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Immunology
Japan
2026
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Medicine
Japan
2023

D-Index & Metrics

Immunology

D-Index
155
Citations
91761
World Ranking
105
National Ranking
8

Medicine

D-Index
155
Citations
91824
World Ranking
967
National Ranking
15

Research.com Recognitions

  • 2026 - Research.com Immunology in Japan Leader Award
  • 2025 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Immunology in Japan Leader Award
  • 2023 - Research.com Medicine in Japan Leader Award
  • 2022 - Research.com Immunology in Japan Leader Award

Overview

Kouji Matsushima is affiliated with Tokyo University of Science in Japan, focusing primarily on research in medicine, immunology, and molecular biology. Their scientific output encompasses a broad range of studies within immunology and microbiology as well as oncology and infectious diseases.

Their work covers several significant topics, including:

  • Immunotherapy and Immune Responses
  • CAR-T cell therapy research
  • Cancer Immunotherapy and Biomarkers
  • Immune Cell Function and Interaction
  • T-cell and B-cell Immunology
  • Immune cells in cancer
  • SARS-CoV-2 and COVID-19 Research

Matsushima has contributed to multiple frequent publication venues, demonstrating continued engagement with respected platforms in their fields of study. These venues include:

  • Nature Communications
  • IUPHAR/BPS Guide to Pharmacology CITE
  • The Journal of Immunology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Proceedings for Annual Meeting of The Japanese Pharmacological Society

Recent publications highlight the focus on cytokines, cancer biology, and immune system regulation. Notable papers authored or coauthored by Matsushima include:

  • Interleukin-8: An evolving chemokine, 2022, Cytokine
  • Generation of a p16 Reporter Mouse and Its Use to Characterize and Target p16high Cells In Vivo, 2020, Cell Metabolism
  • Interleukin-11-expressing fibroblasts have a unique gene signature correlated with poor prognosis of colorectal cancer, 2021, Nature Communications
  • Macrophages in lung fibrosis, 2021, International Immunology
  • Targeting FROUNT with disulfiram suppresses macrophage accumulation and its tumor-promoting properties, 2020, Nature Communications

The scientist collaborates frequently with a group of co-authors, with whom several publications have been produced. Frequent collaborators include:

  • Shigeyuki Shichino
  • Satoshi Ueha
  • Hiroyasu Aoki
  • Yuya Terashima
  • Noriko Ouji-Sageshima

The breadth of research topics and frequent publication in recognized journals suggest active involvement in advancing the understanding of immune mechanisms, cancer therapies, and cellular biology. The integration of experimental model development, such as the use of reporter mice, indicates expertise in both molecular techniques and translational approaches.

Best Publications

  • Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota

    Koji Atarashi;Takeshi Tanoue;Kenshiro Oshima;Wataru Suda

  • International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors

    Philip M. Murphy;Marco Baggiolini;Israel F. Charo;Caroline A. Hébert

  • Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

    J. J. Oppenheim;C. O. C. Zachariae;N. Mukaida;K. Matsushima

  • The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract.

    Kazunobu Tachibana;Seiichi Hirota;Hisashi Iizasa;Hisahiro Yoshida

  • There is more than one interleukin 1.

    Joost J. Oppenheim;Elizabeth J. Kovacs;Kouji Matsushima;Scott K. Durum

  • Molecular cloning of a human monocyte-derived neutrophil chemotactic factor (MDNCF) and the induction of MDNCF mRNA by interleukin 1 and tumor necrosis factor.

    Kouji Matsushima;Kazuhiro Morishita;Teizo Yoshimura;Sukadev Lavu

  • Essential involvement of interleukin-8 (IL-8) in acute inflammation.

    Akihisa Harada;Nobuaki Sekido;Tohru Akahoshi;Tohru Akahoshi;Takashi Wada

  • Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines

    Teizo Yoshimura;Kouji Matsushima;Shuji Tanaka;Elizabeth A. Robinson

  • The neutrophil-activating protein (NAP-1) is also chemotactic for T lymphocytes.

    Christian Grønhøj Larsen;Arthur O. Anderson;Ettore Appella;Joost J. Oppenheim

  • The medaka draft genome and insights into vertebrate genome evolution

    Masahiro Kasahara;Kiyoshi Naruse;Shin Sasaki;Yoichiro Nakatani

  • Purification and characterization of a novel monocyte chemotactic and activating factor produced by a human myelomonocytic cell line

    K Matsushima;C G Larsen;G C DuBois;J J Oppenheim

  • International Union of Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors

    Francoise Bachelerie;Adit Ben-Baruch;Amanda M. Burkhardt;Christophe Combadiere

  • Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokine

    Toshio Imai;Morio Nagira;Shin Takagi;Mayumi Kakizaki

  • Significance of macrophage chemoattractant protein-1 in macrophage recruitment, angiogenesis, and survival in human breast cancer.

    Takayuki Ueno;Masakazu Toi;Hisashi Saji;Mariko Muta

  • Recombinant Human Interferon-inducible Protein 10 Is a Chemoattractant for Human Monocytes and T Lymphocytes and Promotes T Cell Adhesion to Endothelial Cells

    Dennis D. Taub;Andrew R. Lloyd;Kevin Conlon;Ji Ming Wang

  • Interleukin 8 and MCAF: novel inflammatory cytokines inducible by IL 1 and TNF.

    Kouji Matsushima;Joost J. Oppenheim

  • Neutrophil chemotactic factor produced by lipopolysaccharide (LPS)-stimulated human blood mononuclear leukocytes: partial characterization and separation from interleukin 1 (IL 1).

    Teizo Yoshimura;Kouji Matsushima;Joost J Oppenheim;Edward J Leonard

  • Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

    Nobuaki Sekido;Naofumi Mukaida;Akihisa Harada;Isao Nakanishi

  • Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8.

    N Mukaida;M Shiroo;K Matsushima

  • Molecular mechanism of interleukin-8 gene expression

    Naofumi Mukaida;Shu-ichi Okamoto;Yuji Ishikawa;Kouji Matsushima

Frequent Co-Authors

Naofumi Mukaida
Naofumi Mukaida Kanazawa University
Shin-ichi Hashimoto
Shin-ichi Hashimoto Kanazawa University
Joost J. Oppenheim
Joost J. Oppenheim National Institutes of Health
Shuichi Kaneko
Shuichi Kaneko Kanazawa University
Koichi Hirai
Koichi Hirai University of Tokyo
Tadashi Kasahara
Tadashi Kasahara Jichi Medical University
Osamu Yoshie
Osamu Yoshie Kindai University
Ettore Appella
Ettore Appella National Institutes of Health
Kazuhiro Kakimi
Kazuhiro Kakimi Kindai University

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