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Vesa M. Olkkonen

Vesa M. Olkkonen

D-Index & Metrics

Biology and Biochemistry

D-Index
80
Citations
18352
World Ranking
4174
National Ranking
33

Overview

Vesa M. Olkkonen is affiliated with the University of Helsinki in Finland, contributing extensively to research in biochemistry, genetics, and molecular biology, as well as medicine. Their work spans 80 publications in these fields, focusing particularly on molecular biology, cell biology, physiology, cancer research, and surgery.

The core topics of Olkkonen's research include cellular transport and secretion, cholesterol and lipid metabolism, adipose tissue and metabolism, lipid membrane structure and behavior, endoplasmic reticulum stress and disease, calcium signaling and nucleotide metabolism, and lipid metabolism and biosynthesis.

Olkkonen has published in a variety of scientific journals, with frequent contributions to the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Atherosclerosis
  • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
  • The EMBO Journal
  • The Journal of Steroid Biochemistry and Molecular Biology

Their recent papers reflect a focus on cholesterol transport and lipid regulation mechanisms. Notable publications include:

  • "Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair," 2022, The EMBO Journal
  • "Coordination of inter-organelle communication and lipid fluxes by OSBP-related proteins," 2022, Progress in Lipid Research
  • "ORP2 couples LDL-cholesterol transport to FAK activation by endosomal cholesterol/PI(4,5)P 2 exchange," 2021, The EMBO Journal
  • "Compounds that modulate AMPK activity and hepatic steatosis impact the biosynthesis of microRNAs required to maintain lipid homeostasis in hepatocytes," 2020, EBioMedicine
  • "Cholesterol transport in the late endocytic pathway: Roles of ORP family proteins," 2021, The Journal of Steroid Biochemistry and Molecular Biology

Collaborations have been significant in their research activity, with frequent co-authors including J. Taskinen, You Zhou, P.A. Nidhina Haridas, Elina Ikonen, and Marcus Höring.

Best Publications

  • The Rab GTPase family

    Harald Stenmark;Vesa M Olkkonen

  • Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism

    Sabine D. Jordan;Markus Krüger;Diana M. Willmes;Nora Redemann

  • Activation of endosomal dynein motors by stepwise assembly of Rab7–RILP–p150Glued, ORP1L, and the receptor βlll spectrin

    Marie Johansson;Nuno Rocha;Wilbert Zwart;Ingrid Jordens

  • The impact of phospholipid transfer protein (PLTP) on HDL metabolism

    Jarkko Huuskonen;Vesa M. Olkkonen;Matti Jauhiainen;Christian Ehnholm

  • The oxysterol-binding protein homologue ORP1L interacts with Rab7 and alters functional properties of late endocytic compartments

    Marie Johansson;Markku Lehto;Kimmo Tanhuanpää;Timothy L. Cover

  • Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

    Sanna Heino;Sari Lusa;Pentti Somerharju;Christian Ehnholm

  • Role of Rab GTPases in membrane traffic.

    Vesa M. Olkkonen;Harald Alfred Stenmark

  • The OSBP-related protein family in humans

    Markku Lehto;Saara Laitinen;Giulia Chinetti;Marie Johansson

  • Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein.

    Jeroen R.P.M. Strating;Jeroen R.P.M. Strating;Lonneke van der Linden;Lonneke van der Linden;Lucian Albulescu;Lucian Albulescu;Joëlle Bigay

  • Human palmitoyl protein thioesterase: evidence for lysosomal targeting of the enzyme and disturbed cellular routing in infantile neuronal ceroid lipofuscinosis.

    E. Hellsten;J. Vesa;V. M. Olkkonen;A. Jalanko

  • Effect of short-term carbohydrate overfeeding and long-term weight loss on liver fat in overweight humans

    Ksenia Sevastianova;Alexandre Pereira Delgado e Santos;Anna Kotronen;Antti Hakkarainen

  • Biosynthesis and Intracellular Targeting of the CLN3 Protein Defective in Batten Disease

    Irma Järvelä;Markku Sainio;Terhi Rantamäki;Vesa M. Olkkonen

  • Co-operative regulation of endocytosis by three RAB5 isoforms

    Cecilia Bucci;Anne Lütcke;Olivia Steele-Mortimer;Vesa M. Olkkonen

  • Oxysterol-binding proteins: sterol and phosphoinositide sensors coordinating transport, signaling and metabolism.

    Vesa M. Olkkonen;Shiqian Li;Shiqian Li

  • Molecular cloning and subcellular localization of three GTP-binding proteins of the rab subfamily.

    Vesa M. Olkkonen;Paul Dupree;Iris Killisch;Anne Lütcke

  • Oxysterols and Their Cellular Effectors

    Vesa M. Olkkonen;Olivier Béaslas;Eija Nissilä

  • Genetic variation in PNPLA3 (adiponutrin) confers sensitivity to weight loss–induced decrease in liver fat in humans

    Ksenia Sevastianova;Anna Kotronen;Amalia Gastaldelli;Julia Perttilä

  • The mammalian oxysterol-binding protein-related proteins (ORPs) bind 25-hydroxycholesterol in an evolutionarily conserved pocket

    Monika Suchanek;Riikka Hynynen;Gerd Wohlfahrt;Markku Lehto

  • The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking

    Maria Kauppi;Anne Simonsen;Bjørn Bremnes;Amandio Vieira

  • Quantitation of the adsorption and penetration stages of bacteriophage phi 6 infection.

    Vesa M. Olkkonen;Dennis H. Bamford

Frequent Co-Authors

Christian Ehnholm
Christian Ehnholm Finnish Institute for Health and Welfare (THL)
Hannele Yki-Järvinen
Hannele Yki-Järvinen University of Helsinki
Elina Ikonen
Elina Ikonen University of Helsinki
Eero Lehtonen
Eero Lehtonen University of Helsinki
Kai Simons
Kai Simons Lipotype
Dennis H. Bamford
Dennis H. Bamford University of Helsinki
Pentti Somerharju
Pentti Somerharju University of Helsinki
Petri T. Kovanen
Petri T. Kovanen Wihuri Research Institute
Gerhard Liebisch
Gerhard Liebisch University of Regensburg
Marino Zerial
Marino Zerial Max Planck Society

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