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Biology and Biochemistry

D-Index
87
Citations
22431
World Ranking
2887
National Ranking
1480

Medicine

D-Index
87
Citations
22235
World Ranking
13805
National Ranking
7007

Research.com Recognitions

  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians
  • Member of the Association of American Physicians

Overview

John R. Hoidal is affiliated with the University of Utah in the United States and has contributed extensively to the fields of medicine and biochemistry, genetics, and molecular biology. Their research spans multiple subfields including pulmonary and respiratory medicine, molecular biology, clinical biochemistry, infectious diseases, and physiology.

Their work covers a range of topics with a strong focus on chronic obstructive pulmonary disease (COPD) research, advanced glycation end products, and the molecular mechanisms underlying oxidative stress. Additional areas of research include cystic fibrosis, microRNA in disease regulation, COVID-19 clinical research, and cardiovascular and exercise physiology.

  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Advanced Glycation End Products research
  • Genomics, phytochemicals, and oxidative stress
  • Cystic Fibrosis Research Advances
  • MicroRNA in disease regulation
  • COVID-19 Clinical Research Studies
  • Cardiovascular and exercise physiology

Their recent scholarly publications demonstrate a focus on oxidative stress and receptor pathways related to pulmonary and cardiac conditions. Key papers include:

  • "Reductive stress impairs myogenic differentiation" (2020) published in Redox Biology
  • "Soluble receptor for advanced glycation end products (sRAGE) as a biomarker of COPD" (2021) published in Respiratory Research
  • "Reductive Stress Causes Pathological Cardiac Remodeling and Diastolic Dysfunction" (2020) published in Antioxidants and Redox Signaling
  • "Identification of Nrf2-responsive microRNA networks as putative mediators of myocardial reductive stress" (2021) published in Scientific Reports
  • "Impairing RAGE signaling promotes survival and limits disease pathogenesis following SARS-CoV-2 infection in mice" (2022) published in JCI Insight

These publications emphasize pathways involving reductive stress, receptor for advanced glycation end products (RAGE), and myocardial remodeling, as well as implications for infectious disease processes such as COVID-19.

John R. Hoidal frequently collaborates with several researchers, including:

  • Tapan K. Mukherjee
  • Parth Malik
  • Karl Sanders
  • Robert Paine
  • Namakkal S. Rajasekaran

Their work has appeared in a variety of peer-reviewed venues that align with their research interests, including Redox Biology, Respiratory Research, Antioxidants and Redox Signaling, Scientific Reports, and JCI Insight.

John R. Hoidal holds membership in professional organizations such as the Association of American Physicians, indicating engagement with broader medical scientific communities.

Best Publications

  • Oxygen free radicals in ischemic acute renal failure in the rat.

    M S Paller;J R Hoidal;T F Ferris

  • Role of TNFα in pulmonary pathophysiology

    Srirupa Mukhopadhyay;John R Hoidal;Tapan K Mukherjee

  • Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters.

    R C Kao;N G Wehner;K M Skubitz;B H Gray

  • Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

    Anne Sturrock;Barbara Cahill;Kimberly Norman;Thomas P. Huecksteadt

  • Potential mechanism of emphysema: alpha 1-proteinase inhibitor recovered from lungs of cigarette smokers contains oxidized methionine and has decreased elastase inhibitory capacity.

    Harvey Carp;Frederick Miller;John R. Hoidal;Aaron Janoff

  • Characterization of proteinase-3 (PR-3), a neutrophil serine proteinase. Structural and functional properties.

    Narayanam V. Rao;Nancy G. Wehner;Bruce C. Marshall;William R. Gray

  • The development of emphysema in cigarette smoke-exposed mice is strain dependent.

    Alexei Guerassimov;Yuma Hoshino;Yasutaka Takubo;Antony Turcotte

  • Generation of Hydroxyl Radical by Enzymes, Chemicals, and Human Phagocytes In Vitro: DETECTION WITH THE ANTI-INFLAMMATORY AGENT, DIMETHYL SULFOXIDE

    John E. Repine;John W. Eaton;M. W. Anders;John R. Hoidal

  • Alveolar Hemorrhage Syndromes: Diffuse Microvascular Lung Hemorrhage in Immune and Idiopathic Disorders

    James W. Leatherman;Scott F. Davies;John R. Hoidal

  • Acute exercise stress activates Nrf2/ARE signaling and promotes antioxidant mechanisms in the myocardium

    Vasanthi R. Muthusamy;Sankaranarayanan Kannan;Kamal Sadhaasivam;Sellamuthu S. Gounder

  • A candidate gene approach identifies the CHRNA5-A3-B4 region as a risk factor for age-dependent nicotine addiction.

    Robert B Weiss;Timothy B. Baker;Dale Sherman Cannon;Andrew Von Niederhausern

  • Pulmonary inflammation due to oxygen toxicity: involvement of chemotactic factors and polymorphonuclear leukocytes.

    Richard B. Fox;John R. Hoidal;David M. Brown;John E. Repine

  • Expression of a metalloproteinase that degrades native type V collagen and denatured collagens by cultured human alveolar macrophages.

    Margaret S. Hibbs;John R. Hoidal;Andrew H. Kang

  • NOX5 NAD(P)H oxidase regulates growth and apoptosis in DU 145 prostate cancer cells.

    Sukhdev S. Brar;Zachary Corbin;Thomas P. Kennedy;Richelle Hemendinger

  • Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers

    John R. Hoidal;Richard B. Fox;Paul A. LeMarbe;Robert Perri

  • Role of reactive oxygen species in reperfusion injury of the rabbit lung.

    Thomas P. Kennedy;N. V. Rao;Christopher Hopkins;Larry Pennington

  • Effect of tumor necrosis factor-α and interleukin-1α on heme oxygenase-1 expression in human endothelial cells

    Christi M. Terry;Jennifer A. Clikeman;John R. Hoidal;Karleen S. Callahan

  • Copper-dependent Inflammation and Nuclear Factor- κ B Activation by Particulate Air Pollution

    Thomas P. Kennedy;Andrew J. Ghio;William Reed;James Samet

  • An NAD(P)H oxidase regulates growth and transcription in melanoma cells.

    Sukhdev S. Brar;Thomas P. Kennedy;Anne B. Sturrock;Thomas P. Huecksteadt

  • Lung T cells in hypersensitivity pneumonitis

    James W. Leatherman;Alfred F. Michael;Bruce A. Schwartz;John R. Hoidal

Frequent Co-Authors

John E. Repine
John E. Repine University of Colorado Denver
Phillip K. Peterson
Phillip K. Peterson University of Minnesota
E. Dale Abel
E. Dale Abel University of California, Los Angeles
Paul G. Quie
Paul G. Quie University of Minnesota
James G. White
James G. White University of Minnesota
Irvin E. Liener
Irvin E. Liener University of Minnesota
Victor M. Darley-Usmar
Victor M. Darley-Usmar University of Alabama at Birmingham
Bradley R. Cairns
Bradley R. Cairns University of Utah
Mark Leppert
Mark Leppert University of Utah
Aldrin V. Gomes
Aldrin V. Gomes University of California, Davis

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