His primary areas of investigation include Biochemistry, Cyclooxygenase, Enzyme, Prostaglandin and Pharmacology. Many of his studies on Biochemistry involve topics that are commonly interrelated, such as Molecular biology. His Cyclooxygenase study integrates concerns from other disciplines, such as Central nervous system, Microglia, Immune system, Pathology and Isozyme.
His study in the field of Lipid peroxidation also crosses realms of Leukotriene. The Prostaglandin study combines topics in areas such as Protein primary structure, Serine, Arachidonic acid, Complementary DNA and Regulation of gene expression. His work carried out in the field of Pharmacology brings together such families of science as Inflammation, Aspirin and Toxicity.
David L. DeWitt mainly investigates Biochemistry, Cyclooxygenase, Enzyme, Molecular biology and Prostaglandin. David L. DeWitt has researched Cyclooxygenase in several fields, including Fruit extracts, Traditional medicine and Pharmacology. His study looks at the relationship between Pharmacology and topics such as Aspirin, which overlap with Ibuprofen.
His Enzyme research is multidisciplinary, incorporating elements of Transcriptional regulation, Prostanoid and Cytotoxicity. He interconnects Prostaglandin E2, Endocrinology, Internal medicine, Endoplasmic reticulum and Peptide sequence in the investigation of issues within Molecular biology. His biological study spans a wide range of topics, including Gene, Biosynthesis, Stimulation, Monocyte and Cell biology.
His scientific interests lie mostly in Biochemistry, Lipid peroxidation, Cyclooxygenase, Enzyme and Traditional medicine. Cell growth, IC50, Linoleic acid, Prostaglandin and Arachidonic acid are among the areas of Biochemistry where the researcher is concentrating his efforts. David L. DeWitt works mostly in the field of Prostaglandin, limiting it down to topics relating to Matrix metalloproteinase and, in certain cases, Molecular biology, as a part of the same area of interest.
His research integrates issues of Inhibitory postsynaptic potential, Nonsteroidal, Prostaglandin endoperoxide and Glycosphingolipid in his study of Cyclooxygenase. He combines subjects such as Integral membrane protein and Biophysics with his study of Enzyme. His Traditional medicine research integrates issues from Fruit extracts, Inflammation and Pharmacognosy.
His main research concerns Biochemistry, Enzyme, Enzyme assay, Cell growth and IC50. His studies in Biochemistry integrate themes in fields like Agrocybe, Pharmacology and Black poplar. Particularly relevant to Cyclooxygenase is his body of work in Enzyme.
The various areas that David L. DeWitt examines in his Cyclooxygenase study include Lipid peroxidation and Antioxidant. His work deals with themes such as Angiogenesis, Docking, Arachidonic acid, Lipoxygenase and Biological activity, which intersect with Cell growth. His IC50 research is multidisciplinary, relying on both Mushroom, Edible mushroom, Anti-inflammatory and Linoleic acid.
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Cyclooxygenases: Structural, cellular, and molecular biology
W. L. Smith;D. L. DeWitt;R. M. Garavito.
Annual Review of Biochemistry (2000)
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
Smith Wl;Garavito Rm;DeWitt Dl.
Journal of Biological Chemistry (1996)
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Elizabeth A. Meade;William L. Smith;David L. DeWitt.
Journal of Biological Chemistry (1993)
Antioxidant and antiinflammatory activities of anthocyanins and their aglycon, cyanidin, from tart cherries
Haibo Wang;M. G. Nair;G. M. Strasburg;Y.-C. Chang.
Journal of Natural Products (1999)
Prostaglandin endoperoxide H synthases-1 and -2.
William L. Smith;David L. Dewitt.
Advances in Immunology (1996)
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
David L. Dewitt;William L. Smith.
Proceedings of the National Academy of Sciences of the United States of America (1988)
Prostaglandin endoperoxide synthase: regulation of enzyme expression.
David L. DeWitt.
Biochimica et Biophysica Acta (1991)
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
Ikuo Morita;Melvin Schindler;Martha K. Regier;James C. Otto.
Journal of Biological Chemistry (1995)
Characterization of inducible cyclooxygenase in rat brain
Christopher D. Breder;David Dewitt;Richard P. Kraig.
The Journal of Comparative Neurology (1995)
Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs.
O Laneuville;D K Breuer;D L Dewitt;T Hla.
Journal of Pharmacology and Experimental Therapeutics (1994)
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