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Biology and Biochemistry

D-Index
57
Citations
15683
World Ranking
13618
National Ranking
5777

Overview

Larissa A. Shimoda is affiliated with Johns Hopkins University in the United States. Their research focuses primarily on the fields of Medicine and Biochemistry, Genetics and Molecular Biology, with significant contributions to pulmonary and respiratory medicine, molecular biology, physiology, cardiology and cardiovascular medicine, and surgery.

The scientist's main research topics include pulmonary hypertension research and treatments, ion transport and channel regulation, neuroscience of respiration and sleep, cardiovascular function and risk factors, high altitude and hypoxia, mitochondrial function and pathology, and sleep and wakefulness research.

Their frequent coauthors include Karthik Suresh, Xin Yun, Mahendra Damarla, Nicolas Philip, and Haiyang Jiang. These collaborations have contributed to a substantial body of work seen in several respected publication venues.

Larissa A. Shimoda has published extensively in the following venues:

  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Physiology
  • The FASEB Journal
  • bioRxiv (Cold Spring Harbor Laboratory)
  • American Journal of Respiratory Cell and Molecular Biology

Recent publications by the scientist include:

  • Chronic Intermittent Hypoxia Enhances Pathological Tau Seeding, Propagation, and Accumulation and Exacerbates Alzheimer-like Memory and Synaptic Plasticity Deficits and Molecular Signatures, 2021, Biological Psychiatry
  • Cellular Pathways Promoting Pulmonary Vascular Remodeling by Hypoxia, 2020, Physiology
  • Contribution of fatty acid oxidation to the pathogenesis of pulmonary hypertension, 2022, American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Upregulation of Aquaporin 1 Mediates Increased Migration and Proliferation in Pulmonary Vascular Cells From the Rat SU5416/Hypoxia Model of Pulmonary Hypertension, 2021, Frontiers in Physiology
  • Transpulmonary amino acid metabolism in the sugen hypoxia model of pulmonary hypertension, 2023, Pulmonary Circulation

Best Publications

  • Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia

    Huafeng Zhang;Marta Bosch-Marce;Larissa A. Shimoda;Yee Sun Tan

  • Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

    Eric V. Dang;Joseph Barbi;Huang Yu Yang;Huang Yu Yang;Dilini Jinasena

  • HIF-1 Regulates Cytochrome Oxidase Subunits to Optimize Efficiency of Respiration in Hypoxic Cells

    Ryo Fukuda;Huafeng Zhang;Jung whan Kim;Larissa Shimoda

  • Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

    Aimee Y. Yu;Larissa A. Shimoda;Narayan V. Iyer;David L. Huso

  • Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

    Aimee Y. Yu;Maria G. Frid;Larissa A. Shimoda;Charles M. Wiener

  • Hypoxia Inducible Factor 1 Mediates Hypoxia-Induced TRPC Expression and Elevated Intracellular Ca2+ in Pulmonary Arterial Smooth Muscle Cells

    Jian Wang;Letitia Weigand;Wenju Lu;J.T. Sylvester

  • HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease.

    Larissa A. Shimoda;Gregg L. Semenza

  • Capacitative calcium entry and TRPC channel proteins are expressed in rat distal pulmonary arterial smooth muscle.

    Jian Wang;L. A. Shimoda;J. T. Sylvester

  • Vascular remodeling in pulmonary hypertension

    Larissa A. Shimoda;Steven S. Laurie

  • Partial HIF-1α deficiency impairs pulmonary arterial myocyte electrophysiological responses to hypoxia

    Larissa A. Shimoda;Dominador J. Manalo;James S. K. Sham;Gregg L. Semenza

  • HIF-1 regulates hypoxic induction of NHE1 expression and alkalinization of intracellular pH in pulmonary arterial myocytes.

    Larissa A. Shimoda;Michele Fallon;Sarah Pisarcik;Jian Wang

  • Carbon monoxide reverses established pulmonary hypertension

    Brian S. Zuckerbraun;Beek Yoke Chin;Barbara Wegiel;Timothy R. Billiar

  • Acute hypoxia increases intracellular [Ca2+] in pulmonary arterial smooth muscle by enhancing capacitative Ca2+ entry.

    Jian Wang;Larissa A. Shimoda;Letitia Weigand;Wenqian Wang

  • Role of the TGF-β/Alk5 Signaling Pathway in Monocrotaline-induced Pulmonary Hypertension

    Ari L. Zaiman;Megan Podowski;Satya Medicherla;Kimberley Gordy

  • Regulation of Gene Expression by HIF‐1

    Gregg L. Semenza;Larissa A. Shimoda;Nanduri R. Prabhakar

  • Differences in STIM1 and TRPC expression in proximal and distal pulmonary arterial smooth muscle are associated with differences in Ca2+ responses to hypoxia

    Wenju Lu;Jian Wang;Larissa A. Shimoda;J. T. Sylvester

  • L-type Ca2+ channels, resting [Ca2+](i), and ET-1-induced responses in chronically hypoxic pulmonary myocytes

    Larissa A. Shimoda;James S. K. Sham;Tenille H. Shimoda;J. T. Sylvester

  • Inhibition of hypoxic pulmonary vasoconstriction by antagonists of store-operated Ca2+ and nonselective cation channels.

    Letitia A Weigand;Joshua Foxson;Jian Wang;Larissa A Shimoda

  • Inhibition of voltage-gated K+ current in rat intrapulmonary arterial myocytes by endothelin-1

    Larissa A. Shimoda;J. T. Sylvester;James S. K. Sham

  • Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment

    Haiquan Lu;Ivan Chen;Larissa A. Shimoda;Youngrok Park

Frequent Co-Authors

Gregg L. Semenza
Gregg L. Semenza Johns Hopkins University School of Medicine
Naresh M. Punjabi
Naresh M. Punjabi University of Miami
Paul M. Hassoun
Paul M. Hassoun Johns Hopkins University
Rory E. Morty
Rory E. Morty Max Planck Society
Hunter C. Champion
Hunter C. Champion Mercer University
Bradley J. Undem
Bradley J. Undem Johns Hopkins University School of Medicine
Huafeng Zhang
Huafeng Zhang University of Science and Technology of China
Rubin M. Tuder
Rubin M. Tuder University of Colorado Denver
Alexander D. Verin
Alexander D. Verin Augusta University
Steve N. Georas
Steve N. Georas University of Rochester Medical Center

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