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Biology and Biochemistry

D-Index
55
Citations
9233
World Ranking
15216
National Ranking
6361

Overview

Yeon-Kyun Shin is affiliated with Iowa State University in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with additional contributions in medicine. The scientist's work spans several subfields including cell biology, molecular biology, neurology, cellular and molecular neuroscience, and physiology.

The primary topics of their research include cellular transport and secretion, lipid membrane structure and behavior, Parkinson's disease mechanisms and treatments, neuroscience and neuropharmacology research, Alzheimer's disease research and treatments, endoplasmic reticulum stress and disease, and advanced fluorescence microscopy techniques.

Yeon-Kyun Shin has published multiple scientific papers, many of which address the molecular mechanisms involved in synaptic vesicle fusion and related cellular processes. Important recent papers include:

  • The Role of α-Synuclein in SNARE-mediated Synaptic Vesicle Fusion, 2022, Journal of Molecular Biology
  • Cooperative inhibition of SNARE-mediated vesicle fusion by α-synuclein monomers and oligomers, 2021, Scientific Reports
  • Membrane Binding of α-Synuclein Stimulates Expansion of SNARE-Dependent Fusion Pore, 2021, Frontiers in Cell and Developmental Biology
  • Munc18-1 induces conformational changes of syntaxin-1 in multiple intermediates for SNARE assembly, 2020, Scientific Reports
  • Stabilization of the SNARE Core by Complexin-1 Facilitates Fusion Pore Expansion, 2021, Frontiers in Molecular Biosciences

Their studies have been featured in several publication venues, including:

  • Scientific Reports
  • Journal of Molecular Biology
  • Frontiers in Cell and Developmental Biology
  • Frontiers in Molecular Biosciences
  • Nature Communications

Frequent collaborators with Yeon-Kyun Shin include Gyeongji Yoo, Nam Ki Lee, Josh Pierson, Sanghun Yeou, and Jung Bae Son.

Best Publications

  • The synaptic SNARE complex is a parallel four-stranded helical bundle.

    Michelle A. Poirier;Wenzhong Xiao;Jed C. Macosko;Charles Chan

  • Determination of the distance between two spin labels attached to a macromolecule.

    Mark D. Rabenstein;Yeon-Kyun Shin

  • A piston model for transmembrane signaling of the aspartate receptor.

    Karen M. Ottemann;Wenzhong Xiao;Yeon-Kyun Shin;Daniel E. Koshland

  • Large α-synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

    Bong-Kyu Choi;Mal-Gi Choi;Jae-Yeol Kim;Yoosoo Yang;Yoosoo Yang

  • Hemifusion in SNARE-mediated membrane fusion.

    Yibin Xu;Fan Zhang;Zengliu Su;James A McNew

  • Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.

    Johanna R Schaub;Xiaobing Lu;Blair Doneske;Yeon-Kyun Shin

  • Multiple intermediates in SNARE-induced membrane fusion

    Tae Young Yoon;Burak Okumus;Fan Zhang;Yeon Kyun Shin

  • Colicin E1 binding to membranes: time-resolved studies of spin-labeled mutants

    Yeon-Kyun Shin;Cyrus Levinthal;Françoise Levinthal;Wayne L. Hubbell

  • Regulation of neuronal SNARE assembly by the membrane.

    Dae-Hyuk Kweon;Chang Sup Kim;Chang Sup Kim;Yeon-Kyun Shin

  • Complexin and Ca2+ stimulate SNARE-mediated membrane fusion

    Tae Young Yoon;Tae Young Yoon;Xiaobing Lu;Jiajie Diao;Soo Min Lee

  • The membrane topology of the fusion peptide region of influenza hemagglutinin determined by spin-labeling EPR

    Jed C. Macosko;Chul-Hyun Kim;Yeon-Kyun Shin

  • Dynamic Ca2+-dependent stimulation of vesicle fusion by membrane-anchored synaptotagmin 1.

    Han-Ki Lee;Yoosoo Yang;Zengliu Su;Changbong Hyeon

  • Membrane Fusion Induced by Neuronal SNAREs Transits through Hemifusion

    Xiaobing Lu;Fan Zhang;James A. McNew;Yeon-Kyun Shin

  • The neuronal t-SNARE complex is a parallel four-helix bundle

    Wenzhong Xiao;Michelle A. Poirier;Michelle A. Poirier;Mark K. Bennett;Yeon Kyun Shin

  • Insertion of a coiled-coil peptide from influenza virus hemagglutinin into membranes

    Yeon Gyu Yu;David S. King;Yeon-Kyun Shin

  • A scissors mechanism for stimulation of SNARE-mediated lipid mixing by cholesterol

    Jiansong Tong;Peter P. Borbat;Jack H. Freed;Yeon-Kyun Shin

  • Transient channel-opening in bacteriorhodopsin: an EPR study.

    Thorgeir E. Thorgeirsson;Wenzhong Xiao;Leonid S. Brown;Richard Needleman

  • A single vesicle-vesicle fusion assay for in vitro studies of SNAREs and accessory proteins

    Jiajie Diao;Yuji Ishitsuka;Hanki Lee;Chirlmin Joo

  • Biochemical and biophysical characterization of the trimerization domain from the heat shock transcription factor.

    Ralph Peteranderl;Mark Rabenstein;Yeon-Kyun Shin;Corey W. Liu

  • A peptide from the heptad repeat of human immunodeficiency virus gp41 shows both membrane binding and coiled-coil formation.

    Mark Rabenstein;Yeon-Kyun Shin

Frequent Co-Authors

Taekjip Ha
Taekjip Ha Johns Hopkins University
Wenzhong Xiao
Wenzhong Xiao Harvard University
David L. DeWitt
David L. DeWitt Michigan State University
Wayne L. Hubbell
Wayne L. Hubbell University of California, Los Angeles
Charles J. Russell
Charles J. Russell St. Jude Children's Research Hospital
James A. McNew
James A. McNew Rice University
Sydney Kustu
Sydney Kustu University of California, Berkeley
David S. King
David S. King University of California, Berkeley
Daniel E. Koshland
Daniel E. Koshland University of California, Berkeley
Richard M. Epand
Richard M. Epand McMaster University

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