World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
47
Citations
14856
World Ranking
18558
National Ranking
7583

Overview

James B. Rottman is affiliated with Bluebird Bio in the United States. Their research spans multiple fields within biochemistry, genetics, molecular biology, and medicine, with significant focus on molecular biology and oncology. The scientist has contributed to 24 publications in biochemistry, genetics, and molecular biology, and 19 in medicine.

The subfields of study covered by their work include molecular biology, oncology, immunology, genetics, and infectious diseases. Key research topics are:

  • CAR-T cell therapy research
  • RNA Interference and Gene Delivery
  • Virus-based gene therapy research
  • CRISPR and Genetic Engineering
  • T-cell and B-cell Immunology
  • Immune Cell Function and Interaction
  • Wnt/β-catenin signaling in development and cancer

Recent publications illustrate a focus on gene therapy, immunology, and cancer research. Selected papers include:

  • Myelodysplastic syndrome unrelated to lentiviral vector in a patient treated with gene therapy for sickle cell disease, 2020, Blood Advances
  • mDKN-01, a Novel Anti-DKK1 mAb, Enhances Innate Immune Responses in the Tumor Microenvironment, 2020, Molecular Cancer Research
  • Safety, Efficacy, and Biomarker Results from a Phase Ib Study of the Anti-DKK1 Antibody DKN-01 in Combination with Pembrolizumab in Advanced Esophagogastric Cancers, 2021, Molecular Cancer Therapeutics
  • Design of an Interferon-Resistant Oncolytic HSV-1 Incorporating Redundant Safety Modalities for Improved Tolerability, 2020, Molecular Therapy - Oncolytics
  • B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primates, 2024, Blood

The scientist frequently publishes in the journal Blood, with seven publications, and has also contributed to Blood Advances, Molecular Cancer Research, Molecular Cancer Therapeutics, and Regular and Young Investigator Award Abstracts.

Frequent collaborators include Cecilia Cotta-Ramusino, Rahul Palchaudhuri, Leslie S. Kean, Ulrike Gerdemann, and Hari Pujar, each with multiple joint publications ranging from five to six coauthored works.

Best Publications

  • The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

    Shixin Qin;James B. Rottman;Paul Myers;Nasim Kassam

  • Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

    Torben L. Sørensen;Marie Tani;Jakob Jensen;Virginia Pierce

  • CCR5+ and CXCR3+ T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions

    Konstantin E. Balashov;James B. Rottman;Howard L. Weiner;Wayne W. Hancock

  • The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells

    J. J. Campbell;J. J. Campbell;G. Haraldsen;G. Haraldsen;G. Haraldsen;J. Pan;J. Rottman

  • CCR5 Levels and Expression Pattern Correlate with Infectability by Macrophage-tropic HIV-1, In Vitro

    Lijun Wu;William A. Paxton;Nasim Kassam;Nancy Ruffing

  • Enhanced expression of eotaxin and CCR3 mRNA and protein in atopic asthma. Association with airway hyperresponsiveness and predominant co-localization of eotaxin mRNA to bronchial epithelial and endothelial cells.

    Sun Ying;Douglas S. Robinson;Qiu Meng;James Rottman

  • Monoclonal antibodies specific for beta 7 integrin and mucosal addressin cell adhesion molecule-1 (MAdCAM-1) reduce inflammation in the colon of scid mice reconstituted with CD45RBhigh CD4+ T cells.

    D Picarella;P Hurlbut;J Rottman;X Shi

  • Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection.

    Engin Özkaynak;Wei Gao;Nida Shemmeri;Chichung Wang

  • The costimulatory molecule ICOS plays an important role in the immunopathogenesis of EAE

    James B. Rottman;Tammy Smith;James R. Tonra;Kenneth Ganley

  • Identification of Functional Roles for Both IL-17RB and IL-17RA in Mediating IL-25-Induced Activities

    Erika A. Rickel;Lori A. Siegel;Bo-Rin Park Yoon;James B. Rottman

  • Programmed Death-1 Targeting Can Promote Allograft Survival

    Engin Özkaynak;Liqing Wang;Liqing Wang;Andrew Goodearl;Kevin McDonald

  • Cellular localization of the chemokine receptor CCR5. Correlation to cellular targets of HIV-1 infection.

    James B. Rottman;Kenneth P. Ganley;Kenneth Williams;Lijun Wu

  • Innate lymphoid cells responding to IL-33 mediate airway hyperreactivity independently of adaptive immunity

    Hye Young Kim;Ya Jen Chang;Srividya Subramanian;Hyun Hee Lee

  • Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis

    Kenneth J. Katschke;James B. Rottman;Jeffrey H. Ruth;Shixin Qin

  • ICOS is critical for T helper cell–mediated lung mucosal inflammatory responses

    Jose Angel Gonzalo;Jane Tian;Tracy Delaney;Justin Corcoran

  • Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

    Joseph R. Maxwell;Yu Zhang;William A. Brown;Carole L. Smith

  • Potential Role of the Chemokine Receptors CXCR3, CCR4, and the Integrin αEβ7 in the Pathogenesis of Psoriasis Vulgaris

    James B Rottman;Tammy L Smith;Kenneth G Ganley;Toyoko Kikuchi

  • Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependent.

    James B. Rottman;Anthony J. Slavin;Anthony J. Slavin;Robert Silva;Howard L. Weiner;Howard L. Weiner

  • Selective lymphocyte chemokine receptor expression in the rheumatoid joint.

    Jeffrey H. Ruth;James B. Rottman;Kenneth J. Katschke;Shixin Qin

  • Involvement of CD14, toll-like receptors 2 and 4, and MyD88 in the host response to the fungal pathogen Cryptococcus neoformans in vivo.

    Lauren E. Yauch;Michael K. Mansour;Shmuel Shoham;James B. Rottman

Frequent Co-Authors

Wayne W. Hancock
Wayne W. Hancock University of Pennsylvania
Charles R. Mackay
Charles R. Mackay Qilu University of Technology
Anthony J. Coyle
Anthony J. Coyle Takeda (United States)
Jose-Carlos Gutierrez-Ramos
Jose-Carlos Gutierrez-Ramos Takeda (United States)
Eugene C. Butcher
Eugene C. Butcher Stanford University
Julie K. Levy
Julie K. Levy University of Florida
Alisa E. Koch
Alisa E. Koch University of Michigan–Ann Arbor
Michael R. Comeau
Michael R. Comeau Silverback Therapeutics
Guttorm Haraldsen
Guttorm Haraldsen Oslo University Hospital
Howard L. Weiner
Howard L. Weiner Harvard University

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