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Genetics and Molecular Biology
Japan
2024

D-Index & Metrics

Molecular Biology

D-Index
107
Citations
38125
World Ranking
417
National Ranking
29

Medicine

D-Index
108
Citations
39501
World Ranking
6044
National Ranking
134

Research.com Recognitions

  • 2024 - Research.com Genetics and Molecular Biology in Japan Leader Award

Overview

Hideyuki Saya is affiliated with Keio University in Japan and has contributed extensively to the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their research spans numerous specialized areas, including Molecular Biology, Oncology, Infectious Diseases, Cancer Research, and Surgery.

The primary research topics covered by their work include:

  • SARS-CoV-2 and COVID-19 Research
  • Cancer Cells and Metastasis
  • COVID-19 Clinical Research Studies
  • Pancreatic and Hepatic Oncology Research
  • SARS-CoV-2 detection and testing
  • Glioma Diagnosis and Treatment
  • Cancer, Hypoxia, and Metabolism

Recent significant publications by Hideyuki Saya include:

  • "Molecular and cellular mechanisms underlying brain metastasis of breast cancer" (2020), published in Cancer and Metastasis Reviews
  • "N-cadherin upregulation mediates adaptive radioresistance in glioblastoma" (2021), published in Journal of Clinical Investigation
  • "Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti-PD-1 Immunotherapy in Fibrotic Tumors" (2022), published in Cancer Research
  • "TGFβ Signaling Activated by Cancer-Associated Fibroblasts Determines the Histological Signature of Lung Adenocarcinoma" (2021), published in Cancer Research
  • "IDH2 stabilizes HIF-1α-induced metabolic reprogramming and promotes chemoresistance in urothelial cancer" (2023), published in The EMBO Journal

The scientist has frequently published in the following venues:

  • Cancer Research
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Neuro-Oncology Advances
  • Cancer Science
  • Scientific Reports

Frequent collaborators include:

  • Oltea Sampetrean
  • Eiji Sugihara
  • Yoshifumi Uwamino
  • Mitsuru Murata
  • Naoki Hasegawa

Best Publications

  • CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

    Takatsugu Ishimoto;Osamu Nagano;Toshifumi Yae;Mayumi Tamada

  • Aurora-A — A guardian of poles

    Tomotoshi Marumoto;Dongwei Zhang;Hideyuki Saya

  • Aurora-A and an Interacting Activator, the LIM Protein Ajuba, Are Required for Mitotic Commitment in Human Cells

    Toru Hirota;Toru Hirota;Toru Hirota;Naoko Kunitoku;Takashi Sasayama;Tomotoshi Marumoto

  • Prognostic Value of Epidermal Growth Factor Receptor in Patients with Glioblastoma Multiforme

    Naoki Shinojima;Kenji Tada;Shoji Shiraishi;Takanori Kamiryo

  • Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence.

    Akiko Takahashi;Naoko Ohtani;Kimi Yamakoshi;Shin Ichi Iida

  • Modeling sporadic ALS in iPSC-derived motor neurons identifies a potential therapeutic agent.

    Koki Fujimori;Mitsuru Ishikawa;Asako Otomo;Naoki Atsuta

  • Mechanism and biological significance of CD44 cleavage

    Osamu Nagano;Hideyuki Saya

  • Aurora-A Kinase Maintains the Fidelity of Early and Late Mitotic Events in HeLa Cells

    Tomotoshi Marumoto;Tomotoshi Marumoto;Shinobu Honda;Toshihiro Hara;Masayuki Nitta

  • Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway

    Isamu Okamoto;Isamu Okamoto;Yoshiaki Kawano;Daizo Murakami;Takashi Sasayama

  • M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

    Yoshiaki Kubota;Keiyo Takubo;Takatsune Shimizu;Hiroaki Ohno

  • Expression of CD44R1 adhesion molecule in colon carcinomas and metastases.

    K. K. Tanabe;Lee M Ellis;Hideyuki Saya

  • Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

    Toshifumi Yae;Toshifumi Yae;Kenji Tsuchihashi;Takatsugu Ishimoto;Takeshi Motohara

  • Hair follicle-derived IL-7 and IL-15 mediate skin-resident memory T cell homeostasis and lymphoma.

    Takeya Adachi;Tetsuro Kobayashi;Tetsuro Kobayashi;Eiji Sugihara;Taketo Yamada

  • High-Efficiency in Vivo Gene Transfer Using Intraarterial Plasmid DNA Injection following in Vivo Electroporation

    Toru Nishi;Kimio Yoshizato;Shigeo Yamashiro;Hideo Takeshima

  • Activated macrophages promote Wnt signalling through tumour necrosis factor‐α in gastric tumour cells

    Keisuke Oguma;Hiroko Oshima;Masahiro Aoki;Ryusei Uchio

  • Evidence for p53-Mediated Modulation of Neuronal Viability

    Hong Xiang;Daryl W. Hochman;Hideyuki Saya;Toshiyoshi Fujiwara

  • CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration.

    Isamu Okamoto;Yoshiaki Kawano;Hiromasa Tsuiki;Ji Ichiro Sasaki

  • Cell–matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extracellular Ca2+ influx and PKC activation

    Osamu Nagano;Daizo Murakami;Dieter Hartmann;Bart De Strooper

  • Redox regulation in stem-like cancer cells by CD44 variant isoforms

    O Nagano;S Okazaki;H Saya

  • CENP-A Phosphorylation by Aurora-A in Prophase Is Required for Enrichment of Aurora-B at Inner Centromeres and for Kinetochore Function

    Naoko Kunitoku;Takashi Sasayama;Tomotoshi Marumoto;Dongwei Zhang

Frequent Co-Authors

Mitsuyoshi Nakao
Mitsuyoshi Nakao Kumamoto University
Makoto Suematsu
Makoto Suematsu Keio University
Yuko Kitagawa
Yuko Kitagawa Keio University
Hideyuki Okano
Hideyuki Okano Keio University
Isamu Okamoto
Isamu Okamoto Kyushu University
Victor A. Levin
Victor A. Levin The University of Texas MD Anderson Cancer Center
Naoto T. Ueno
Naoto T. Ueno University of Hawaiʻi Cancer Center
Atsushi Hirao
Atsushi Hirao Kanazawa University
Yumi Matsuzaki
Yumi Matsuzaki Shimane University
Yutaka Kawakami
Yutaka Kawakami International University Of Health And Welfare Atami Hospital

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