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Atsushi Hirao

Atsushi Hirao

D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
20422
World Ranking
13543
National Ranking
947

Overview

Atsushi Hirao is a researcher affiliated with Kanazawa University in Japan. Their work spans across the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, with significant contributions focused on Molecular Biology, Hematology, Immunology, Oncology, and Genetics.

The research topics most frequently covered in their publications include:

  • Acute Myeloid Leukemia Research
  • Glioma Diagnosis and Treatment
  • Immune Cell Function and Interaction
  • Protein Degradation and Inhibitors
  • Epigenetics and DNA Methylation
  • Autophagy in Disease and Therapy
  • Cancer, Hypoxia, and Metabolism

Their recent papers demonstrate a focus on cancer biology, cellular metabolism, and immune cell function. Notable publications include:

  • "CDK8 maintains stemness and tumorigenicity of glioma stem cells by regulating the c-MYC pathway" (2021, Oncogene)
  • "Inhibition of the mitochondria-shaping protein Opa1 restores sensitivity to Gefitinib in a lung adenocarcinoma-resistant cell line" (2023, Cell Death and Disease)
  • "Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes" (2022, iScience)
  • "Niacin restriction with NAMPT-inhibition is synthetic lethal to neuroendocrine carcinoma" (2023, Nature Communications)
  • "SMURF2 phosphorylation at Thr249 modifies glioma stemness and tumorigenicity by regulating TGF-β receptor stability" (2022, Communications Biology)

Frequent co-authors collaborating with Atsushi Hirao include:

  • Masaya Ueno
  • Masahiko Kobayashi
  • Tomoki Todo
  • Mitsutoshi Nakada
  • Kazuya Fukasawa

The venues where Hirao regularly publishes research reflect their areas of focus. These include:

  • Cancer Science
  • Cell Death and Disease
  • Nature Communications
  • Communications Biology
  • Cancer Research Communications

Best Publications

  • Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche

    Fumio Arai;Atsushi Hirao;Masako Ohmura;Hidetaka Sato

  • DNA damage-induced activation of p53 by the checkpoint kinase Chk2.

    Atsushi Hirao;Young-Yun Kong;Shuhei Matsuoka;Andrew Wakeham

  • Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.

    Keisuke Ito;Atsushi Hirao;Atsushi Hirao;Fumio Arai;Keiyo Takubo

  • Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells

    Keisuke Ito;Atsushi Hirao;Fumio Arai;Sahoko Matsuoka

  • Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.

    Yoshinobu Ichimura;Satoshi Waguri;Yu shin Sou;Shun Kageyama

  • Regulation of the HIF-1α level is essential for hematopoietic stem cells

    Keiyo Takubo;Nobuhito Goda;Wakako Yamada;Hirono Iriuchishima

  • Foxo3a is essential for maintenance of the hematopoietic stem cell pool.

    Kana Miyamoto;Kiyomi Y. Araki;Kazuhito Naka;Fumio Arai

  • Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

    Keiyo Takubo;Go Nagamatsu;Chiharu I. Kobayashi;Ayako Nakamura-Ishizu

  • TGF-β-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia

    Kazuhito Naka;Takayuki Hoshii;Teruyuki Muraguchi;Yuko Tadokoro

  • ERK Activation Mediates Cell Cycle Arrest and Apoptosis after DNA Damage Independently of p53

    Damu Tang;Dongcheng Wu;Atsushi Hirao;Jill M. Lahti

  • Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

    Atsushi Hirao;Alison Cheung;Gordon Duncan;Pierre Marie Girard

  • Activated macrophages promote Wnt signalling through tumour necrosis factor‐α in gastric tumour cells

    Keisuke Oguma;Hiroko Oshima;Masahiro Aoki;Ryusei Uchio

  • PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ.

    Yutaka Kurebayashi;Shigenori Nagai;Ai Ikejiri;Masashi Ohtani

  • Hematopoietic stem cells and their niche.

    Toshio Suda;Fumio Arai;Atsushi Hirao

  • Regulation of Reactive Oxygen Species and Genomic Stability in Hematopoietic Stem Cells

    Kazuhito Naka;Teruyuki Muraguchi;Takayuki Hoshii;Atsushi Hirao

  • Metabolic regulation of osteoclast differentiation and function.

    Yoriko Indo;Sunao Takeshita;Kiyo-Aki Ishii;Takayuki Hoshii

  • Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.

    Kimi Yamakoshi;Akiko Takahashi;Fumiko Hirota;Rika Nakayama

  • Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

    Melissa T. Jack;Richard A. Woo;Atsushi Hirao;Alison Cheung

  • Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence

    Shoichiro Takeishi;Akinobu Matsumoto;Ichiro Onoyama;Kazuhito Naka

  • Erratum: PI3K-Akt-mTORC1-S6K1/2 axis controls Th17 differentiation by regulating Gfi1 expression and nuclear translocation of RORγ (PI3K-Akt-mTORC1-S6K1/2 Axis Controls Th17 Differentiation by Regulating Gfi1 Expression and Nuclear Translocation of RORγ (2012) 1(4) (360–373), (S2211124712000642), (10.1016/j.celrep.2012.02.007))

    Yutaka Kurebayashi;Shigenori Nagai;Ai Ikejiri;Masashi Ohtani

Frequent Co-Authors

Toshio Suda
Toshio Suda National University of Singapore
Fumio Arai
Fumio Arai Kyushu University
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre
Hideyuki Saya
Hideyuki Saya Fujita Health University
Eiji Hara
Eiji Hara Osaka University
Tomoki Todo
Tomoki Todo University of Tokyo
Yasuo Ikeda
Yasuo Ikeda Waseda University
Naoko Ohtani
Naoko Ohtani Osaka Metropolitan University
Andrew Wakeham
Andrew Wakeham Princess Margaret Cancer Centre
Tak W. Mak
Tak W. Mak Princess Margaret Cancer Centre

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