World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
42
Citations
11793
World Ranking
3000
National Ranking
1425

Overview

James A. McNew is affiliated with Rice University in the United States. Their research spans the fields of Biochemistry, Genetics and Molecular Biology, and Medicine, focusing on molecular biology and related subfields such as Epidemiology, Cell Biology, Physiology, and Cellular and Molecular Neuroscience.

The scientist's work concentrates on topics including Autophagy in Disease and Therapy, Ubiquitin and proteasome pathways, Cellular transport and secretion, Genomics and Chromatin Dynamics, RNA Research and Splicing, Peroxisome Proliferator-Activated Receptors, and Mitochondrial Function and Pathology.

Recent papers by James A. McNew demonstrate a focus on cellular mechanisms and molecular pathways:

  • A transition to degeneration triggered by oxidative stress in degenerative disorders, 2020, Molecular Psychiatry
  • The Drosophila melanogaster attP40 docking site and derivatives are insertion mutations of msp-300, 2022, PLoS ONE
  • Atl (atlastin) regulates mTor signaling and autophagy in Drosophila muscle through alteration of the lysosomal network, 2023, Autophagy
  • The Drosophila attP40 docking site and derivatives are insertion mutations of MSP300, 2022, bioRxiv (Cold Spring Harbor Laboratory)
  • Human astrovirus capsid protein releases a membrane lytic peptide upon trypsin maturation, 2023, Journal of Virology

Frequent co-authors collaborating with James A. McNew include Michael Stern, Kevin van der Graaf, Saurabh Srivastav, Pratibha Singh, and Miguel A. Betancourt-Solis. The collaboration with these researchers is reflected in multiple publications and active engagement in related research areas.

The scientist has published multiple articles in venues such as PLoS ONE, bioRxiv (Cold Spring Harbor Laboratory), Molecular Psychiatry, Autophagy, and Journal of Virology. The distribution of publications across these journals highlights involvement in molecular and cellular biology, neuroscience, and virology research communities.

Best Publications

  • SNAREpins: Minimal Machinery for Membrane Fusion

    Thomas Weber;Boris V Zemelman;James A McNew;Benedikt Westermann

  • Compartmental specificity of cellular membrane fusion encoded in SNARE proteins

    James A. McNew;Francesco Parlati;Ryouichi Fukuda;Robert J. Johnston

  • SNARE proteins are required for macroautophagy

    Usha Nair;Anjali Jotwani;Jiefei Geng;Noor Gammoh

  • Homotypic fusion of ER membranes requires the dynamin-like GTPase Atlastin

    Genny Orso;Diana Pendin;Song Liu;Jessica Tosetto

  • An oligomeric protein is imported into peroxisomes in vivo

    James A. McNew;Joel M. Goodman

  • Close is not enough: SNARE-dependent membrane fusion requires an active mechanism that transduces force to membrane anchors.

    James A. McNew;Thomas Weber;Francesco Parlati;Robert J. Johnston

  • Rapid and efficient fusion of phospholipid vesicles by the alpha-helical core of a SNARE complex in the absence of an N-terminal regulatory domain

    Francesco Parlati;Thomas Weber;James A. McNew;Benedikt Westermann

  • Functional architecture of an intracellular membrane t-SNARE

    Ryouichi Fukuda;James A. McNew;James A. McNew;Thomas Weber;Thomas Weber;Francesco Parlati

  • Ykt6p, a Prenylated SNARE Essential for Endoplasmic Reticulum-Golgi Transport

    James A. McNew;Morten Søgaard;Nina M. Lampen;Sachiko Machida

  • Hemifusion in SNARE-mediated membrane fusion.

    Yibin Xu;Fan Zhang;Zengliu Su;James A McNew

  • Hemifusion arrest by complexin is relieved by Ca2+-synaptotagmin I.

    Johanna R Schaub;Xiaobing Lu;Blair Doneske;Yeon-Kyun Shin

  • Regulation of membrane fusion by the membrane-proximal coil of the t-SNARE during zippering of SNAREpins

    Thomas J. Melia;Thomas Weber;James A. McNew;Lillian E. Fisher

  • Membrane-bound fatty acid desaturases are inserted co-translationally into the ER and contain different ER retrieval motifs at their carboxy termini.

    Andrew W. McCartney;John M. Dyer;Preetinder K. Dhanoa;Peter K. Kim

  • Content mixing and membrane integrity during membrane fusion driven by pairing of isolated v-SNAREs and t-SNAREs

    Walter Nickel;Thomas Weber;James A. McNew;Francesco Parlati

  • Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity

    Francesco Parlati;Oleg Varlamov;Keren Paz;Keren Paz;James A. McNew;James A. McNew

  • The Length of the Flexible SNAREpin Juxtamembrane Region Is a Critical Determinant of SNARE-Dependent Fusion

    James A McNew;Thomas Weber;Donald M Engelman;Thomas H Söllner

  • The sorting sequence of the peroxisomal integral membrane protein PMP47 is contained within a short hydrophilic loop.

    John M. Dyer;James A. McNew;Joel M. Goodman

  • The targeting and assembly of peroxisomal proteins: some old rules do not apply.

    James A. McNew;Joel M. Goodman

  • SNAREpins are functionally resistant to disruption by NSF and alphaSNAP.

    Thomas Weber;Francesco Parlati;James A. McNew;Robert J. Johnston

  • Membrane Fusion Induced by Neuronal SNAREs Transits through Hemifusion

    Xiaobing Lu;Fan Zhang;James A. McNew;Yeon-Kyun Shin

Frequent Co-Authors

Thomas H. Söllner
Thomas H. Söllner Heidelberg University
James E. Rothman
James E. Rothman Yale University
Joel M. Goodman
Joel M. Goodman The University of Texas Southwestern Medical Center
Benedikt Westermann
Benedikt Westermann University of Bayreuth
Yeon-Kyun Shin
Yeon-Kyun Shin Iowa State University
Burton F. Dickey
Burton F. Dickey The University of Texas MD Anderson Cancer Center
Walter Nickel
Walter Nickel Heidelberg University
Vesa M. Olkkonen
Vesa M. Olkkonen University of Helsinki
Vikram N. Vakharia
Vikram N. Vakharia University of Maryland, Baltimore County
Hugo J. Bellen
Hugo J. Bellen Baylor College of Medicine

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