D-Index & Metrics Best Publications
Medicine
Japan
2023

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Immunology D-index 106 Citations 35,879 349 World Ranking 329 National Ranking 12
Medicine D-index 111 Citations 39,223 403 World Ranking 3129 National Ranking 60

Research.com Recognitions

Awards & Achievements

2023 - Research.com Medicine in Japan Leader Award

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • Cytokine
  • Immune system

Naofumi Mukaida spends much of his time researching Immunology, Interleukin 8, Chemokine, Cytokine and Molecular biology. His biological study deals with issues like Neovascularization, which deal with fields such as Cancer cell. The various areas that Naofumi Mukaida examines in his Interleukin 8 study include Virology, Chemotaxis, Transfection, Northern blot and Interleukin.

Naofumi Mukaida combines subjects such as Endocrinology, Cell biology and Monocyte with his study of Chemokine. His Cytokine research incorporates elements of Tumor necrosis factor alpha, Pathology, Peptide sequence, Proinflammatory cytokine and Cell surface receptor. His Molecular biology research incorporates themes from Promoter, Gene expression, Transcription factor, Regulation of gene expression and Binding site.

His most cited work include:

  • Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family (1718 citations)
  • Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. (855 citations)
  • Essential involvement of interleukin-8 (IL-8) in acute inflammation. (759 citations)

What are the main themes of his work throughout his whole career to date?

His primary areas of study are Immunology, Cancer research, Chemokine, Molecular biology and Cytokine. His study looks at the relationship between Immunology and fields such as Chemotaxis, as well as how they intersect with chemical problems. His work deals with themes such as Pathology and Monocyte, which intersect with Chemokine.

His Molecular biology research includes themes of Regulation of gene expression, Transcription factor, Gene expression, Gene and Receptor. His Cytokine research is multidisciplinary, incorporating elements of Tumor necrosis factor alpha, Endocrinology and Proinflammatory cytokine. Naofumi Mukaida has included themes like Transfection and Virology in his Interleukin 8 study.

He most often published in these fields:

  • Immunology (38.59%)
  • Cancer research (26.21%)
  • Chemokine (28.16%)

What were the highlights of his more recent work (between 2013-2021)?

  • Cancer research (26.21%)
  • Chemokine (28.16%)
  • Cancer (6.55%)

In recent papers he was focusing on the following fields of study:

The scientist’s investigation covers issues in Cancer research, Chemokine, Cancer, Immunology and Carcinogenesis. Naofumi Mukaida has researched Cancer research in several fields, including Cancer cell, CCL3, Metastasis and Bone marrow. Naofumi Mukaida specializes in Chemokine, namely Macrophage inflammatory protein.

The study incorporates disciplines such as Gene expression profiling, Kinase activity, Pathology, Hepatocellular carcinoma and Melanoma in addition to Cancer. His research integrates issues of Cell, Interleukin 1 receptor antagonist, Receptor antagonist, Chemotherapy and Phenotype in his study of Immunology. His Inflammation study combines topics in areas such as Endocrinology, White adipose tissue, Neovascularization and Insulin resistance.

Between 2013 and 2021, his most popular works were:

  • DPP-4 Inhibition by Linagliptin Attenuates Obesity-Related Inflammation and Insulin Resistance by Regulating M1/M2 Macrophage Polarization (93 citations)
  • TNF-α/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. (72 citations)
  • Chemokines in cancer development and progression and their potential as targeting molecules for cancer treatment (67 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • Cytokine
  • Immune system

His scientific interests lie mostly in Cancer research, Carcinogenesis, Cancer, Cancer cell and Immunology. His studies deal with areas such as Growth factor, CCL3, Internal medicine and Metastasis as well as Cancer research. Naofumi Mukaida works mostly in the field of Carcinogenesis, limiting it down to topics relating to Endocrinology and, in certain cases, Macrophage.

His Cancer research integrates issues from Chemokine, Hepatocellular carcinoma, Carcinoma and Lysophosphatidic acid. His biological study spans a wide range of topics, including Pathology, M2 Macrophage and Cell biology. Many of his studies on Immunology apply to Haematopoiesis as well.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

J. J. Oppenheim;C. O. C. Zachariae;N. Mukaida;K. Matsushima.
Annual Review of Immunology (1991)

2443 Citations

Transcription factors NF-IL6 and NF-kappa B synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8.

Taiji Matsusaka;Keiko Fujikawa;Yukihiro Nishio;Naofumi Mukaida.
Proceedings of the National Academy of Sciences of the United States of America (1993)

1393 Citations

Essential involvement of interleukin-8 (IL-8) in acute inflammation.

Akihisa Harada;Nobuaki Sekido;Tohru Akahoshi;Tohru Akahoshi;Takashi Wada.
Journal of Leukocyte Biology (1994)

1305 Citations

Descemet membrane endothelial keratoplasty (DMEK).

Peirong Lu;Longbiao Li;Naofumi Mukaida;Xueguang Zhang.
Cornea (2007)

1044 Citations

Blocking TNF-α in mice reduces colorectal carcinogenesis associated with chronic colitis

Boryana K. Popivanova;Kazuya Kitamura;Yu Wu;Toshikazu Kondo.
Journal of Clinical Investigation (2008)

960 Citations

Cooperative interaction of nuclear factor-kappa B- and cis-regulatory enhancer binding protein-like factor binding elements in activating the interleukin-8 gene by pro-inflammatory cytokines.

N Mukaida;Y Mahe;K Matsushima.
Journal of Biological Chemistry (1990)

924 Citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

Nobuaki Sekido;Naofumi Mukaida;Akihisa Harada;Isao Nakanishi.
Nature (1993)

826 Citations

Genomic structure of the human monocyte-derived neutrophil chemotactic factor IL-8.

N Mukaida;M Shiroo;K Matsushima.
Journal of Immunology (1989)

721 Citations

Molecular mechanism of interleukin-8 gene expression

Naofumi Mukaida;Shu-ichi Okamoto;Yuji Ishikawa;Kouji Matsushima.
Journal of Leukocyte Biology (1994)

680 Citations

Tumor necrosis factor alpha and interferon gamma synergistically induce interleukin 8 production in a human gastric cancer cell line through acting concurrently on AP-1 and NF-kB-like binding sites of the interleukin 8 gene.

Kazuo Yasumoto;Shu Ichi Okamoto;Naofumi Mukaida;Seishi Murakami.
Journal of Biological Chemistry (1992)

639 Citations

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