahnvi Purwar;Christian Pflueger;Bradley R. Cairns;Bradley R. Cairns

Frequent Co-Authors

David A. Jones
David A. Jones Australian National University
Paul Tempst
Paul Tempst Memorial Sloan Kettering Cancer Center
Hediye Erdjument-Bromage
Hediye Erdjument-Bromage New York University
Roger D. Kornberg
Roger D. Kornberg Stanford University
Adam R. Karpf
Adam R. Karpf University of Nebraska Medical Center
John R. Hoidal
John R. Hoidal University of Utah
Juan M. Vaquerizas
Juan M. Vaquerizas Max Planck Society
Magdalena Zernicka-Goetz
Magdalena Zernicka-Goetz California Institute of Technology
Ernesto Guccione
Ernesto Guccione Icahn School of Medicine at Mount Sinai
Jesper Q. Svejstrup
Jesper Q. Svejstrup University of Copenhagen

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