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Biology and Biochemistry

D-Index
64
Citations
14311
World Ranking
9693
National Ranking
4272

Overview

Leonard H. Rome is affiliated with the University of California, Los Angeles in the United States. Their research primarily focuses on the fields of Biochemistry, Genetics, and Molecular Biology, with specific subfields including Molecular Biology, Immunology, Genetics, Plant Science, and Biotechnology.

The scientist's work covers several main topics such as enzyme-mediated dye degradation, immunotherapy and immune responses, RNA interference and gene delivery, extracellular vesicles in disease, microRNA in disease regulation, RNA modifications and cancer, and microbial metabolism and applications.

Recent papers authored by Leonard H. Rome include the following:

  • Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets (2021, Nature Cell Biology)
  • Immobilized fungal enzymes: Innovations and potential applications in biodegradation and biosynthesis (2022, Biotechnology Advances)
  • Decolorization and detoxification of synthetic dye compounds by laccase immobilized in vault nanoparticles (2022, Bioresource Technology)
  • Intratumor injection of CCL21-coupled vault nanoparticles is associated with reduction in tumor volume in an in vivo model of glioma (2020, Journal of Neuro-Oncology)
  • Immunoediting role for major vault protein in apoptotic signaling induced by bacterial N-acyl homoserine lactones (2021, Proceedings of the National Academy of Sciences)

The frequent co-authors collaborating with Leonard H. Rome include Valerie A. Kickhoefer, Meng Wang, Shaily Mahendra, Yifan Gao, and Brittany Voth.

Leonard H. Rome's research has been published in several recurring venues, including:

  • Journal of Neuro-Oncology
  • Nature Cell Biology
  • Bioresource Technology
  • Biotechnology Advances
  • Proceedings of the National Academy of Sciences

Best Publications

  • Reassessment of Exosome Composition

    Dennis K. Jeppesen;Aidan M. Fenix;Jeffrey L. Franklin;James N. Higginbotham

  • The 193-Kd Vault Protein, Vparp, Is a Novel Poly(Adp-Ribose) Polymerase

    Valerie A. Kickhoefer;Amara C. Siva;Nancy L. Kedersha;Elisabeth M. Inman

  • Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs.

    Leonard H. Rome;William E. M. Lands

  • Isolation and characterization of a novel ribonucleoprotein particle: large structures contain a single species of small RNA.

    Nancy L. Kedersha;Leonard H. Rome

  • Inhibition of Prostaglandin Biosynthesis

    W. E. M. Lands;L. H. Rome

  • Two species of lysosomal organelles in cultured human fibroblasts

    Leonard H. Rome;A. Julian Garvin;Margaretta M. Allietta;Elizabeth F. Neufeld

  • Vaults are up-regulated in multidrug-resistant cancer cell lines

    Valerie A. Kickhoefer;Kavitha S. Rajavel;George L. Scheffer;William S. Dalton

  • Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex

    Diane C. Chugani;Leonard H. Rome;Nancy L. Kedersha

  • The transport of lysosomal enzymes.

    Elizabeth F. Neufeld;Gloria N. Sando;A. Julian Garvin;Leonard H. Rome

  • Vaults. III. Vault ribonucleoprotein particles open into flower-like structures with octagonal symmetry.

    Nancy L. Kedersha;John E. Heuser;Diane C. Chugani;Leonard H. Rome

  • Vaults and Telomerase Share a Common Subunit, TEP1

    Valerie A. Kickhoefer;Andrew G. Stephen;Lea Harrington;Murray O. Robinson

  • Vaults. II. Ribonucleoprotein structures are highly conserved among higher and lower eukaryotes.

    N L Kedersha;M C Miquel;D Bittner;L H Rome

  • Sizing Large Proteins and Protein Complexes by Electrospray Ionization Mass Spectrometry and Ion Mobility

    Catherine S. Kaddis;Shirley H. Lomeli;Sheng Yin;Beniam Berhane

  • Assembly of Vault-like Particles in Insect Cells Expressing Only the Major Vault Protein

    Andrew G. Stephen;Sujna Raval-Fernandes;Thu Huynh;Michael Torres

  • Structure of the vault, a ubiquitous celular component

    Lawrence B Kong;Amara C Siva;Leonard H Rome;Phoebe L Stewart

  • Direct demonstration of binding of a lysosomal enzyme, alpha-L-iduronidase, to receptors on cultured fibroblasts.

    Leonard H. Rome;Bernard Weissmann;Elizabeth F. Neufeld

  • Vault ribonucleoprotein particles from rat and bullfrog contain a related small RNA that is transcribed by RNA polymerase III.

    V A Kickhoefer;R P Searles;N L Kedersha;M E Garber

  • Engineering of vault nanocapsules with enzymatic and fluorescent properties

    Valerie A. Kickhoefer;Yvette Garcia;Yeshi Mikyas;Erik Johansson

  • Unlocking vaults: organelles in search of a function

    Leonard Rome;Nancy Kedersha;Diane Chugani

  • Targeting Vault Nanoparticles to Specific Cell Surface Receptors

    Valerie A. Kickhoefer;Muri Han;Sujna Raval-Fernandes;Michael J. Poderycki

Frequent Co-Authors

Nancy Kedersha
Nancy Kedersha Harvard University
Phoebe L. Stewart
Phoebe L. Stewart Case Western Reserve University
Lucia Notterpek
Lucia Notterpek University of Florida
Otto O. Yang
Otto O. Yang University of California, Los Angeles
Elizabeth F. Neufeld
Elizabeth F. Neufeld University of California, Los Angeles
Diane C. Chugani
Diane C. Chugani Wayne State University
Z. Hong Zhou
Z. Hong Zhou University of California, Los Angeles
Heather D. Maynard
Heather D. Maynard University of California, Los Angeles
Sarah H. Tolbert
Sarah H. Tolbert University of California, Los Angeles
Jeffrey I. Zink
Jeffrey I. Zink University of California, Los Angeles

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