The scientist’s investigation covers issues in Cell biology, Cancer research, CD44, Molecular biology and Mitosis. His studies in Cell biology integrate themes in fields like Ectodomain, Mitotic exit, Cell cycle and Cytokinesis. He combines subjects such as Carcinogenesis, Endocrinology, Internal medicine and Immunology with his study of Cancer research.
His CD44 study integrates concerns from other disciplines, such as Cancer cell, Cancer stem cell, Pathology, Metastasis and Extracellular matrix. His studies deal with areas such as DNA damage, DNA methylation, Methyl-CpG-binding domain, Small interfering RNA and Secretion as well as Molecular biology. His Mitosis research integrates issues from Prometaphase, Microtubule, Centrosome and Aurora B kinase.
His scientific interests lie mostly in Cancer research, Cell biology, Molecular biology, CD44 and Cancer stem cell. As a part of the same scientific family, Hideyuki Saya mostly works in the field of Cancer research, focusing on Cancer cell and, on occasion, Metastasis. His research in Cell biology intersects with topics in Cell cycle and Cell cycle checkpoint.
His study focuses on the intersection of Molecular biology and fields such as Cell culture with connections in the field of Cell growth. His CD44 research is multidisciplinary, incorporating perspectives in Tumor progression, Internal medicine and Pathology. Cancer stem cell is a primary field of his research addressed under Stem cell.
Hideyuki Saya mostly deals with Cancer research, Cell biology, Cancer stem cell, Stem cell and Glioma. The Cancer research study combines topics in areas such as Cell, Cisplatin, Cancer cell, Sulfasalazine and Cytotoxic T cell. His work deals with themes such as Phenotype, Cell cycle and Meiosis II, which intersect with Cell biology.
The study incorporates disciplines such as Radiation therapy, CD44, Progenitor cell, Epithelial cell adhesion molecule and Mesenchymal stem cell in addition to Cancer stem cell. His research integrates issues of Surface marker, Alternative splicing, Gene isoform, Molecular biology and Internal medicine in his study of CD44. As part of the same scientific family, he usually focuses on Stem cell, concentrating on Downregulation and upregulation and intersecting with Cell growth, Inhibitor of apoptosis, Picropodophyllin and Wnt signaling pathway.
Hideyuki Saya focuses on Cancer research, Cancer stem cell, Cancer cell, CD44 and Cytotoxic T cell. His biological study spans a wide range of topics, including Progenitor cell, Epigenetics, Metastasis and Cisplatin. His Cancer cell study incorporates themes from Brain metastasis, Glutathione, Targeted therapy, Ovarian cancer and Adipose tissue.
His CD44 study combines topics in areas such as Chromatin immunoprecipitation, Alternative splicing, Molecular biology, Histone H3 acetylation and Sulfasalazine. His work in Carcinogenesis tackles topics such as Transcription which are related to areas like Cell biology. His Cell biology research incorporates themes from Cell culture and Cell growth.
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Aurora-A — A guardian of poles
Tomotoshi Marumoto;Dongwei Zhang;Hideyuki Saya.
Nature Reviews Cancer (2005)
CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth
Takatsugu Ishimoto;Osamu Nagano;Toshifumi Yae;Mayumi Tamada.
Cancer Cell (2011)
Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells
Toru Hirota;Toru Hirota;Toru Hirota;Naoko Kunitoku;Takashi Sasayama;Tomotoshi Marumoto.
Cell (2003)
Prognostic Value of Epidermal Growth Factor Receptor in Patients with Glioblastoma Multiforme
Naoki Shinojima;Kenji Tada;Shoji Shiraishi;Takanori Kamiryo.
Cancer Research (2003)
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.
Akiko Takahashi;Naoko Ohtani;Kimi Yamakoshi;Shin Ichi Iida.
Nature Cell Biology (2006)
Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells
Tomotoshi Marumoto;Tomotoshi Marumoto;Shinobu Honda;Toshihiro Hara;Masayuki Nitta.
Journal of Biological Chemistry (2003)
Mechanism and biological significance of CD44 cleavage
Osamu Nagano;Hideyuki Saya.
Cancer Science (2004)
Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway
Isamu Okamoto;Isamu Okamoto;Yoshiaki Kawano;Daizo Murakami;Takashi Sasayama.
Journal of Cell Biology (2001)
Expression of CD44R1 adhesion molecule in colon carcinomas and metastases.
K. K. Tanabe;Lee M Ellis;Hideyuki Saya.
The Lancet (1993)
Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation
Osamu Nagano;Daizo Murakami;Dieter Hartmann;Bart De Strooper.
Journal of Cell Biology (2004)
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